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Database: UniProt
Entry: A0A068R776_9GAMM
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ID   A0A068R776_9GAMM        Unreviewed;       350 AA.
AC   A0A068R776;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   11-DEC-2019, entry version 31.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   Name=aroG {ECO:0000313|EMBL:CDG21995.1};
GN   ORFNames=XPG1_2340 {ECO:0000313|EMBL:CDG21995.1};
OS   Xenorhabdus poinarii G6.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=1354304 {ECO:0000313|EMBL:CDG21995.1, ECO:0000313|Proteomes:UP000032735};
RN   [1] {ECO:0000313|EMBL:CDG21995.1, ECO:0000313|Proteomes:UP000032735}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G6 {ECO:0000313|EMBL:CDG21995.1,
RC   ECO:0000313|Proteomes:UP000032735};
RA   Genoscope - CEA;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; FO704551; CDG21995.1; -; Genomic_DNA.
DR   RefSeq; WP_045959035.1; NZ_FO704551.1.
DR   EnsemblBacteria; CDG21995; CDG21995; XPG1_2340.
DR   KEGG; xpo:XPG1_2340; -.
DR   KO; K01626; -.
DR   OrthoDB; 853329at2; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000032735; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156,
KW   ECO:0000313|EMBL:CDG21995.1}.
FT   DOMAIN          38..338
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   350 AA;  38520 MW;  C366A1CCA468C07C CRC64;
     MNYQNDDIRI RKIAELLPPV ALLEKFPATE KSIVTVRQAR ESIHNILIGE DDRLLVVIGP
     CSIHDPQAAL EYASRLNTLR EELKADLEIV MRVYFEKPRT TIGWKGMIND PNMDCSFDIN
     QGLRTARNLL LDINNMGLPA AGEFLDMITP QYLADLMSWG AIGARTTESQ VHRELASGLS
     CPVGFKNGTD GTIKVAIDAI NSASSSHCFL SVTKWGHSAI VNTTGNRDCH IILRGGREPN
     YSARHVSEVK EGLVKAGLAP RVMIDFSHAN SAKQFKRQMD VGTDVCGQIA GGEKAIMGVM
     VESHLVEGNQ NLESDAPLVY GQSVTDACIG WEDTEILLRQ LSQAVKHRRS
//
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