ID A0A068SEA4_9FUNG Unreviewed; 1073 AA.
AC A0A068SEA4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Rho guanyl nucleotide exchange factor {ECO:0000313|EMBL:CDH60604.1};
GN ORFNames=LCOR_11386.1 {ECO:0000313|EMBL:CDH60604.1};
OS Lichtheimia corymbifera JMRC:FSU:9682.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Lichtheimiaceae; Lichtheimia.
OX NCBI_TaxID=1263082 {ECO:0000313|EMBL:CDH60604.1, ECO:0000313|Proteomes:UP000027586};
RN [1] {ECO:0000313|EMBL:CDH60604.1, ECO:0000313|Proteomes:UP000027586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMRC:FSU:9682 {ECO:0000313|Proteomes:UP000027586};
RA Schwartze V.U., Winter S., Shelest E., Marcet-Houben M., Horn F.,
RA Wehner S., Hoffmann K., Riege K., Sammeth M., Nowrousian M., Valiante V.,
RA Linde J., Jacobsen I.D., Marz M., Brakhage A.A., Gabaldon T., Bocker S.,
RA Voigt K.;
RT "Gene expansion shapes genome architecture in the human pathogen
RT Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient
RT terrestrial Mucorales (Mucoromycotina).";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDH60604.1}.
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DR EMBL; CBTN010000099; CDH60604.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068SEA4; -.
DR STRING; 1263082.A0A068SEA4; -.
DR VEuPathDB; FungiDB:LCOR_11386.1; -.
DR OrthoDB; 1367119at2759; -.
DR Proteomes; UP000027586; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000027586}.
FT DOMAIN 332..521
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 729..1030
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1073 AA; 122921 MW; 882744E15615599B CRC64;
MTNLRRQVFP VTPPPLSRCF NSTPSNGHHS SYSTCSDHAP TSLQHRMRNS KHNGSSSRSS
SSFAMPTPPC SRTDSQQQPS NLFLRGQPEP DTTTSSSSSS QPSNTYGINA YPGLLSYVAN
ELRRRIILND REKDGIEYKN TFTGQDGVDK ILAIICSKDR HLAVRVGRAL DSQHLFHDVA
YERHLVDSPS EIYQFNDRVL VPTNTRDSES PEIPRTPTPT ATDDPFYDET TATGLFGHGV
EEAATNYDFP SGVFVDLTRC YTPACMFDES PCYSYLCPKR LALTRQERDQ NSSNLERSSL
SASSLQYQRP RELWIDTVDP HVRQSISTTE WKRQEAIFEL IFTEDNFVRT MEYVNEMWIE
PLSHSEHIIP DYTRRHTFIQ NVFSNIMAIY QVHIQFLATL QDRQRERYIV EKIGDIVLEF
ADYFDLFVDY GASRYQARFI LEHERMTNMA FSNFVVATED HPASRRLQLN GYLSQPTTRL
GRYTLLLDEI LKYTPCDHPD QITIPKALAR IRSTLWRMNT RTGESKNRFD LQRINAHLRF
KNPADKVDLH LLDPERRIIK EDRLTKSPNP GSTEYQVILL DNYLLIARIK VQHGIPHYII
QRRPIPIIWL SVSTTEPKQP AAPVLPVLPG GIAASIGPHM AHHPIINHRP SAMYRRHSSL
KTYSNQHAYP ITFHHMGRRG SGSFTLFSPS APARKPWLDK IHELQSSMIR STAVFNSIPA
IKESEVYITD KANHMVTFND GRQYVLATSA GVFVGHNEPA SVSHKILAVE RVSQIEVLEG
AQKLLVLADR TLWEYALQVV NNSVGCDKRR KQIQSSVPFF HVGHCLGTTL VCIPKGTFSS
RIVVYEPQKL EDYSKKQKRA GRVPNPLDLP LKKFGEYHVP SEIWDIELSN TKMFVTTPRG
IIILSIRDPK SIMPMNLLNY NDPLLSFITI RERDQLRTIP KRINFFRTPD AQHIVCYDEF
AFYIDGQGNR ARPEFLIEWK GTPESFIFSY PYLLAFEPNF IEIRDIFTGD LVQVIRGQNI
KCLTSHHLYR SKPCFIFGTM TDPRNDCVQY IFRLDPIVVS FRKSAPPALL SSS
//
