ID A0A068U1R7_COFCA Unreviewed; 501 AA.
AC A0A068U1R7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN ORFNames=GSCOC_T00039884001 {ECO:0000313|EMBL:CDP02490.1};
OS Coffea canephora (Robusta coffee).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Gardenieae complex;
OC Bertiereae - Coffeeae clade; Coffeeae; Coffea.
OX NCBI_TaxID=49390 {ECO:0000313|EMBL:CDP02490.1, ECO:0000313|Proteomes:UP000295252};
RN [1] {ECO:0000313|Proteomes:UP000295252}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DH200-94 {ECO:0000313|Proteomes:UP000295252};
RX PubMed=25190796; DOI=10.1126/science.1255274;
RA Denoeud F., Carretero-Paulet L., Dereeper A., Droc G., Guyot R.,
RA Pietrella M., Zheng C., Alberti A., Anthony F., Aprea G., Aury J.M.,
RA Bento P., Bernard M., Bocs S., Campa C., Cenci A., Combes M.C.,
RA Crouzillat D., Da Silva C., Daddiego L., De Bellis F., Dussert S.,
RA Garsmeur O., Gayraud T., Guignon V., Jahn K., Jamilloux V., Joet T.,
RA Labadie K., Lan T., Leclercq J., Lepelley M., Leroy T., Li L.T.,
RA Librado P., Lopez L., Munoz A., Noel B., Pallavicini A., Perrotta G.,
RA Poncet V., Pot D., Priyono X., Rigoreau M., Rouard M., Rozas J.,
RA Tranchant-Dubreuil C., VanBuren R., Zhang Q., Andrade A.C., Argout X.,
RA Bertrand B., de Kochko A., Graziosi G., Henry R.J., Jayarama X., Ming R.,
RA Nagai C., Rounsley S., Sankoff D., Giuliano G., Albert V.A., Wincker P.,
RA Lashermes P.;
RT "The coffee genome provides insight into the convergent evolution of
RT caffeine biosynthesis.";
RL Science 345:1181-1184(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC ECO:0000256|RuleBase:RU004914}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004914}.
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DR EMBL; HG739092; CDP02490.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068U1R7; -.
DR EnsemblPlants; CDP02490; CDP02490; GSCOC_T00039884001.
DR Gramene; CDP02490; CDP02490; GSCOC_T00039884001.
DR InParanoid; A0A068U1R7; -.
DR OMA; CQAWQPS; -.
DR PhylomeDB; A0A068U1R7; -.
DR Proteomes; UP000295252; Chromosome 7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR PANTHER; PTHR11206:SF119; PROTEIN DETOXIFICATION; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004914};
KW Reference proteome {ECO:0000313|Proteomes:UP000295252};
KW Transmembrane {ECO:0000256|RuleBase:RU004914};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 128..145
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 165..186
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 193..214
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 220..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 266..285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 347..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
FT TRANSMEM 446..467
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004914"
SQ SEQUENCE 501 AA; 53575 MW; DFC65B38AF991896 CRC64;
MAVETSAPLL VDYINGLPKS NESFPDHEHH GSRPTLPEVA EEIKKLYTIA FPMIITGLLV
YGKSMISVLF MGRMGKDALA GGSLSSGIAN ITGYSIISGL AMGMEGISSQ ACGAKQWSVM
GQTLQRTIVI LLFASIPISL LWLNIQPILV FCGQDSNISS VAANHLAFCI PDLVFQSIIY
PLKIFLRTQN VTLPLILSAV FSLALHAPVN YLLIHKLGLG IRGVAAASSI TDFATLATLV
LYIIFSGVYK RSWPGWSLQC FNQWKPILSL ALPSCVSVCL EWWWYELMIL LSGLLSNAAE
VVATMGILLQ ATSLVYIFPS SLGLAVSTRV GNELGANHPS KARISCLVAL ACAVFTSIAA
MSFVTICRNA WGRAFTQDKA ILSLTALSMP VVGLCELGNC PQTAGCGVLK GCARPVLGAT
INLGSFYGVG LPLAIITGFG LGKGLLGLWL GLLVAQAVCS VLMLFVLRGT DWMDQANRAS
ELIGITVDPD RESRGEIRNM E
//
