ID A0A068XU84_ECHMU Unreviewed; 630 AA.
AC A0A068XU84;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Guanine nucleotide binding protein subunit {ECO:0000313|EMBL:CDS35866.1};
GN ORFNames=EmuJ_001182200 {ECO:0000313|EMBL:CDS35866.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS35866.1};
RN [1] {ECO:0000313|EMBL:CDS35866.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS35866.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The
CC alpha chain contains the guanine nucleotide binding site.
CC {ECO:0000256|ARBA:ARBA00011356}.
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; LN902841; CDS35866.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068XU84; -.
DR STRING; 6211.A0A068XU84; -.
DR eggNOG; KOG0082; Eukaryota.
DR OMA; WLENAFK; -.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF302; GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-8 SUBUNIT-RELATED; 1.
DR Pfam; PF00503; G-alpha; 2.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 291..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 71202 MW; 1D068695D4372161 CRC64;
MQTDSPSMFK KSFIFQRNLR EGLVKMMRCR KSSLRSFLID QELLEDQELR RREIRLLLLG
NRGSGRSTMV KQLRIHYGDS FPTPVRKFLI PFITANLADA VVRVVKIMED MGDGIADPYV
QELTIQLIRN RPSEGYTAAI SSDFYNKSLP MGTTARNSSV ETKAIHSIIE DERISQNTPR
MSALLNTSGQ TNLQPGIPPT STTDTPLHIK LSKSLTVKEI QSLLGSLHPE VDWAEVIQTE
VFNKAPVGAN QKEVLAAWLE NAFKTGKLHP AKVTAALQER VRNPHIRKLP ANIAAQLPPP
NETPPTPPST SAPDLDSNIL TDTDDWSSNT SFQSENKSLS EDDAGLHMDA PTEEKLAFED
GEVKPRPSLT NVLVDKKESL VQNFQDFNVV SLSGRMLKLI IDRPEFQAVL AKGTEIHLEL
STSQIYFINN VDRFIQSDYV PTLRDILLVQ MPCNAVRESL LQIGSTSLRL VNVGDQRGDR
RKWISLFETV HAVLFFASLI DFLERSQLPE FKTKLDESLE YFWFIMESLP LSRKDSVLFL
TKKDILPVLQ SNEKITVASN YPELQELKDP ETCIATQRNL YLSKHKERGQ KTGRVFIHAV
CLLDIDEMKA KSRSALKGVL DSNFRRHAMF
//
