ID A0A068XZH4_ECHMU Unreviewed; 3149 AA.
AC A0A068XZH4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Chromo domain {ECO:0000313|EMBL:CDS37840.1};
GN ORFNames=EmuJ_000512800 {ECO:0000313|EMBL:CDS37840.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS37840.1};
RN [1] {ECO:0000313|EMBL:CDS37840.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS37840.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN902843; CDS37840.1; -; Genomic_DNA.
DR STRING; 6211.A0A068XZH4; -.
DR eggNOG; KOG0384; Eukaryota.
DR OMA; YYRAIME; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd17995; DEXHc_CHD6_7_8_9; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.40.5.120; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR006576; BRK_domain.
DR InterPro; IPR037259; BRK_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF11; KISMET, ISOFORM C; 1.
DR Pfam; PF07533; BRK; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00592; BRK; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF160481; BRK domain-like; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1091..1283
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1429..1579
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 32..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 614..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 784..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 936..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2098..2123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2425..2446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2485..2537
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2598..2623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2665..2778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2933..2985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3022..3056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3072..3149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..668
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..733
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..751
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 795..838
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2098..2112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2430..2446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2486..2537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2603..2623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2933..2959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2969..2985
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3149 AA; 344855 MW; 7F1B1E06073351B8 CRC64;
MDSHSYSGFN TSGSSFLQEL TVEDPTKDVY AGSQVPQQRP YQAVQDPNSG HYSTPSDVSP
GSYYNGQYNV DPYYFNHPVY PQRGKYPENY VTVPISSQPS ANSQVAPRSA SGQSSMSASW
AESQQPPQYQ SDHYTPQSTF HSSGGNSRMS VTNYPSGHMA PVGGSSTHQS YQNSAINPYQ
VTPGPYCHSE MPPNAYTGLS PPPQQQQPPT HSLSINGEPM NPYAQQSRIS PNTPRQQLPK
MVAKRPPKPR GSGPVVKSPY SQNPMHEPAA LERFVNTQCP PNVISVGPTN ELSSNSLSLP
PQPQQPPLPP TSINSLQVCL SMELPPHVSS PVESRCQTVN KPKSVSPALV EREEGQAVSQ
ALNTSPLRVK SPRLRIPPFQ PCTSTSSLPS SHILPPLTSQ SASSVVSSPQ AAAFSPRLEQ
VPEGSPQPPS LKSPLPLRSP PASSSNDNLP PILPKEPSEV REDLMEEIKP TGLCSAEQPV
PSENVIPGLS KSNLEADRSP QKRLRGRKRK MEQSEGKGEA DPSKLPPSIT EKKRPFKATG
STGRRRGSPL PSSGAKRSRR KTVPSKAVVN YDLDANKRGI EAEDLDKSSF SEVKASMILE
GDDDEDTMAA SVALTEVDEE SVTATTTTTT EETTEVFLKR PRPPPRLRAS RPKKKKKKPL
KSLMKKKRRG AYHYGDESDG SDSDDDGGGC SSRSALHPVL INSQLRDENS LDSSARRSGR
RGTDRKKYTI DSVDFGLSDD GDGEGGDSAD ASDNETVEGS GRRSGADFVV VKVVEKILGH
RMSTRPVKKL QKGQRCVSPK RDHPNPDMRE MNPFVKKDDG KVKEAEHRMD RDQQHQEKAE
VEEEEEEEEQ VEEFYLKYKG FSYMHCEWKA LDEIADPRIA TKLKKFLAKN GTEPLPPPSA
DDDDGTTVLF NPDYVEVDRV LDIRIYDRVS GDIVTDDVLN PDGTIKRPQG QQRSRKKRGR
PPRSRTQEEG LEDEVATTNA DTPDTAESET QDEAPTLDDE QPATVTYYLV KWRSLPYEDA
TWELAEDVDP AKVREYMRIR NPPKNPPVIR DSNHKIIRPD PSVWRPITED GVYRNDNRLR
EYQVEGVNWL SFCWYNKRNC ILADEMGLGK TVQSIAFLLE VIKAGVAGPF LIIVPLSTVG
NWQREFENWS DLNTIVYHGS AVSRSMIQEY ELFYHRKKAA GGSGAALSGA SNNPFSSQYR
HDVYKFNALI TTFEVLMSDI EFFGKMHWAV AIIDEAHRLK NKKCKLGEGL RYLDLDHRVL
LTGTPLQNNV EELFGLLNFL EPERFACAST FLAEFGELKT EQQVEDLKTL LKPMMLRRLK
EDVEKSLAPK EETIIEVELT NLQKKYYRAI MERNFTFLCK GTTASNMPNL MNVMMELRKC
CNHPFLIKGA EEAILAEQRV LAEADPSKPY NEEQQMFNVM LNASGKLVLI HKLLPKLKAG
GHKVLVFSQM IRVLDILEDY LVYQGFSFER IDGRIHGLLR QEAIDRFCND PDKFVFLLCT
KAGGLGINLT AADVVIIYDS DWNPQNDLQA QARCHRIGQQ KMVKVYRLIT RNTYEREMFD
RASLKLGLDK AVLQSTGAHA RQAQLSKKEV EELLKKGAYG ALMDDDKAGD DFCEEDIDQI
LQSRSHVVQL EQGEKNSTFS KATFSISDNR NDIALDDPDF WQKWAKKAGV EEVGLEFEDL
IMTTPRQRRQ THRYTAELNE QQSSSSLTHS QCASRLPNGN NGGGSNAEST DGENSSGESS
CADDDGGDSR ASGTTIGNIV PSSKPKHKKS KKSRRNEEGI GESIDRVDLF RVEKCLFTWS
WGRWAHAIDC FPFKRVISEM EMQRIARCIL GYALKVTPAL TSGGDARVRA VVMEMISSVD
VNGLRTIADV VQSLKASNSE VSLRGPGGIS SITSGCGVVV RRGRRAGLRI GGLGTDSPND
PSTPTTPIML NFDMDPASTV DTPKQEDHTQ DFSKREEDLD QVDFGITSDS FKRHLVRAGG
RLLARVYTLY FLHTEIVGLE HADGLCDGSL DHSVFTQLAE SLPPLKALDA DVPADWWDSC
CDKCLLLGVF KHGWEKYFAI RDDPAFCFYR RVYGSNAPTI PIPSTIGTLK GVAGIKIKSE
EQEEGGDSEP TMRPEEMEEE DDDEKILTIA TDDITAVSPR PKSEVTKAEV GEVETETQLP
PPLLLFPAVV DLNSRMRKLI AYFQRVRAQV ELESVHNLRS ECIPSVTTQP YLEQRIIKWS
RREEADFYRV VSSFGVEQVL RSPPHSPTSS RRPGGGRLFM GYNWTNFKVL ANLSKKSDQA
ITEYYNSFFT MCHRVCNEPL PEGMSAPVCS LPTTTTYGSC PADDVIPVAP ISEERATRTL
SRIKLLNRIR NNILTHEHLE ERLTLCQRSS DLPEWWVPGQ HDRELLQAVA RHGLARTDLN
ILPDKKFSFS RVSALVRRQL LKNPSALHGV TPPTAGTSTD TTLGGPLSVS EVEARASLAA
AASVAARAVA AELEAKIDAA NVPRTEGSLS FGTTRKESEN QGNPVEDQSE NGAFEGRTNT
ATSSEPNPDS PSFDTKPINN EHFRWSLQFA TSLAVGWPKD RAIHNRLEMV CQCIETGHWP
LPRRYILNNV EELGRYHLTD STGGGSRDAS PAPPSSPDIS TQKKALTSAE VATLAALSAA
GYTSIDQVLA FQAAVAANAA AASAGGHQSD IGAGTQAAPT AVSSRGGRGG GRGSRGGRGR
GRGSRGGGGA GAYSREDFAS AASLAAVNKS TESPLPTRGR GSRGGQMLPP RGSPGFTRGR
KRKFETTDTK TSLPPPDSSA WEVNVPLISL VNGNLIHGEK APKRRHLEAW LEAHPDYMPY
SVEPEDQVIF NRVAKARGQD TLAMEALAYR HYLSSVLSKV ASYTASSSSQ RPTASTSTAS
ASELMEHQQK QLLAFVAASA YSGNPAYASL IASALGYSQA AAAAVAAATS SAPSIQQKSS
DMEKPSTSSS STASDPVTID DQAKRSGGAE ASSIPSASTS TTATSHLTPE NFQSVLTAYQ
QAASFVAAAY MYNPSLYGQH FSSGSSSMNA TATSGSTPAS SSSATATGSS DAFQRQQRSN
LLSSVLGSTA LNSQPTTEKA IEVPASSPQP PPQLTLRQET EGEERPAVDE EEVIGGAGSG
SKPVIVATGE GCGSSSAGDG DVLDLSKPE
//
