ID A0A068XZI2_ECHMU Unreviewed; 629 AA.
AC A0A068XZI2;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Set1:ash2 histone methyltransferase complex {ECO:0000313|EMBL:CDS37632.1};
GN ORFNames=EmuJ_000489600 {ECO:0000313|EMBL:CDS37632.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS37632.1};
RN [1] {ECO:0000313|EMBL:CDS37632.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS37632.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; LN902843; CDS37632.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068XZI2; -.
DR STRING; 6211.A0A068XZI2; -.
DR eggNOG; KOG2626; Eukaryota.
DR OMA; CATCSRW; -.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd12872; SPRY_Ash2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR InterPro; IPR037353; ASH2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR10598; SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR PANTHER; PTHR10598:SF0; SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR Pfam; PF00622; SPRY; 2.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:CDS37632.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000313|EMBL:CDS37632.1}.
FT DOMAIN 314..505
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 179..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 629 AA; 69423 MW; E5650090E514B50E CRC64;
MDTSESSLEA ANENESKMKE LMSKTIQIEV APDQQCYCAA FVIGGFITNA LVSTLAYHFM
CKKCNNSSEE VFSKKQANFA SMCQTTLANL MCIRNGRIYF SEEKELIPYL EQNWELLTSQ
PRRTNNSWHT NIHKTLVSNE LFNVVDLDPQ HAVCLSCQDV STIGPSYERF RALTSQLKTS
VSKRNAHPST GQLTDLAGGG DSSSTAGDGS EGGMGKSLRK GGQVCGSGAS LSASGSGGCV
VGGNVRSTRR STAAAVASAG LSAGSYGIGC HEDNKTKISE FGIPLDHPVN TENYRYALVE
VDPHAKGRKQ WDECENTAGK PIPGYFYRVC HYPKVVLSLH DRAQQMKVQD SQTSVTGEKG
YSMTRATHSV HTGTWYYEAT ITDHPEGSAT RIGWSQLMGN LQAPCGYDKF SYSWRSRLGT
VFHNSRGKHY AESGYTKGDV IGCLIHLPKV DSADMIPSTA GVHALPSGPI KHNKPGLKSD
FSRVKPLIEA PLINYLPETY KDRPLIKFRN YYYFEEKGDP QALEKQLQPL PRSKIVFYRN
GECLGVAFRD IYAGAYYPAI SIYKSATVSV NFGPDFKYPP QESENWLPMS ARRESAEIEQ
TMADMLYLLA NDRLIEHLMK QCNSQAAAK
//
