ID A0A068Y0R3_ECHMU Unreviewed; 788 AA.
AC A0A068Y0R3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Metastasis associated protein MTA1 {ECO:0000313|EMBL:CDS36682.1};
GN ORFNames=EmuJ_000381900 {ECO:0000313|EMBL:CDS36682.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS36682.1};
RN [1] {ECO:0000313|EMBL:CDS36682.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS36682.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902847; CDS36682.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y0R3; -.
DR STRING; 6211.A0A068Y0R3; -.
DR eggNOG; KOG3554; Eukaryota.
DR OMA; HEWLILT; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd04709; BAH_MTA; 1.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 4.10.1240.50; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR040138; MIER/MTA.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000679; Znf_GATA.
DR PANTHER; PTHR10865:SF29; METASTASIS ASSOCIATED 1-LIKE, ISOFORM D; 1.
DR PANTHER; PTHR10865; METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF01448; ELM2; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00355; ZnF_C2H2; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 56..198
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 199..310
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 317..369
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 519..545
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 453..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..498
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 88338 MW; 748F9251FD43A127 CRC64;
MPRSRGVNVG FRNAHPSGDA AHAHELVKLG LTRYRVIWQK PRLLNSSRLW KMSSSNKYRV
GDFVYFETNA TAPYQIRRLD ELVMTPNGVE AKVTCYFRRR DISNTLIQQA EKYYFQETDD
FSGETTPPLS DLQRHQVKHR ELFHSRTIES LPATHIRGKC TVTLYNEVEP LTSYVEREDA
FYYRLIYDPN TKRLQEDRGS MRIGSDFQCD IQPLLAKGEG DPRFKQNLEE ILWNPLNSPS
LSEMDTFISA VKAVGLYGRA CDPASSLQNP LLINAAAAAS RDVTLQFAHD ILFRAGFDVQ
KAMTHLLPNG HPVVCKDELE MWTAHESSMF EEALGKQVKD FTHILTDSLP WKSSKSIVEM
YYFWKTTDRY TRHRKNKMAT KEQKLKQVYI PDYSKPNSSV LYNRTDVNDR GCECCYVETS
PQWYAWGPPN LMCRLCSGCW TYWKKYGGLK NPDKRGAPVN SRPSPEQRVQ DRLEARKSAA
AAAAASTNSS SSIEGSGVSH QKAPPLHPYS DISLAPTVYR CNQPDCVKEF RSKENFAIHL
AQVHSVTLIS DGSSNIPVAL AAAAGVFQHG AGTQGILTPP SIRIVRTLCP LLLRPAILAR
RPTKLANSTA QQRSPSEPII PTDDLMARLG NLAKSRIPAL RDPQAVLKRK LPVRSLKSVV
KKLLLRLGRN DDSAIISAPF KRSFDSASIA QNGDAANGVE QPAEKRPRIE AVAQNCSSTN
GRVGFFHFSP PLSPPSTSRS LCTCSLYMFV PTLVLSLLPS SLFGSLGERR LQLSTNWYSS
VLSPHPRD
//
