ID A0A068Y1D1_ECHMU Unreviewed; 878 AA.
AC A0A068Y1D1;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Pdz domain containing protein {ECO:0000313|EMBL:CUT98878.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CUT98878.1};
RN [1] {ECO:0000313|EMBL:CUT98878.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CUT98878.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the CNKSR family.
CC {ECO:0000256|ARBA:ARBA00009498}.
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DR EMBL; LN902845; CUT98878.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y1D1; -.
DR STRING; 6211.A0A068Y1D1; -.
DR eggNOG; KOG1738; Eukaryota.
DR OMA; HTEMSEP; -.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF42; CONNECTOR ENHANCER OF KSR PROTEIN CNK; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
FT DOMAIN 3..68
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 76..169
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT DOMAIN 209..292
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 505..606
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 388..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 457..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 818..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..503
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 878 AA; 97645 MW; 4AC605C86C5C7D54 CRC64;
MTWSNAQLVS WAEGVGPFFQ PYLAALRASN VRGQWLSCLT DFDLQSLGVT KIGDLRCIQT
SVSRLIEDYA GLEAENMQSL LFSVVCVTGQ LSALLKRARL QEALTEAAGE VEHQLVKCLL
RLGLVVRKAA SWLERGPFSL ISRLAALRGA MLQHTVDLNT VLQSALKNSS LLTYVNAMLE
LTRGLRDQLE VVIHDCDDSL LLTPCTVERV SLRKGERERY GFTFFTNDCN VHIIQSLDSD
LQAPAFSCGR IARDDEIIEV NHQLVLEWEH SAVARLIQQS NRRLDLLVRK RPAHCTDYFS
ANSRRQRMQL MARVLRPFIA EPQHSRRVFF DFLRNRAPKR RTQLLSNSAN TPATSTATIT
ANISHEEKEE EVETAQAAVS VKTLANAELE STTTENRLKA PISLSRSHSR PRQERYSQAL
QPPLLLSASA CDHTEMSEPP PSPLTNESDF RTQIRSPFEI ATTPPHSNKR RPVTLGSLDD
FSAESGAAAS ASSTPPSSMN LTRPKNSCQG WLWLKKRTST SFGNRYIKRW CVFKHNTLYY
YRNQEEENAE GLILLHGFTI SPVATDGGRS GRYPFRVYNE WTRFVFAADS EVARTRWMNM
LGLAAIGQSA CLWTSPIGGF YPGYLPAPLG TATEVEKEVI AVNPRLLEPP RPHTSGGENL
SRRQPVTIHR CSSSLNFPSS SGLQQTPLDT SPLSSYHSKS GPHHHHKQQP HRHFLSVSAS
CLVGDTTDDE AENTKKRSEN VDEEAETSTS QSNQSPCRLT RRAAMIRRRR VRRLTEGSIS
PSVFLTSPPI TIRPHHSSGW MSLSSETVVM ASGFLGQQQP QNQDQQRLHS MGTSSGGDEG
EGGSEGGSLL FLQNPNLLSP TCSLSSRFSE SPEQVPSS
//
