ID A0A068Y2B6_ECHMU Unreviewed; 1223 AA.
AC A0A068Y2B6;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 22-FEB-2023, entry version 37.
DE SubName: Full=SPRY domain containing protein {ECO:0000313|EMBL:CUT99031.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CUT99031.1};
RN [1] {ECO:0000313|EMBL:CUT99031.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CUT99031.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN902845; CUT99031.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y2B6; -.
DR STRING; 6211.A0A068Y2B6; -.
DR eggNOG; KOG0349; Eukaryota.
DR eggNOG; KOG3527; Eukaryota.
DR OMA; WQGCRAN; -.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd01765; FERM_F0_F1; 1.
DR CDD; cd12873; SPRY_DDX1; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF21; PROTEIN 4.1 HOMOLOG; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00622; SPRY; 2.
DR PRINTS; PR00935; BAND41.
DR SMART; SM00295; B41; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00449; SPRY; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50188; B302_SPRY; 2.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
FT DOMAIN 146..429
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 544..742
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 758..958
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1185..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1223 AA; 133808 MW; AEC8C1FF419BCBEF CRC64;
MALPPSIVSS LTPEDSFDYP GSSVLGSPGR RSVDGDTTAG SINLAHLEQN AGRSGAATLQ
QYNSTIEVPD SVPKREYYTS LRRFGTVGRQ GSISGGSMLG GGGGTNTLGP VTAVGSPYPS
ATMGRIATFG RSNTSVSNFK PSGKSVDCAV IMLDGLQQMF SIDKAAYGQQ LFDAVCANLD
LLETDFFGIK YLAPDNTMCW LKMDKKVAKQ VGKNWLFEFQ VKFFPYDIDS IVEDLTRYFL
CLQVRQNLLS GQLPCSFFSY VILGSYVVQS DAGDFDPKRH QGIAYIRDHP FAPSHLQSTE
MLYRIAETHR LHHGQSPEMA DRNFLNNSKK LALYGVHMHK VLSSSGVEHG LGVYYGGLLL
YLSRIRLQRF SWPRIIKLSY RKRHFIMIVR SLDEDQSERT YAFRCATPQR AKRLWTLCVE
HHNFFRLRSY EHSRKPSVLP GFSSRKFTYN QPGMANSLGD LTGSEAVPSH RPQPAIRRMQ
PQRKRISSTD QTWFTLPHGV NPSTYAADAF QNQYVPQIAS DASLGGDGVG YSPEHWGGGE
AACEMPAGAA YRRGLGGSNH LGDYQPRPIF KPEPWRISTA DRSRCLGIDD RGLDIASQRD
SGWQGCRANK GVKAPGCYYF EATVLEDGPV GVGWATNEAG LTSLGCDDHA FVLGNIEGGQ
GAATLTFKGK QVDVSNGRIA VGKGTVIGCC LDLDRGIATW NCNGNECPQV LRIPENLINE
PFFPAASMKD SRLLLNFGGS TSPPLRFIPT SSGGGSGGFV PLADVVEDAQ VTNENCGWRL
NPYDATAGVE VRPDGMAVQA HWGSGWQGCR ANRGVRGEGR FYYEARVIES NGLARIGWTT
EDGSLLVGTD SFGFGYGSDC EGFGLSGQQG KRMHNNEIDN YGESYGEDDV IGCFLDLTQR
TVRWAKNGHP FGDAYRLPDD FATAFAANDS SVARRVAFFP TVALNNSTVE LNFGDSQFSY
FPGDLNGPKE PDWTPLSYIA PENLQVTSRP GPMYKRRGWS YLEPQVGISE GKSVMKPSVD
RREDDLSPTA HVAPRLHLAG AVPVMPGLTS VLSPPPKRVA PKTPSMGNGY HTNGDHTELA
DAIDGIQLSP SRRQHPIPLD SGVGETVTVQ RSEPKIESEL IEDENGKIIK RTTKRTQVVT
TKTYSERFIQ PESFIAIPNE NDHELDQAIL KVTQLDPRVF VRTTNLHHSA PQVPGKRSTS
NGRSAHISST NGDSAISNST LTH
//
