ID A0A068Y473_ECHMU Unreviewed; 622 AA.
AC A0A068Y473;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Tbc tre 2:bub2:cdc16 domain family member {ECO:0000313|EMBL:CDS37937.1};
GN ORFNames=EmuJ_000523000 {ECO:0000313|EMBL:CDS37937.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS37937.1};
RN [1] {ECO:0000313|EMBL:CDS37937.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS37937.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
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DR EMBL; LN902847; CDS37937.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y473; -.
DR STRING; 6211.A0A068Y473; -.
DR eggNOG; KOG2058; Eukaryota.
DR OMA; NEPMFEL; -.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 1.
PE 4: Predicted;
FT DOMAIN 45..79
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|Pfam:PF00566"
FT REGION 464..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 622 AA; 69340 MW; 31118EA46B198246 CRC64;
MPRAYEFGTL IPNHTPIKQY IQWTLARYFL SSVEFFQQSN QLSRCETLLR IWDVFLLEGE
KVLFRVAIAL LLQQQDVLLR QSDTLAFWKS MKIAVSLVYD YEELLSIAFN GFKMVKRKEL
KSRREAKMRE LEKRHQLSCA LDELKAKGQV NNISGRDAPQ SPRTFFASAL DESSPCFIMS
CAENDSYVLK LGNTDENVYY AIEGQFDAPI MCAAWIKDSH ILLGSAKGYL YAYDIGPKQK
TWEIKMSGGI TAIAIDRQRN GTKHAFVGTA NGILSLIVDL AGETAPRDLY SQTLGFIAVS
FISIIDTQLW CACGCVLEVF DVTTFDHIRK ITVSENPLDS ICSLAPCSNG VWISLVGKTS
LKLLSTSTFE PTCYCDISRY LPSRGSNALL ESENPDRVTA VLANDSYLFI GTGSGIVCIY
KTLKWKNSTL PHVKKLQTST RHSINISECK TSPKILSRSL HRLTSKGEGD SDIDEVPCNP
APEIRSPSSG SQDAINFSSC TDTTVEDEKP TLLKGAVPRM RGPLVNSLNL LFSIKSQITE
SPIRAFLQVT NKQGNCIVSI SQRSNEDDAV LKWVQKNKGG CPWTNEPMFE LCLKDSTPIL
PGYLKSATLR KIPSVDSTFH LQ
//
