ID A0A068Y7B8_ECHMU Unreviewed; 452 AA.
AC A0A068Y7B8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Sh3 domain binding glutamic acid rich {ECO:0000313|EMBL:CUT99519.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CUT99519.1};
RN [1] {ECO:0000313|EMBL:CUT99519.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CUT99519.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SH3BGR family.
CC {ECO:0000256|ARBA:ARBA00007764}.
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DR EMBL; LN902845; CUT99519.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y7B8; -.
DR eggNOG; ENOG502QSSK; Eukaryota.
DR OMA; FANQDDD; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR006993; Glut_rich_SH3-bd.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12232:SF0; GLUTAREDOXIN DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12232; SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN; 1.
DR Pfam; PF04908; SH3BGR; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 380..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 119..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..151
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..277
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 50584 MW; 382F64663BD7FB50 CRC64;
MLSNILTARR IDFEQIDLTD PKNVAKKQAL IDELKGKSLS FVPPVIYYED EYLGNYDDFF
ESLEMERVDS FLRLPGAKSK TFDDIVSGTE VAGSPIACLF VSHLQAGLTK QALKVGGAVK
KKKQKKEGAG KEADEGESED LSEESESGDE KNEEEKSENN NEGASGSKSK KREIEEGAIE
ARSEKLDESA PKAELRLTSS SEEEGDESEE EKSGKETSTK AVEEAEEKAT KSKNDLASET
SSEEESSEEE EESKGEIEMK QAPEKEESEK SAESSSETSE ESETAEEEAP IPKTVAESKV
VKKEEESSST ESESEEEDDE KNTKSEKTPT IEAKKIESKK ETSESSFEEE TSSSEEDLFD
ISAVFIFLIC FPPKILVHSA FFHALLEVYD VIRCLFFLFR CLLTARKYLK DKHACLMNRY
LTALLFCFVY TPFLVRSFAH VIRVINLSSV RR
//
