ID A0A068Y7L2_ECHMU Unreviewed; 1628 AA.
AC A0A068Y7L2;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Dedicator of cytokinesis protein {ECO:0000313|EMBL:CDS38301.1};
GN ORFNames=EmuJ_000568900 {ECO:0000313|EMBL:CDS38301.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS38301.1};
RN [1] {ECO:0000313|EMBL:CDS38301.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS38301.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; LN902841; CDS38301.1; -; Genomic_DNA.
DR STRING; 6211.A0A068Y7L2; -.
DR eggNOG; KOG1997; Eukaryota.
DR OMA; YLMKSHE; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 1..160
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1158..1621
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 676..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1628 AA; 184143 MW; D45814ECEADB1D95 CRC64;
MLKGVSKNIE IVMQLWCSNA SGRHTIPAFH NLGAQNVLKT EARTRIILKN RSPEFTDEIK
VILPKELNSN HYLLFTFVHV DLSPSRDTSH SVLGYSWLPI LISGRIFSGE VKLYLTHDHP
TPQMAQSIPR HVEALAKDNM EAGKTHFLNK TSFHLRVVPL SSLYQDDDFV ASVIRECNFA
NFTETSESLS KQDLFLAQSG SDSLSSPPTL LLHLQKAKLN QLVLHLVPIM DGLLQTLGAC
LVQNNVKASQ NLLTLLAFYV HRISKGLSDW EEQFTGRNRF ICAYLSGIGR CSIEHVLPYL
LSGYPMMGLA WIDDVFGYLH RSNENLTKKL HGELLQCLIG QIATNTPFSR NFYEETLWFF
LELLVRTLIV ECKISDESAS QLFMENLDLL TREVTKSITN RIMQDDKEET FDSACLLNRA
FAFFLQDLLI CINATHVFRF TSAYMQAINS FIEELLVPSS WNSEDEEAAS SRGKKVRNLQ
LLKLEMLQIL TAAPDYLALS LPDQSLLPDT VHSINQVAYF TTFEQGDEIL TDPTYQRLHF
LPAMLLGEIR TCLLHSEPAL QENALTTLWY LMKSHESQGC TCRAGRESSN LWDVAALYIP
LLDIACDNAS AMYASWVGSL KKQERVLREV AKVSVLLNAQ RSSNDGTSKR SGWILSSMTA
KERIRWMGRR ISLTPDRRGS VEHRSSSAPS LPSQHEYTTF PSPSKTWIHA VLSSAPFSLP
SETTHVFSDC VTRLLLLETL WILQYTHQQV ILQWLVTRGV AKAQNLVELL ILALNYFEYL
GGNEFSTEST DEDSKVVQKL GESPILQLKR LDDLGCQTTD TLPVACREKT KLLYLFVTSV
VCKTLDLLIN TFDHPLSASD VTGEESDNLI ISSRLICIIA RAYIFGLSMH NCSKTFQLLC
CGMSELISKF PQYFLDEASV THFVLCRVLL PHCASPLKKI RKIANAATFH LLQQCHRVCD
HLYPVNGQMA LALHSLLAPN DLTLGTSSYP SWFARRLEVV TECFSYLTEA STNLYWHHLL
SHLIYDRRIH GGQEGDPLFP TLAPPHIHFL LARAHLPACF RALKEYAKAD TREGDDLGRN
RGGGGVSFNG LRFAMAFANT QAPDAGFQAQ LNASVDILHD IFTRLLHFND LQRRYTGSQI
VEKDDQISVV ELLVDLASVC RLLPELRQYW LLRLAEVHLF FKQPAEAAQA LLHTLAIDVE
QMVSRKSSPL FTVLSEGVDS MARQLGSPNL LEESALELAV GLPASTPLPI TAERSLQKTS
ANVFVKRFYE LIERITKCFH AADQSEQIPS LCYWILPILY STGEQECLRQ VYELIRTSHS
AIYEPARKNR LFNTYFRVGF YGPLFGDQNG KEFIYKEAPL TKLAEITARL QEFYSHQLGG
KPVEIIKSSS RVFAADLDEA IAYLQITYVE PHFEEFELRK RRLESERNYG IKRFVMVTPF
TQAGFAHGSI SEQFKRKVIL TTSRCFPCLN LRLPVIGHEE LVLSPIEVAI EDVAKRNQQL
ALAIHTDPPD AKFLQMVLQG CVSTTVNQGP LEVAVAFLNK RGSPSSSVSQ EDPVITVSES
DDEQQNELRL CLKEFLRKSQ EAVQMNRQLI GQDQEEYQRE LERNFVQIKL QMEPFLKPPI
SFRDLITV
//
