ID A0A068Y852_ECHMU Unreviewed; 533 AA.
AC A0A068Y852;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Translation initiation factor eIF2B subunit delta {ECO:0000256|ARBA:ARBA00044147};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit delta {ECO:0000256|ARBA:ARBA00044356};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CUT98833.1};
RN [1] {ECO:0000313|EMBL:CUT98833.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CUT98833.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR EMBL; LN902845; CUT98833.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068Y852; -.
DR STRING; 6211.A0A068Y852; -.
DR eggNOG; KOG1467; Eukaryota.
DR OMA; YAEGIIC; -.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR InterPro; IPR000649; IF-2B-related.
DR InterPro; IPR042529; IF_2B-like_C.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR PANTHER; PTHR10233; TRANSLATION INITIATION FACTOR EIF-2B; 1.
DR PANTHER; PTHR10233:SF14; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA; 1.
DR Pfam; PF01008; IF-2B; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:CUT98833.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}.
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 533 AA; 59041 MW; E7185EA559D70ADA CRC64;
MQVSSDPPKL SKSKAELRRE RRELQEAQRA AKMAAKGAKQ TSSVAALKRT PELQSDANVG
PLSDRTRQQK QKQLQQEEFV LGSQPSISSQ PTTPNKSQAA ANAPAASGGQ QALGVMRMDD
PAHFKKSVRQ LHKKKLQPRP QEPVRVNLFC HLSQPDKRVN VLGQHKLGIT SSIHPFFLRL
GLELDEGRVT GSNRRCLEFL RATAALILNF NWEETPGIGG SLARAFHTYF DRHVTFLDQC
RPLPVTVRSA VQYIKIMLHR LDEVNSPEEM KSQLLDAVGN FMDERVHLAD RAIANLVAES
VPPGGVVCVF GESTVVAKAL QVTWETRHQN FTVLVVDCRP RCEGRRMFLR LRKIGIPCEI
VHIAALPMVA PKVSLTLLGA HSLLSNGYVI ATMGTAHVAN IVASVAHTPV MVCAETYKFW
ERAQSDAFEF NELGDPDEIW RGPRGTAADW RVPKDPDFVV DKGTHSEAWR ELSQRADGLK
NLRLLNLVYD VIPPELVSAV ITELGILPTT SIPVVLRVKQ ASIEATNSFI STL
//
