ID A0A068YA34_ECHMU Unreviewed; 3057 AA.
AC A0A068YA34;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Nipped-B protein {ECO:0000256|RuleBase:RU364107};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CUT99425.1};
RN [1] {ECO:0000313|EMBL:CUT99425.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CUT99425.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364107}.
CC -!- SIMILARITY: Belongs to the SCC2/Nipped-B family.
CC {ECO:0000256|RuleBase:RU364107}.
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DR EMBL; LN902845; CUT99425.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YA34; -.
DR eggNOG; KOG1020; Eukaryota.
DR OMA; IPTHRET; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0061780; P:mitotic cohesin loading; IEA:InterPro.
DR GO; GO:0010468; P:regulation of gene expression; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024986; Nipped-B_C.
DR InterPro; IPR033031; Scc2/Nipped-B.
DR PANTHER; PTHR21704:SF18; NIPPED-B-LIKE PROTEIN; 1.
DR PANTHER; PTHR21704; NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED; 1.
DR Pfam; PF12830; Nipped-B_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU364107};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364107};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364107}.
FT DOMAIN 2289..2531
FT /note="Sister chromatid cohesion C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12830"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1250..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1372..1405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2782..2997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3020..3057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 26..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1259..1283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2788..2811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2832..2864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2878..2914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2961..2975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3025..3044
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3057 AA; 331393 MW; 33F08C6F42E32162 CRC64;
MTSPMKSGFP SATRHQTLGS PVAPVKLTLK QSQTPGSGSI YSVTSVEPLK LSIKRAPATS
TPVTVTQGGL KKLRVKRRSK ASTISSNQKW PMQLAELGSA PVVPTQSQIV HSHSVQSTRL
PAPNPSPSLQ LVISAPSSTL PPPPPKDPPA RNSGQMLSTV FNQLLQSDPE STIASLLSSS
DGQSTGNPAS VEPHHPRSPP LSVPSNCSYP ATPGMNSSLS LNNNNSSTSN VAPVAVTSTT
NPSPINTIFD TADVSDGRET NPTPAPPPPP PPRGLAAYLQ KSRNPEMAAS PSEDVVDAYA
RQHGSVPPMS SLSSSPWTER RCGPQATSNA NIGAAVYPTS SSLTGTPNGQ EGGKEKRGRR
RRSELEELIN WQVRDQATPL KRHAFQSQQI PPIIENSPPP PRAPSDNEGV AFFTEPLGER
VKRRRQQHTT PLCSSNSTSD VTRNTSGSKS GDGNGGKSGV TKRSREGTSS ELSVSPKRGK
TLNHRHHRLT SSESEIPDDD EEEEAKGVDD GATSSSCLTD SPVPRKHSLQ RLVEEAKGRP
PSLSRLDSLR HTPVSSTPIP LDETVSPLAR LNSNRLSPSM ERPRKRASTR SSTSPPPLLP
LQTCGQDLVD RKERHRLKKR RQLIQATSSS EDEFSKKSSH PMVIAERNSK RSSSHNRSAE
MSTSRAHVSC KKQKGPLICS SSSPSSSSSS NACRLSPASF SKGHRKTNSD ARSCSSEERR
KPIPQRCEST SGTEPCTESS AMDYDRYEKD ELSSLKALSA TAVAGGVASS RLSPSSSNIA
ASSDLSDSDR TEMVMEAEKR IAEEVAKFAA TWTHFSAHIS EFLLRVGGLD LSKTAGDMCI
AAVDPGEDFS SVVDQTPVEA RLSRREVNAL YHEAEEARVS GFISNEPNGR LVRFLNLLRV
NIRDASSLMA PNPTVANFKE LIQRRKARIE RRNGGTEGNS GSSELLSESL LWSHPVWMRI
LRGLDSALIA LHIIAGPDVP RSRLLAMEEL VEAITAITHF HFNRLVTVIC TPDESKRSGS
NIPVGLTNLV RESLGSRLSE ALCGLASLVR LHPGRFTDSL IMHLTDLAIL VISCGLSPGT
SRRSPPPGTT ASSSPPSTIL FPETAPHPVP GESLERRERR QKEYYERNAW RLQMQRSALA
LASIIFLQYD KHRRLVASDV LSNLITAPIK AVSNKTSISS FARSCSAMRN FWILASGSFT
KGWQPFCRNA QTSSSSAHNF VANSHFLRVH PFTAVLMALI QGLIPAPSHM AGGRRSSSAG
APATPSSGVS QQSTTTGTGM SDQHANIDAT QLAKEEKSMC SAYTNAIRTS QFLISEMFRK
AVAKGEDNLS PLVDTVLIDL LRVAADAPIE WPVASLLLTI FGKFLIQQLN GSSTTPSSSR
SQTPTQGAAA SATASSSTTT SASNRNADSM ARQIALDSLI TLTGGMYYLQ KLRGSVNKSN
FDLGEARRAL STFLGSPILG LYHLTLGIAD ESKADAASAL AGGLPNHARQ RDFAYQLISR
LRYNHFDGLT VAAKRFHLVT WLHETNQELS STTPSSTEER RKQLEEIRKG LLMEFASTHH
SISGIAPWLP PTRGAGSGGG GGGATSNRAG LISPAASEPS IAGERPLSDT KLALYTGYGV
GADIRHKKTA RAHRFATKIA AHIYNPIGFD VLYMQIVKMV HDASLVVRTR ALKGLSNLVE
TYPECIPAPV ITESPTPSPS DLLSIVPLRL MDGSPMVREA AVELAGHLVN IPDSAFPSRL
FKPLVNRVLD MQLSVRKRAA KSLQQILLSN CDDTLRTPLL TSKQRSDACV TLLRRFNDED
AIKKIVMETF TALWFTFGTG EDVDASKLAV RLEKRARNMC EVVLSVRGRG SGVVEEFMAS
ILNQESPEKA VQVDAASSEI VDFLLKIVQR YHNASWHTAS CPLHPKHNRG RPCSPEAHCK
CSTQPPDVLS MQNVCLVLSI MAKPRPQLFL QHIPILAEVV GFAAVSQDNG GVLDGNTLSY
AIEIIESCCR HAAAERGSRL SQLFPDGTDA LEDYLIVLLQ RHCRVVVDSS VACLAAIAAQ
LTMNYSRVAT CFAQFYECLI QERKAATERL RRLTSKHTAF ASPSSSSSVS SLRSPLKARP
KVLRAVYAVG LICKHFSLED LANAAVKLSN ESNTGARRSS IGLSILTHQA NIGTNNRDEV
FNTLMFFSET ALLMNIDEEA RRALTTTSNE DVEMAKKAVA GLSFLANRHD YLFRSPRLQE
FFKSILSGVS ATFPQQAVAD LQCIVLDCIN AFLIDEEKTM LSNDSNWLAR RKQESLKDLG
DSQEVHGGTV AQIYLKTALE HCIICPSTTV RTKALSLVAT AARQGLVHPV SFIAPLISLQ
TDPDFAVRSR AISILQEISQ RYSGFLALKA AQGIRSGFLL QRMIASSLNK QQTIIRGAYV
GKAAATSTSS CPDKTDVSSA QARPLALSHP TYSLLQGNKQ HRRSLITSLV NLFDMDYIPQ
PASQAISPYI SMAPDVAVRK SAFTLGATET DVVDATSEDN GLSELIYVCD HLAHFPYKTV
DEVYYLAHYL DLRISTIGSA LVRSLQDCLV STSQLKAESS AVSTDVDAAT EPPSLIYDRK
VINLLEDVES ELFAKPDMPL EVGLNERKAI DRINRPVAAV KRLAFREKVF RNGPACLLLM
AIRKYLEEAY DVTSNKLSSY SSTDEKHLQK PIPSPSARTL HSGVLYQLVE IPAIVTSCAL
NPAWPVVSPS LKEALVRDSG AGDAANLDIN VLRVALLVHR QLLTVDGSDE ALGMEIAPPP
SPLLPPMPRP SIGPNGDVVQ SKRAAAAIPT HRETERFREK SHSDHRISTK IPTKSGHSSS
TKHRRVGENV SEDRTGNLSD SLSSLSDTSS VRKMAGGTKQ QSAFMRSTEK KKRRQPSCSP
SIKPSKHLNK SNPEETSTLS KHNITSASMP KKDTTTKSSS RKRQHNLSDT ELSSLSSLEE
DPALPRKPAK RPPQPSPSFT KKAVAAATTS ASAERPVFSR PKYDLAPLPG TPDILTQQEQ
RRRMKALAAK KAVAKHLLME TAKKKSQPAQ PSARSGSFKR EASSQSELSR VHIDPDS
//
