ID A0A068YCK8_ECHMU Unreviewed; 1797 AA.
AC A0A068YCK8;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Protein son of sevenless {ECO:0000313|EMBL:CDS41010.1};
GN ORFNames=EmuJ_000862200 {ECO:0000313|EMBL:CDS41010.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS41010.1};
RN [1] {ECO:0000313|EMBL:CDS41010.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS41010.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902841; CDS41010.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YCK8; -.
DR eggNOG; KOG3417; Eukaryota.
DR OMA; LHEFELY; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 1033..1176
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1237..1506
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 316..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1366..1394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1619..1721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1736..1797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1599
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1638..1677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1678..1701
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1702..1721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1756..1781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1797 AA; 198838 MW; 64A3DE86588D1A58 CRC64;
MASSIARHTS TVSLISTASV PREGGALAQA LNRYRDQIEA ACDKILEKCC MDNKPSAPGD
RESAASQAPR VLEDRAREIL TQYLIELLSS LVLPEPLPQS IRDVNARLAE GQLCFPDKLM
PTKAELEEFH VLAEKGKKVL FASLDLPVDK IFAALKELAG RFNYPTCIYI TAVTEKVISN
FLKMVVYFEE RARSEHVISA VTIQNIFQFY RDRVRSQRKQ LDIMFTNNFP QDYNKCVNEL
VLFLSSSLEQ MNLILRVFRE PILHSPVCAS LHVGSEEAAV REVFRDALDL YNNFRLLLDY
LESDCADDLP FTSSPFSNPI PSASQQRETD DSSCRTTTAT TENRRLVGRL LIEPAEEIAL
ASYSDSPDPF NNIWRLSERN DVLESLARSS RAIVHTVSRL KTTSTDVTDS RLACLHSLCC
PSCRMWDQKE YPSSTAKDVS PPSYNCNALI NCFRYLLPRL LFLPIFQFFH FYRLVHALHQ
QAYDSEDQKL LMLVVDYLLS ARLNIKSVLS RYPDLHVQLA RLVTTGHLVT AQTSTAPSFC
SHQVISPTGI NSHHRSCSAS PATSMTPPIR RNSSTQHQHQ YYRCNTPPLP PQSQPLPPSH
QTPMLALSAV FFAGGGYTAS PFVVGTPTTT VSGSGTTTVV SEEEVEENVD SMMSTLMSGG
VCGVVTKAKL EELERLTGGK DRLLSASVAS STMGKFVMEG RLWVRDEGKR VASERQAYLF
TNCLLLCKRM ERRTTLAPSM VAVAGTQPLL RVKRRLPLEA AHVIDCVVPV RPRPEAFTGS
HPHNSLAECA SLLSRCPVSD SNQHLHTTVE DVEQCSFSLE FFGTDQRQLC TTSDGVGGGD
GSSAASALSN GGLEMLQGVH FHYLHLETSC LEEKADWMAS LLSITTSRVF ERYLRTLPKL
EIPLRLPSPE KYRFAHPDTP EVIVFESAAG QSSGTATITH RLLQPSLSSR IRSSPTTASV
DDPFDSFDEL DDEVEVVDVE FFPTTPTDED SLGGADEDLA LPLPASTSSR IHSPHLSSQI
LTSSGIPSLP SHHRPQIQYA TLEKLIERLT YPAYFDAEAV NAFLISYRRF ITPEELLDIL
LERFNVPYPD FTAEERQTES VVEHMKRRFR SGYKRWVQAR VVAFLFKWAS SPRYFAYDFA
PNADLRARLA TFLAGVRVRI LLPVVQAIEH VLTRGDSITV PVTPITTSIG VAVAITEPKG
HHPVRLRATA TVDSQQLSQP PPLFSDSFPR IDLLQIHPLE LAEQVTLHEF ELYRRIEFWE
VDGRERSSQD SPNLSACKNF SNKFRDWLVY SILSERNFED RVVAIQRIID LMLIFEHHRN
LQGRQESKAV LLSAAVFRLK KAFEAASRVR PYRKWVQQLQ REGRGSARRV TKASRGLEGG
EGPTSVEKAS TAPTTTASPC LPYIAMRVST QLIHLELHQP DRVTPTGAPF DDTSTDAGTG
GLINFVKQRR LAAIVERFLQ HQLVPYTFPF KLRIQQALVA SLEAFTPEDR DFEARMYALS
ESYEPREPLS EPPQPAPEVE RRLSKEAIQA ANYLGGLSLK DKLQHEQVAT YKAYFSPRQI
KSSGRVSSPR LSSPPNSSVP VPPPPPSPPL LASAPAPPPL APAEQRVVVL WNTRLRQHRA
GQQARLTPAH GVATPLPRPL SSPTTASSTG VIHHHCISDG QMESLSNGRL PTCTVPPLTS
PLSSPPPPPL PPPPPPPRRQ SSSGPSTSSP ASASHSPSPL FPLTTVLAST LAGEGAAAGV
DGGLPPLPPK PGQWTSSVAA GLSPSASSSN PSRQFFDTLH PENLASTPPL PPRRHFS
//