ID A0A068YE19_ECHMU Unreviewed; 723 AA.
AC A0A068YE19;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Cubilin {ECO:0000313|EMBL:CDS42987.1};
GN ORFNames=EmuJ_001071500 {ECO:0000313|EMBL:CDS42987.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42987.1};
RN [1] {ECO:0000313|EMBL:CDS42987.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS42987.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; LN902842; CDS42987.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YE19; -.
DR STRING; 6211.A0A068YE19; -.
DR eggNOG; KOG3714; Eukaryota.
DR OMA; LGDYERC; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR47537; CUBILIN; 1.
DR PANTHER; PTHR47537:SF5; SOL-2 PROTEIN; 1.
DR Pfam; PF00431; CUB; 3.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 585..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..162
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 179..320
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 392..536
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
SQ SEQUENCE 723 AA; 82516 MW; BB1B0F3D084E7105 CRC64;
MKCIPFPKIT KECLKICQWQ LNVVHYCQCH LFSSVKRLHG VFKSPNFPSP YPPQTDCIIY
LFQGLPFQIV QLTFLTLDLS PPRIDICFDY VAVLHNDRTR LVDRKVADSD PPPVLCGTLT
MQKKRTFFSE SNSLALVFHS TTRAPFEQST HMSGFQGNFL FLNSSNFRVD GDRLPDSKCS
YLIQNTPTRR LIAGGRIVSP RYPNDYPPNI RCSYTFMGRG DERVVMSVQS LLLSHRDLSN
PSNSTTQSCI YETSLLSSFD RVLVHSLPSD RWREANLLIR ICGTLNSFQI ISEGPNLQLT
FISLPFRPKD GGFLIEYVFV KRSKVSPRLW TATTAVPFEQ RAIKESVREF FDYLKKLQKV
SLPKDAADEV VLRTPSNTNI LNSDSASLQQ GCNAPEVLEM IIDSHRTEEG VLTSPRFPEL
YPKCVNGTYY FRGRSGQRVF LKFVLLELGD YERCDEATGQ SGDRLYFYDG PSIELPVQLS
VCGSRQSVFR PETEQHQAST RSLAIASSGS HFTMLFISDE FVGKFEFGFR LEYRFQHLIT
WEMVANQKLM ANNSLKSKKE QVVYFNYHLQ TLSTSPTSKI STAALNLYII FGYLGCFYGV
RPFAFLSYFH QTDENRRGLS SNADISLLHL RLVRMESFTK IKREYQTKTA HAFTVFRTYE
ILQIKVSNGS GQCISTKADQ NVLKKFLFTP IPTYLFHSVC GSLMPRTRGS ELDKWKGTSS
QSI
//
