ID A0A068YEE3_ECHMU Unreviewed; 4700 AA.
AC A0A068YEE3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:CDS40726.1};
GN ORFNames=EmuJ_000832000 {ECO:0000313|EMBL:CDS40726.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS40726.1};
RN [1] {ECO:0000313|EMBL:CDS40726.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS40726.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; LN902841; CDS40726.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YEE3; -.
DR eggNOG; KOG3595; Eukaryota.
DR OMA; NERQMTR; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1918..2056
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2231..2556
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2617..2767
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2959..3125
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3243..3284
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3433..3488
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4700 AA; 535199 MW; CB01061147179DC5 CRC64;
MVDPSSDVQE RSSEVQVVVA DKTLFENYIK NIVAAFDGAE NATALDKAIS DRSAQDAIGR
FLSDGQCHAL LVRKSSSKGT IFLINPEHLD DDDESDGADP TFSYTISTDV HYTNPKIQSL
VFIKQNLVVE AGKSFASQLR MSTLCDGAPF ETLHSMISNV VSPYYKSYIK ESGKAERDGD
KVAPSVEKKI AELEIGLLHL QQNIDIPEIA LNINPTVLQV IKKCEEERRR AKVSDFEAYL
QDSSFLNSLQ SGVNRWIKDI QKVTNLNRDP STGTALQEVT FWLNLERALS RIQEKRSSLE
VTLTLEILRT AKRFLATVSF DSDTGLTRAI DMVNDYNPLM KDFPLNDLLS ATELDKIKLA
LQAIFTHLRK IRNTKYPIQR CLKLIEAISR DLTSQLLKVL GTRRLMHMPY DEFDHIMTAC
FDVFGVWDDE YEKIQSLLRE ICKKKREEPL RMVWRTNLAH RILQARLDNL RKLWHQHEQL
RLVIVRVRPT TRTSTTQPET AKAKMVEDEP KQHHDEPLLD AADANAIDDV NKAFELVKEV
DCLDLSKEGM EVWDATIKRY EERIDGVETR IAARLRDLLG TAKSANEMFR YFSRFNALFV
RPHIRGAIRE YQTQLINRVR EDIEALHEKF KNQYRFSRAS RLSKLRDIPP VAGSIIWARQ
IEERLNTYLR RVEDVLGKGW EHHREGQDLK SNGKDFKAKL NTNGIFDEWC RKVQQNQFNA
TRRIFCVEPV RVKIPNKDGS TQTTTMMKLA VTFVLDVITL SKEVRCMKAM GFRVPLSIVN
RAHQTNILYP SATSLNQSVQ IYEAICAKID ANNAQNLAIL CAGLRREAQS LISEGVQLNW
DSYRLSNFVQ KFAEAILQFQ EKVEDLLQVT REIDLQLKAL VTCPYSKESF EEIIGKIQKL
VDDLNLHKYS NLAEWVAKLD VEVENRLITR LEAGIREWTR VLHTDEKQSG ETEDADSSMS
TSMVVSQQRL GGEPKIKQIF LELRITNQQM HLHPSIEVAS HELFSQLTAW QNIILNLPRI
QHSRYQVGFS TDEESQKFNM NLISRLSKES DVLIHAHDAI FGILSETEEY VKTWTSYQAL
WDLQVDQVYN RIGTNLEVWM NVLDEIKVMR RHFDVAETQK AFGPIVIVFD KVQSKVTLKY
DSWHKEILSK FGSNLGSEMQ DFYKQVSEAR TELEKRSVDS KSTSDAVNTI TYTQSLKRKL
KQWEKQVNLY KTGQNILYRD RFQFPNNWRD SENIQGEWSA FQEILRRKES SISSEVASLQ
MKIVTEDKAV EGKTAELLNS WHKEKPIQGN MKPDEAVKAL TILEGQFLRL KEERVNIQRA
KEALELTEEG VLPPSEERVN VALEELQDLK NVWIELSRFW EEIDQLRETP WQSVQPRKIR
QQIDEMVRRL KEVPARLRHY AAYEHIRHTV QNFAKVNPIV IDLKSEALKE RHWRTLIRKL
NVNWVMSELT LGQLWDIDLQ KNEAVIRDVF LVAQGEKALE EFMKQVTEVW KTYELDLVIY
QNRCRLIRGW DDLFSRVKEH INSVEAMKLS PYFKQFEEEA LTWEDRLNRI NALFDVWIDV
QRRWVYLDGI FSGSADIKTL LAQESQRFSS VSTEFLGLLK KVSKSPLVID VLNIPNVQRQ
LERLADLLSK IQRSLGEYLE RQRSSFPRFY FVGDEDLLEI IGNSKNIPRL QKHFKKMFAG
VNAIKLNEEC TEVLGLISKE GEEVDLVHPI SIKDNPTIND WLSLLEKEMR ITLASYLGYA
VAELQKLRSA LELESSGFLA WLDRYQSQLV VLAAQICWSE SVDAALNNPK SSDSLTACLR
SVETMLTLLA DTVLSEQPPI RRRKLEHLIM EHVHQRDILR VLIQAGVNSS QSFEWLSQMR
FYFDPKQSDP LAQISIHMAN AKFAYGFEYL GVMDRLVQTP LTDRCYLTMT QALEARLGGS
PFGPAGTGKT ESVKALGMQL GRFVLVFNCD ETFDFHAMGR IFVGLCQVGA WGCFDEFNRL
EERMLSAVSQ QIQGIQEALR DQSTGKDVTV ELLGKNVSVN SDMAIFITMN PGYAGRSNLP
DNLKKLFRSL AMTQPDRQLI AQVMLYSQGF RTAELLSNKV VPLFKLCDEQ LSPQSHYDFG
LRALKSVLVS AGNVKRDRIK RIKDELHSKN EAINESNIAE HLPEQEILIQ SIMETMVPKL
VAQDIPLLYS LLKDVFPGVS YSASPMEDLR RELKRVCEEM YLVYSDDTSD SGTGGALWVQ
KVLQLYQITC IHHGLMMVGP SGSGKSMAWR ALLKALERVE GIEGVAHVID PKSISKDSLY
GYLDPNTREW TDGLFTHTLR KIIDSIRGES QKRQWIIFDG DVDPEWVENL NSVLDDNKLL
TLPNGERLGV PPNVRIMFEV QDLRYATLAT VSRCGMVWFS EDIVTPEMVM TNFLRYLQNV
PVDEDEDADL SFAVSASLTA PSAGGDQVVS SPVEGAPVSV SPTVQTQRDI ANMLVPHFGS
SGLVSRCLEF AKDLDHIMDF TQLRALTSLF SLLKQAVRAV LVHNASHTDF PMPVDQMESF
VSKSLVNGII WSMAGDGSAN VRMQMSDFVR QVTTIPLPPP GMPIIDYEVA VTGEWQPWIN
KVPNIEVESH KINTMDVVVP TLDTVRHEAL LYTWLAEHRP MVLCGPPGSG KTMTLFSALR
SLPDMEVIGL NFSSATTPEL MLKTFDQYCE YRKTPNGLVL APQQINKWLV FFCDEINLPD
EDKYGTQRVI SFLRQMLEHS GFYQTSDMQW VRFERIQFVG ACNPPTDPGR KPLSHRFLRH
VPVVYVDYPG EMSLKQIYGT FNRAMLRMLP TLRSQADALT NAMVDFYLRS QKRFTIDMQP
HYIYSPRELT RWVRGIHEAL KPLESLSVEG LVRIWAHEAL RLFQDRLIQD SERLWTDQNV
DEVAMTYFPF IDRVAALQRP ILFSNWLSKD YVAVDQEALR EYVKARLKVF YEEELDVPLV
LFNQVLDHVL RIDRVFRQAQ GHLLLIGISG AGKTTLSRFV SWMNGLSVFQ VKVHNKYTAE
DFDEDLRNVL RRSGCKGEKI TFIMDESNVM DSSFLERMNT LLANGEVPGL FEGDEFAALM
TQCKEGAARE GLMIDSQEEL YKWFTNQICR NLHVVFTMNP SSDGLKDKAA TSPALFNRCV
LNWFGDWSLE AYFQVGKEFT EKLDLECSDY QRPEVMPYVA EGLLPDMPTY RDMVVNAFVF
VHQSLQRANE RLQKRGGRTM AITPRHFLDF ISHYVKLIGE KRSDLEEQQL HLNVGLQKIR
ETVQQVEVMQ KSLTKKSKEL EEMNEAANAK LKQMVKDQQE AEQKKTTSQS LQVELGKQRE
YIKEKRALVM EELSQVEPAV NDAKQAVEGI RKKDIQEIKA MRNPPPAVKM ALEAICLLLG
EKSTEWRQIL TVIVKDSFVP SILNFDTEEI TDSIRETMKK KYIENPEFNY EKVNRASTAC
GPMVKWAIAQ IGYADILKKV EPLRDELKAL EDAASVNEKK AEDVEATIET LEKSIARYKD
EYAVLISQAQ SIKADLASVE AKVERSVALI KSLSSERTRW EAGSETFKSQ MATIIGDCLL
SSAFMAYAGY FDQSLRLSLV SSWAIHLKAA GIQFRPDLAR VEYLSTPDER LRWQASVLPD
DELSVENAII LHRFNRYPLI IDPSGQAIEF LMEEYKAKKI AKTSFLDDAF RKTLESSLRF
GTPLLVQDVE SYDPILNPVL NREVRRTGGR TLITLGDQDI DLSPTFIIFL STRDPSVDFA
PDVCSRVTFV NFTVTHSSLQ SQCLNAVLKA ERPDVDNKRS DLLKMQGEFQ LRLRHLEKDL
LQALNAAEGN LLDDDKIITN LETLKKEAGE VAKKVEETDA IMAEVDNVSQ QYVPLSQACS
GIYFTLDALN QVHFLYQYSL QFLLSIFNVV LTQNENLKGV NDSKTRLDII TKDLFQVTYN
RVGRGMLHSD QITFAVLLAR IYLKGKASAG VTFESEFSVF LHGQNSASLL TSKNLPDIKG
LTVEQRAALS RLQTQLPAFR NIVPAIRNEQ RFNAWLETVS PETEVPTLWE LSAAQTTPVG
TAIHSLLLIQ ALRPDRLLAC AHMLVFAVFG QGFMDATRAN LDLGSLVEQE IKANVPVLLC
ATPGFDPSGR VEDLAADSKK TLTGIAIGST EGFSQAEKAI NAAVKQGKWV MLKNVHLAPS
WLVQLEKKLH SFQPHPNFRL FLTMEINPRL PVNLLRSGRV LVFEPPPGIK ASLLRTFANI
STARMSRAPA ERSRLYFLLA WFNAVVQERL RYAPLGWTKR YEFNESDLKS ACDTIDTWVD
SASKGRSNLP PNQIPWSAIR QLMSQCIYGG RIDNDFDQTL LDTFLSRLFT EHSFDHDFVL
VKDVDGQAGK SILIPEGTSR EELVAWIKKL PAVQTPSWLG LPNNAEKVLL TNMGQEVIGN
LLKMQQAVSA DDSLSASEVA ATTLVKRISV DEGDTRPTWI RQLQSSAETW KSLLPDRLRP
LERTAENIAD PLFRCFDREV NAGATLLNTV RDDLRNVIKV CSGTIKPTNY HRDLMSDLAK
GLIPASWRRY YTIPSTLTVI QWINDFAARI RQLIEISEAA SSTDYGSLRG MQVWLGGLFM
PEAYITATRQ AVAQTHGWAL EELFLSMELV IGAQKERPPP LPADGCSFVV SGLRLMGAEP
ADAKTICLSH SIFYEMPFTI LKWIRVVRDE QGVIDANTVK LPVYLNAARS VLLFTVGLHT
REPGSEFYKR GVALLSSPLG
//
