ID A0A068YEN2_ECHMU Unreviewed; 1750 AA.
AC A0A068YEN2;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 08-NOV-2023, entry version 39.
DE SubName: Full=Synaptic ras gtpase activating protein syngap {ECO:0000313|EMBL:CDS43242.1};
GN ORFNames=EmuJ_001098100 {ECO:0000313|EMBL:CDS43242.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43242.1};
RN [1] {ECO:0000313|EMBL:CDS43242.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43242.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902844; CDS43242.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YEN2; -.
DR eggNOG; KOG3508; Eukaryota.
DR OMA; VILQCET; -.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF125; RAS GTPASE-ACTIVATING PROTEIN RASKOL; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}.
FT DOMAIN 871..1062
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 776..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1347..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1663..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1609..1643
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 242..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..751
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1279..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1418..1436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1663..1677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1750 AA; 191381 MW; 4CE76F74E2201A9B CRC64;
MPKASSHGRG TSITASKSIV CQQTSTKTTT ISANLIRARS STIHANNSTF TTRSSTQLNH
NESAMSSSLH ITKTSTLLSL PSGENNSKSK TPPWFWQRKN TSRNSLFRSA SANKANEGGA
VGAGGWKNNC ERPSADKAYE SETSTLGSTI ANDGVSATTR NQSIIRSAST RETKPTGGFL
RFLRVSFSSR AKKPKDFGPG TPPPSMTQSG LGSLAERQAS IAKVFADPNN RLSKHILRFP
KDTETSNSVE SFDSAASGES LSSSDGSQQP SVGLCYSNDK PPLRATKNTA RSHSAHTRPP
KCQPSQPTGR EQRATNIYTN EVDAEVSMEI IRQPPVFSGI NNRPQRVMHA LITKQQPAET
SRYDSNAYEN TFHAVPGVCQ PESIPMHYFQ AYYPQSHFNS TYSDGQIYDQ PPAPRPKEMR
TPRNTQNSGN NSQYCNESLI PRMIPPVPPA TAPASRRRFG RSNYESEEIS GDEGDEEEDE
SGSGRGGTLS RKRPAPPIGV LTNRYSRESL NCKDAHEKTP VPRGTTPARA TAPPHPLPNL
PQSALKTRLT RRQTVGAIQT LAQSSSNPEP TQGSLHLKRV VRPDLEQERH RDTSLRITIH
ESKNLPSHRR YFCDICLDRK LYARTTSKLS KETVFWGECF ELNNLAELNF ITINLYREAE
SAKDASKRRK SSKAQNQLIA FLTIAISDFS SKYETQQWHT MTPGSMLPSS ENLHTNPISP
RSSIRQSIGS FNNPDSPQCN PDTSTGCSAK RSISLVGPPP TTILTGRIRR LSKHNLGGSE
SRMNAGQNSS GSSGSGASSA LLPQIRLAVK YQSIDVLPLY CYDNLRKLVV EKSTEFVRYL
EPLLPTKRKE EIARCLVNIH EKTPESNIAA FLASLVDHEL DTSDNLSLLF RSNSIGSKAV
ECYMKLVGAE YLRKLLQGFI ENLLTSSEDL EVDATRLTRH SWSPASESGD VSAVTDSDAS
ILQRNRIALT TCVKTVLQRL QASLAYFPAN LRETLASIRR TVEQRHGQEV GDQLVSGCLF
LRYICPAIHG PTLFGLTNAV PDDPRVSRNL TLLAKVLQTI ANFSHFEAKE NYMRFLNSFV
QSMQEEMHQF LRAASTLDDD DDTSEIWKRQ NTNVSNCHSN IDLGYELTVL YGHLSAILKE
HPKVPDCLAE LPDILAGIEH MLSKPSLRRS LSNLANSIRS GTSASLEDSA AIRNSAFRFH
STVTPPLLNE QQIIPAERPS TPVSFGIPGE DYTSKCVSSG EEPRCSLEIS SPSSDGVTRQ
QAFFGESFEP GAENSKGADL ESISETEVQT SSPVNKISTS PTTQLGTCTT ANGGHYRSAS
VQRHKTPQTS ASLHRCKEVE KCCTGNGGGT STANTLPTPP QKWSSGPELH ADSPVILNFP
PPPPALPQLQ NDKGLGGSST NIRMGTRALR MSRERDLTGN IESGTSTRNG ENGRDDAQLS
TVPVILQCET PVVTGARTGT TVHGAVNIGG GDGSVLSVDS TPSYDSSTAS SSCLSIMPHA
NNVSTVGANG RGQGVFVTEN AHHFELPTNR STSAVIQRGS RISCSNTNTT NSNKNDPALL
SRVHHLLFGG GSGSGNDYQN VRGIVRPAPS ISLSMKFEEQ REKKEVDPRK AESTQLEALQ
QRLRAIEEHL NQERRDMQKA VASNMRMMES QERCINECCH RQHKSSCPST SNIDHGNEPP
KRSSRINIVF AKATVVIELV VVISEISFNT ERLSPVPQPQ WYPLPLSVCL TTRLSVQVFF
PDKGEPDLSS
//
