ID A0A068YFX4_ECHMU Unreviewed; 1060 AA.
AC A0A068YFX4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Unc 112 protein {ECO:0000313|EMBL:CDS43454.1};
GN ORFNames=EmuJ_001122100 {ECO:0000313|EMBL:CDS43454.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43454.1};
RN [1] {ECO:0000313|EMBL:CDS43454.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43454.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902848; CDS43454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YFX4; -.
DR STRING; 6211.A0A068YFX4; -.
DR eggNOG; KOG3727; Eukaryota.
DR OMA; GMFFCAP; -.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17095; FERM_F0_kindlins; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR037843; Kindlin/fermitin.
DR InterPro; IPR040790; Kindlin_2_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16160; FERMITIN 2-RELATED; 1.
DR PANTHER; PTHR16160:SF13; FERMITIN 2-RELATED; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF18124; Kindlin_2_N; 1.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
PE 4: Predicted;
FT DOMAIN 106..861
FT /note="Band 4.1"
FT /evidence="ECO:0000259|SMART:SM00295"
FT REGION 214..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1060 AA; 116976 MW; 34DA98D007D63D1E CRC64;
MISDGGHYVD GSWLLSVRID SLNVDREMRV KGDWSIGRVL VGLIEGLAHP QKLACEASDI
SLSPGIINSG WSDFALWWPL KNRWILQTHA SLDQYGLQAD ARLHFIRVHG RLRVQLPDLQ
TRVFCDVNFT EPVFRVVILI CKHLGIAHPE ELSLQYPDFD RFCNPVHGKM PSIWNEQWST
LPASARRSFR KLAFTSPSKT GLRQKRPASC IISSTDQTDK PERNVITNNQ TMPRRPQVYG
PPRVRNRPIS GNSPLSPPRP DSVYLSQSLC GAPLSKLETC DDPSLVSSPQ MPLSEALTSG
SIQRQRGFFA RARFSNVWLE LGRSLMEQGI YPATLNLDDT LDSATINLET ERKENGVNGV
QTDTIPMLRL RFKYNAFYDL TRKNSAVRIN QLFEQARWSV VSETIECTNE EAALFAALQL
QLRQISSSSD PQSSSREPRS FSISGEIVEV NGHSRSISPP LSQPVRRPSS SFGSDAFISR
PANPSVQDLE HEIDLLLDDL TTTCLQQDRS NLIRGGPSST HHFPRRFSTP YRPRWERNNR
NGGGVEVSLP ELAAYLKVCK PRAFGIKTYR RFYVVLKKTS LLMFKTQEDC QNSQPPVDSV
CLLGCESWPD LSPTSDRYAL RIFTPLLKQA LPLSSALRAD SGVVDGGVMG DSDSVSLTTR
LKRRASLLSL TSLGGLNAVC GRAVSRASGL LNELILRLPD EAHYVEWAAA VRLAGSLSLG
CAGAATPETV RRLFEAEKRA TTSLLQLLTP LPMKITSLRT DSKNPVGAAE RLWLLQNISV
ILPYRLAGEQ AGGGGTMQSK ASEPIAPNTG ALSPAKEEAN ERLVRHIMDI RGRLTEMSTT
EVKLQYIGHW QQLTGNGVIY FVARFETSVP VATALGLPAD TPDQAYSTLS FHSSHIHPTS
RQVTISFSRR DEVVGIGNGR VARHDLTTGE IHAAWRLEMI QGWNVNRELN ELVLMLAPTA
TSPSTATTTT ATTINTTKSH PIPTSFPSTG GRVVIRPIGV PVQKVSEVLG ANVFLSLRSP
TKSQELDEAL FYRLIGASPM KSLYANITPA STTAATTLPR
//
