ID A0A068YFZ6_ECHMU Unreviewed; 984 AA.
AC A0A068YFZ6;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Non lysosomal glucosylceramidase {ECO:0000313|EMBL:CDS41144.1};
GN ORFNames=EmuJ_000876700 {ECO:0000313|EMBL:CDS41144.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS41144.1};
RN [1] {ECO:0000313|EMBL:CDS41144.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS41144.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902841; CDS41144.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YFZ6; -.
DR STRING; 6211.A0A068YFZ6; -.
DR eggNOG; KOG2119; Eukaryota.
DR OMA; TSPVMEN; -.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR006775; GH116_catalytic.
DR InterPro; IPR024462; GH116_N.
DR PANTHER; PTHR12654; BILE ACID BETA-GLUCOSIDASE-RELATED; 1.
DR PANTHER; PTHR12654:SF0; NON-LYSOSOMAL GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF04685; DUF608; 1.
DR Pfam; PF12215; Glyco_hydr_116N; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
FT DOMAIN 83..457
FT /note="Glycosyl-hydrolase family 116 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12215"
FT DOMAIN 586..963
FT /note="Glycosyl-hydrolase family 116 catalytic region"
FT /evidence="ECO:0000259|Pfam:PF04685"
SQ SEQUENCE 984 AA; 110196 MW; BF799497840680C9 CRC64;
MSVSAISYAE KIHLLPTYGW KKRFDECPSK NAGPSKPRSG ILMSNLPDIP RYIIKSQIPT
EYRKKRLLPI DILNPLTVPS TYGVPLGGIG CGTIGRGYKG EFCRSSLIPG RFNYDVGAAD
QFILTVWKAG TCVYHQVLST SGPAKGVQGL HSWKWSMSPQ VGNFIGLYPR SWTVYEFLEL
KLLLICKQIS PVIPEDYKDS CLPIGVFHWT ALNFDPESDV KISITMSWRG PRAPKRPLPP
KVGTAGAVCA EIGHLRKHKD DEFTFPFDDS DNQLSGCLLE TFIDDMPCCF GVAAKSTDKV
EVSRCMGFTL GCKGAGSASS KQKTTGKESY RSPWGITTHS MASAHDAISS SKLWTDLGQE
GHLAFENTGY YVEGKDKNHP LIGFAVCASF KVVAAAGGKD DLVPGQEACD FFLTWHMPRV
HFRSALIAYR RRYVRWFSED IIRGASELLI YASRRAHLWD EAIESWQSPI LQDSRFPTWY
KSALFNELYY IADGGTVWLD PLPAEGSAGV IAEGDGSAAS SSNGVTGGTE ELCSPLENVR
HRNPTVHCRR PAYYSTKAPA AGDNAPADVA EIEFIRARVN FGNEMGLFAY LEGHEYRLYN
TYDVHFNASW ALLKLWPRLQ LAINYDLADM TASEDRSPMK PVFRGTHDKH RILSYALSVP
HDCGDPEDEP WYRVNAYTLR ATDEWKDLNP KFVLMTWRDW KVTGDDNYLF YMLPLIVAIM
EGCLEKWDKD EDGIIESANF PDQTYDMWKA VGLGAYIGSI WLAALYATKD MISYTLSKER
NPVKNETLSG QEHKFGELLS KAKTNYYEKL WNGCFYRYDM HDSKANPAIM ADQICGHWLL
RTCGAPVDAI LPENTIPLTI DSVVSKNWRS VLDGEMGAIN GVRKNGKVVS NVQAEEFWVG
TNYCLASLLI LEGMPINGFD LGAACYKTVY ENLGLQYQTP EAYTMEKGYR SPAYMRPLSI
WSIQHSADLR RLCRNGSSPT RTTD
//
