ID A0A068YG58_ECHMU Unreviewed; 1046 AA.
AC A0A068YG58;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=SH3 and multiple ankyrin repeat domains protein {ECO:0000313|EMBL:CDS43505.1};
GN ORFNames=EmuJ_001127100 {ECO:0000313|EMBL:CDS43505.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43505.1};
RN [1] {ECO:0000313|EMBL:CDS43505.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43505.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902848; CDS43505.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YG58; -.
DR STRING; 6211.A0A068YG58; -.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG3528; Eukaryota.
DR OMA; ISARCTH; -.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR24135:SF28; LD13733P; 1.
DR PANTHER; PTHR24135; SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00248; ANK; 7.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}.
FT REPEAT 285..317
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 385..417
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 592..686
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 146..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 819..868
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 715..746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1046 AA; 115460 MW; 00BD6C636613DE07 CRC64;
MEMSRLSTST RYFSNPCDIQ LLHRIARSFP SVDRQHVPAG ALTNGISSLR SSTASSIASS
VTIQVPLPTP QSVHIGVKCP VTGVENIFVV QSTESVGHLR RHAVLRSDLD VEEALNYGLY
LPPQGSKKGK FLEDERPIAD YPVLLQSGGH RSRNAEDTSS VSSTTTTTTT TLTNGLHHSP
DSGVGQDPCW LELIYKSRMD TEDSPHQSRI RKLKTKVTQS HFMDMVRNQD VKGIEKLLAK
GFDPNFWSRK DGEAPITAAA TTYHPRDLII TLVNGGAHID FRARDSHTAL HRAAICGNYE
AIQTLLDLGQ NPNCRDWRGL TPLYYAVSTD ISARCTHALL YDHAILGVED SKGFQEIHQA
CVANRPQHLE NLVAYGADLN ARTLRGLTPL HLCVRHEANA CLSLLLLRGA DTRQVNDDSQ
TPLEYALLTN RNEQATILQT FNPADVVTIK ETPSYNTSRR PTVNGPRGAV IYTMLHRPST
SCSISDNLSL CHGVPSPAES LFSADQTSVT SFSAASTASA TLLESSRSMQ NIHRYANEDT
ASNPLKQLQQ LVEAPQTKRS NTYNDPKRKT SVPIRTCIPS SETREEKTYT RFVGLRKSHE
GFGFTLNGVP RKALQRHGRQ PLPNTPSNQY FSSVVPGGPA DRAGVKEGDY VLEIDGQDVT
DACHEDTVEC IRKCGDSLIL RVMTVYKDST LRHLCERPEM PQTSRTYRRR RQSDIIGGSS
SSNSFNSDSG FAAHTSSSTS TTIYKKKLPV SRDGEQRWRE PVGLEVRSRS RERGTYNPEV
RVQSYSFGEE DIHLHAISPA AHSKERVFVF KKIDGKTRAV PVEDPREQKS DLQNGSAARF
AGNRSASPSG AQRRRSPSSS SDTGSGHLSH AHSMMVVDCF DDGGEASTTA CSTNRDTTYK
NSLPRQVMQP FRSSLSVGCL QRINPSRGIG NDDEGEDDND DGENNRSGGT TAIQKYATSK
RPIKSEHSRS LPRLELLSLG CEQIEFVSAF PMQIYHHHDR PEEALYDSAY IPPSPQLMSF
LKPIRVTSFT LHVSVLCPGF VGKKFG
//
