ID A0A068YGD0_ECHMU Unreviewed; 2195 AA.
AC A0A068YGD0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN ORFNames=EmuJ_001009800 {ECO:0000313|EMBL:CDS42389.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS42389.1};
RN [1] {ECO:0000313|EMBL:CDS42389.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS42389.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902842; CDS42389.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YGD0; -.
DR eggNOG; KOG0951; Eukaryota.
DR OMA; QTEIQYY; -.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18019; DEXHc_Brr2_1; 1.
DR CDD; cd18021; DEXHc_Brr2_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Ribonucleoprotein {ECO:0000313|EMBL:CDS42389.1}.
FT DOMAIN 493..691
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 725..919
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1355..1544
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 182..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..233
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2195 AA; 248109 MW; F5701F0CAA046725 CRC64;
MADQAARSLQ FEYNINSNLV MTADRSLIDR RSRDESTGEV LSLAGKIRIE DMGSKAQRTR
PSMLEEKKAK RRKLEEEEYD EMRLKAVTLL SDDLDEVVGV LYRPKTPETR KTYEYILHCI
QEALGDQSRE ILCGAADEVL AALKNNKLRD KERRKEVESL IGPLADERYN IIVSLGKKIT
DWKDDNDETG EENIDEAYGV NVQFEESDQE DEDDTQYEIK DDDDDDIDGE EAGEEMTLQS
KATDEVSGSK SDVDTLHPRD IDAFWLQRNV SKHCKDPILA QRKAQECLDI LKTATDDRDL
ENRLVRCIGY EQFDFLRVLR RYPSMILYCT LLAQAQSPQE RAEVETKMRS DLKLSLILKQ
LRETNAPSDN VADERNRKAN QRVTRLRESS KGDGDGSNGS SDDGRGLVAN VVDLANLTFT
QGGHLMANKR CQLPEGSFRT QKKGYEEVHV PALRSKPFDQ DETLLKIEKL PAYAKAAFDG
LKTLNRIQTR LYNAAMKTDE NLLLCAPTGA GKTNVALLCI MHEIGHHISA DGSINKENFK
IIYIAPMRSL VQEMVGTFNK RLSSYGIKVD ELTGDHQLSR EQILETQVIV CTPEKWDVVT
RRGGDERAYI NLVRLIIFDE VHLLHDDRGP ILEAIVARTL RATEASAASG ISVSGAAVAS
PDTIRLVGLS ATLPNYTDVA TFLRVDVEKG LFYFDNSFRP VPLEQQYIGM TEKKAVKRFQ
LMNEIVYDKV VEHAGRNQIL VFVHSRKETG KTARAVRDMC LEKDTLGLFM KDKNASTMVL
RQEAEQVKNS ELKDLLPYGF AMHHAGMSRV DRTLVEDLFA DRHIQVLVST ATLAWGVNLP
AHTVIIKGTQ VYNPEKGKWT ELGPLDVMQM LGRAGRPQYD TKGEGILITN HTELQYYLSL
MNQQLPIESQ LVSRLPDLLN AEIVLGTVSN LRDAVNWLGY TYLYIRMLRA PSLYGVPTGS
EHTDPWLEQR RRDLIHTAAI ALERCGLINY ERRTGNFEST ELGRIASHFY LTHETVQTYN
KLLRPGLGEI ELFRVFAASS EFKHITVRQE EKFELAQLLE RVPIPIKEAA DDSSAKVNCL
LQAYISGLKL EGFSLVSDMV FITQSAGRLM RALFEIVLHK GWAELADNAL VLAKMIERRM
WESMCPLRQF KKLPDEVITK LEKKALPFER LYDMNHHELG ELVRSAKLGK PLHKYLHQLP
RLEMSVHVQP VTRSVLRVEL TLTPDFVWDE KTHGNTQAFW IFVEDVDGDT ILHREFFLLK
QRYATEEHVL HFTVPIFDPL PPHYYIRAVS DRWIGGEVTL PVSFRHLILP EKTVPPTELL
DLQPLPVTAL RNKEFEALYA DQIRDFNPIQ TQVFNSLYNS DENVFIAAPT GSGKTVCAEL
ALFRLMTTAQ ANQQVDESGE PVFKCVYVTP FEEQAELRFS DWSSRFATKL GRRVVRLTGE
TSVDLKLLAR GQIIVTTPGH WDVLSRRWKQ RKHVQGVNLF IADDLHLVGA EGGPVYEVVC
SRMRYMASQI ESSGQPLRIV GLAHSVTNLR DMASWLGCSA GASYNFQPNT RPLPLDLSIV
ELNFAHQASR LMAANRPMFR AINRHACLST GCGPGLHRPT IVFVTSRRQA QRTALDLITM
QATANTLGST QQQQLPKFVP LSGHLEEALE KAASQISDNA LSEILRYGGG VAYLHKALNK
GDRRLVEALY AAGALHTLVV SRDLAWASSI SAYLVIVLDT QDYNGKIHAY EDYPIIDMIQ
MVGRANRPGL DSDSKAIVFC QTGKREYLKK FLHDPLPVES HLDHELHDHF NAEIVTKTIE
NKQDAVDYLT WTFLYRRMTQ NPNYYNLQGV THRHLSDHLS ELVETTLTDL EQSKCIAIED
EMDLSPLNLG MIAAYYYIYH STIELFSLSL TNKMKIRGLL DVISNASEFD TLLPVRHHED
VVLRQLATKV PQKLAPKASY TSPHVKANLL LQAHLSRISL STELQGDTDK LLVCTVRLIQ
ACVDVLSSNS WLGPALAAME FSQMITQAVW HKDSYLRQLP HFNTERISKC KEAGVESIFD
LMELEDSARA QLLEGLSQAE VADVARFCNR YPDVEVNYEL TGPNGPITSK TQVKSGDTIS
VNVSVERDEA NAGPVLAPFF PQKREEAWWL VIGEVKTNSL IAIKRLTLAK SIKVRLELTV
PASAQGGGKH EYTLFFMSDA YMGCDQEYRF TLDVR
//
