ID A0A068YJE0_ECHMU Unreviewed; 2907 AA.
AC A0A068YJE0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 28-JUN-2023, entry version 44.
DE SubName: Full=Fetal alzheimer antigen falz {ECO:0000313|EMBL:CDS43399.1};
GN ORFNames=EmuJ_001115900 {ECO:0000313|EMBL:CDS43399.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43399.1};
RN [1] {ECO:0000313|EMBL:CDS43399.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43399.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LN902848; CDS43399.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YJE0; -.
DR eggNOG; KOG1473; Eukaryota.
DR eggNOG; KOG1632; Eukaryota.
DR OMA; FEDFCTA; -.
DR GO; GO:0016589; C:NURF complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd15560; PHD2_3_BPTF; 2.
DR CDD; cd15532; PHD2_CHD_II; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 3.
DR InterPro; IPR038028; BPTF.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018501; DDT_dom.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45975; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR PANTHER; PTHR45975:SF2; NUCLEOSOME-REMODELING FACTOR SUBUNIT BPTF; 1.
DR Pfam; PF02791; DDT; 1.
DR Pfam; PF00628; PHD; 3.
DR SMART; SM00571; DDT; 1.
DR SMART; SM00249; PHD; 3.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 3.
DR PROSITE; PS50827; DDT; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 280..340
FT /note="DDT"
FT /evidence="ECO:0000259|PROSITE:PS50827"
FT DOMAIN 472..519
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 2687..2755
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 65..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1270..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2046..2082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2105..2146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2215..2238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2294..2332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2402..2629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1208..1242
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1767..1843
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 65..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1323..1347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1365..1383
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1417..1446
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2218..2238
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2294..2331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2409..2423
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2428..2452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2488..2507
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2520..2546
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2576..2594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2598..2629
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2907 AA; 318718 MW; 08E14A33417CBFBC CRC64;
MGDSVNHPEG ISAPREGGHC QGPKKRPRLT FINPSEWVDL QPRCSVSTKK DADRNLCQRL
IDRQSKAKQE GVMRERLEFE ESKPKKRQKQ QKSRRGRPRK RPIDPKRPWI ESDDEEGDYV
VPVDDESDDD AFLQRLAEEK EREEAEEIKK KQELQRQRRL KREERRSRAT GRPGRPRTQI
LFAHLYANSN DDAQSSSKPS ETSDGEQSPL NDYAVEEEVL DFPPPPAMEN DNFDEVGNGV
GTNLESTSVP DFPQISPVVL RRRAPPLTLP PSSQDLICPL EHLLDALSIY QTLRRYGRLL
RLSPFQLEDF LSALLANENS NLIAAVHITL LNALITEDEA NGTHLCPPDC KDGVSLLSFI
IDRYTWPYFL SLYLSSVKRG ESAALAALAR VGNTATVASS GPIAAVTFSG GADAVVTSAL
FYPEDSVIPL DFSYPFVDLP QRLAVLRGLV GLFLATGPVR ADILREGFIA HDDFCRICRQ
SGEVLCCDTC PAVFHLTCLT PPLEAVPNSS WHCPLCETEQ EVYGERKVPK ARGETRISPL
GYDRAGRVYW YMEGRLFVEP VDFAQCEPEL PGLSEGARDE EWERREAEQP TGDDDEEGAG
EGGEKIECGV DGACDPSVAY ANEPPVYYYS SLECITSVRQ RLSTQWEPAL CVQLDTVIAL
MEAKEQKSKQ AAMKSEPKEC ESTKQENDCG EEKAEATESV VDVKKEEQDG DATELTKWPP
VLPLPSALTA AQLTALFSNS QSLHHIGSGG ETASSPMENA FVLELSGGVL VHNQDGLFEN
FPLPPDVHVQ RLSEPRPALV HSPLSSSVHL APSKRWRSWT NTLSQGLFVP NPTAETAELA
EVNIALNRPQ QHDEREKRRL LVNKFCLSDA ALEAWRWLDA EASAEMIRRA IGEESLDSAA
EADLVNRRAD AVGPLRWLHT MKLTLCFMEA QLPAAALCPV WRLLRKDWIA AVLKATSVHE
LADLLARLEA AIRPVAFQRT WTSSIGALQL DRFTSAQREE EKRMRALERS SAAVNAAPIT
LVRTKTIQPI RHTVWKTRGE EYRRLGGDGW QWVSATRRHQ KYLKTVTLQS AKPNIDRPAH
LGLGWGVKPE LLANADLHPP LPEDAALDYR VHPITGVPLC QNVSRSVYTI PPEALRNQPD
GVINISQCLR IGGGDFFPPP ARSPLPLSPT SKTHQCGRAH FRLDSLLAMR EAAALRDQAA
SEVARGDLDQ LRMERETMAA RVADIQSRLS ELSSEAQIAR TEHARAVKSR QTAITEMKQL
SEQRLNQSCY QGTIPSTPSL RDGGGGGGGG HAKSRASMTP GRNRSAASRR LQREEYNYDS
GESAESEESA ATSSSRPASS TTESNVLRRS SRRQKTKSVD PDFVVDFGED EEEEEEEGRV
DIDRDDEDFS LRQRGSDDEA IDGSSWAQGG GSVPQLDGAE DDDEDDIPEE DEGDEDEEDY
GVDENGTEND PEGKVDGLAQ KSTLRVAATG TVSTTVSGKG ALIPPSSSPG KSLLALAIEG
KAPGIVQIKQ STSNGESSAE AKVVGSGVGS GSGVTVVPTP IPTAPGGQPV RLVRVLRAPP
GAPAGTQIIQ AVDPPSAPTG ASGTGNLIIP ASTEPALQKS LIQLSSSGGV IVTQASTLPA
GYRLITPSSL PLTTTNTVSS MTSGGGASVV TSASRTPLNF VQVVSTTPSS SSVQGLRPRP
LVPQPLRAGQ PVTVSATGAP SLISIAPSPV VRAPPLRPLL APASRPILAS SPNLAPSLRP
RMVRVVTQPM QLDPSLDQAV TEAATKLHQV DLEIFNLRKE LRHLESQLAE LSARVEEKEA
MVARCGRSTA NPYSLSNHTT SLLARLNRAA KAATAANQRL KGRRFLTLPK HLPSVNPYAW
PPDKLFGSSV STYPEVDKDT PVPVPNLFRL SRVNLRALIL AAGRKEVPGY EAEKKRLASI
PWSYPTARPC FAEAWRFRLR QILLQPVASS CGILNTPSHY GVAMATLAAH LRLLWHSLRW
DEIMLTAAAC EDATLMADRY YLKQSISDGH GGGFALRRVV AIKPLDKYWL RANFLVETSV
QKPAASKRFA RGNSRASLGG NSDASTSRRS GRGSKRFADP DYDPAADEGW RVGIPCSNRR
RRRTNYNEDR LMEEDEAGED VKTNEDQGVE DQGDSSSSRR DAKKTEEWVS EEALQLWEIR
NFFDSLLPID SDYPPPLGPL ALTGLPAGLV EEASSIAKEE EMECRGSWIQ PARCPSPEAF
KPASPKPPSP PPPLPPPPSV VVMETPKPIV VSQPRPSVTP TAPVISQPAF RPLIINSNRP
QAIRTSLMAT SRQHVPPPVQ LTQSSGIAAT TTVPCSTPRR TGGSTAAPLS PNSEAARARA
RSLAASHAAR ISAANRRFRT EKAALDTRVA SLVEELANRR RLSVKYMALQ VQEEILQAKK
ATQREALTDP TPPAPPPPLP PLKLKVQTSE RLSASAGRGE SKSTAATTSK TRTTRAGRKR
RIARQQLLHT HPSTPPTAPA TDSDEDHYAM TSQSRQTKRR KVGELKNEAP PYIKTEAPTP
RIRRGGRPSK DIGSPTNGKR RRFEEFTTPF SPTAKVATAT TRSSRGKARG RGGRGASKST
PSTLSNSAVS RTRLSIRTPR YLLEEAEREK AGTRSRRRSN DDDGDAAERS YKVEKADDFD
DKRIYCLCRK PYDPSQAYIG CDLCQDWFHF TCVGLESGTS TAALGDSWLC PECQRAEDKA
KDEVYCLCRT PYDPTRVYIA CDRCDEWYHA ECVGLEAEAV SKHEGEYICP MCTKRADNVL
KGNEDFKGGD SYDKKVKKEE PDETQKTLYE APLTEPVKGA VLELFDDLEA HKLSWPFMKP
LPQSDQQNLP SPMKGPTDLA SFRAAFDRGV YRSLGDISFA GNHLFSNARL VFDAASTEFH
CVEVLEAFFL RRMKEVRSLS QQDSPFS
//
