ID   A0A068YM54_ECHMU        Unreviewed;       994 AA.
AC   A0A068YM54;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   22-FEB-2023, entry version 31.
DE   SubName: Full=RhoGAP {ECO:0000313|EMBL:CDS43268.1};
GN   ORFNames=EmuJ_001101200 {ECO:0000313|EMBL:CDS43268.1};
OS   Echinococcus multilocularis (Fox tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX   NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43268.1};
RN   [1] {ECO:0000313|EMBL:CDS43268.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23485966; DOI=10.1038/nature12031;
RA   Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA   Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA   Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA   De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA   Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA   Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA   Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA   Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA   Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA   Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA   Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA   Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA   Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT   "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL   Nature 496:57-63(2013).
RN   [2] {ECO:0000313|EMBL:CDS43268.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhang Y., Guo Z.;
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the FAM13 family.
CC       {ECO:0000256|ARBA:ARBA00007549}.
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DR   EMBL; LN902844; CDS43268.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A068YM54; -.
DR   STRING; 6211.A0A068YM54; -.
DR   eggNOG; KOG4270; Eukaryota.
DR   OMA; HTQNNHT; -.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR039102; FAM13.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   PANTHER; PTHR15904; FAM13; 1.
DR   PANTHER; PTHR15904:SF17; RHO-GAP DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   3: Inferred from homology;
FT   DOMAIN          27..217
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          486..521
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   994 AA;  110942 MW;  AF5613DCDE8D4512 CRC64;
     MERIVQKLNS PLLKRKSLAD GNRSFGVPLK SLFYKKSSSV PRIVENICEF LLNFGSHTEG
     IFRVNGSAKA IANLKAQFDA TCADDISNTG CVDIHAICGV FKLFLREIPE GLIPDTATRQ
     TVKIMDHLKD DKPQCLLKLR NVVTNLPEEN YNLLRYICHF LEELASNEAS TKMSAANLGI
     VFGPCLFKCG LGVQGLRQQN LSNLATTCFI THFGTIFSPA TSVNSSVQQF GLLKSAASLN
     SLLQRRRHDV PRRSIAPAAS TEEAMAEGVE GGLRSRTISP WGDSASPLLS VPVGNSSNIA
     SHSTNSLLLS PSRKWLYSDA EEIEIRSHGA LARELASIMT SISIPSVTKL NQLSDAAPTS
     NTIFTTVAVP SSKSTSEKEE DKVEVRRSPP SLPSLVHLYH HNQHHHPHHR HKYHVWRGQC
     EELEGKEKIS SDSSSTTSLL EVAAALTFSQ LLMESTTETT THTLTVEEFE PAHAYLSSSI
     VDDMHSACPT SDAEEKDQAD EEDVEETREN SSATTSSTHH FPRAKCRLPH VFSAPKQHRN
     SSCRLHHGVL NYLDYLSADA AFGEFRVLPS AEAIVCSIHP SDDYIPPLQP ILPPRILIAN
     PVCQSITPRP RHILTWPRKR NILSRLRNRR SLDVYIPLTG RPNGDETTTF SNASKERSVE
     PSSSLDISLP DPIHLEVAGF LTVLQAVLET RRKECRRPED VEHMSSAELA QEKLDLQKCL
     LYFEKMKGRP SDPITKRVMK PIYDRYRCVR RMVRLASNSA IRFSRGRSSG SAPRPFVDSV
     RTLMGIAVVE PTQTDEVVKF AETEPIITLE PPLTPEALLG TSSTNFSQTE TDQTASLMSN
     GAESLPSFFL NWELTLLEFI QFAMNVDPGE LTRGRAEILS VKHKLQRFLH DYEKRIQEVT
     NHPPSKRDRD GLRSEYNRYR DCKQRLYVID RFVEEPQTNL ESLIVDAQSV GRAHRRRKVV
     ESAVGKDETI QQKVSTTIKT ATPMLKSQDS ASYT
//