ID A0A068YM77_ECHMU Unreviewed; 1477 AA.
AC A0A068YM77;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Unc 13 (Munc13) {ECO:0000313|EMBL:CDS43288.1};
GN ORFNames=EmuJ_001103400 {ECO:0000313|EMBL:CDS43288.1};
OS Echinococcus multilocularis (Fox tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Echinococcus.
OX NCBI_TaxID=6211 {ECO:0000313|EMBL:CDS43288.1};
RN [1] {ECO:0000313|EMBL:CDS43288.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23485966; DOI=10.1038/nature12031;
RA Tsai I.J., Zarowiecki M., Holroyd N., Garciarrubio A., Sanchez-Flores A.,
RA Brooks K.L., Tracey A., Bobes R.J., Fragoso G., Sciutto E., Aslett M.,
RA Beasley H., Bennett H.M., Cai J., Camicia F., Clark R., Cucher M.,
RA De Silva N., Day T.A., Deplazes P., Estrada K., Fernandez C., Holland P.W.,
RA Hou J., Hu S., Huckvale T., Hung S.S., Kamenetzky L., Keane J.A., Kiss F.,
RA Koziol U., Lambert O., Liu K., Luo X., Luo Y., Macchiaroli N., Nichol S.,
RA Paps J., Parkinson J., Pouchkina-Stantcheva N., Riddiford N., Rosenzvit M.,
RA Salinas G., Wasmuth J.D., Zamanian M., Zheng Y., Cai X., Soberon X.,
RA Olson P.D., Laclette J.P., Brehm K., Berriman M., Garciarrubio A.,
RA Bobes R.J., Fragoso G., Sanchez-Flores A., Estrada K., Cevallos M.A.,
RA Morett E., Gonzalez V., Portillo T., Ochoa-Leyva A., Jose M.V., Sciutto E.,
RA Landa A., Jimenez L., Valdes V., Carrero J.C., Larralde C.,
RA Morales-Montor J., Limon-Lason J., Soberon X., Laclette J.P.;
RT "The genomes of four tapeworm species reveal adaptations to parasitism.";
RL Nature 496:57-63(2013).
RN [2] {ECO:0000313|EMBL:CDS43288.1}
RP NUCLEOTIDE SEQUENCE.
RA Zhang Y., Guo Z.;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LN902850; CDS43288.1; -; Genomic_DNA.
DR STRING; 6211.A0A068YM77; -.
DR eggNOG; KOG1011; Eukaryota.
DR OMA; RIKVRIW; -.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd04027; C2B_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF12; UNC-13, ISOFORM E; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF06292; MUN; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 264..314
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 373..497
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 884..1007
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1115..1280
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1296..1427
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..60
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..100
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1477 AA; 166135 MW; 01A2F4D50BEF717E CRC64;
MGEKERNREE ESIQSGTSSV SDSGKAEIEK EDRGEEEEEE DDDEGEEDEE EEEEDEMTPD
EAFNLATADS SSEDFLQTGA LVVEEDTPPP PPPSASPPPL VISPAHTLTS PQASMAKKED
EEGEEESKGQ VKAKDEVAEG SGSQSPPPQI DRHMRARWRW ALLSQNRDLM FSQDNSDEKS
QIFNRAAKSF YQSIDSAPER RWSKRTLPLV SDLVLQTMSA QKRTASVLPA SIGQSTTLNG
ADLKLLVYRK TLNALAYPIS GNTPHNFEMF NATSPTYCYE CEGLLWGVAR QGLRCSECGV
KCHEKCKRLL NADCLQRSAE KSSRHGAEDK AQAAMNSMRS LIHRRLADRP DIFRAIFDIF
AIDPVEGRAR AERLAEVERS ILSGASQWSA KLAITVKSAQ GLIGKDKSGR SDPYVTVQVG
KVRRRTKTVP QELNPTWDEK FWFECHNASD RIKVRIWDED NDLKSKIRQK FTRESDDFLG
QAIIEVRTLG GEMDLWYNLE KRTDKSAVSG AIRLNISIEI KGEENSAPYH IQYTCLHECL
FNYLCAKNPP VYLPSQAPKR KSVTEELWRV FFDPLGQEIS DEFAMRYGIE SIFQAMTHFA
CLTTKYNCVG VPAQLSTLLA NINAFYAHTS SNNSQTASER FAASNFGREK FVKILDNLHN
ALRIDLSKYR TIFPASQPER LVDMKCTVDV LTSITFFRLK VQELAAPPRT LQVLRECIRA
CMKATYECLS DNVQALYGGN FQNDSAHTSA LSSSEKSSAE SQSDIDPVLG VRSLSYWHKL
ISLMVSVIED DRKHYAPVLN QFPQDINLGD LSAEMMWNLL AEDISVGLTQ HYEAVLRRLT
DTTPTITTSS RQKRSTAVAT VEQTGEQITT TRLSKAKIKT SDYLNLCFRI KWFYNTYVRP
SRRNRKEDDP EYPKWFEPLV MLWLSENDEV SENYLRNAYE RDKRDGFQRS SEHALYSNSV
VDVFTQLNQC FDVIRKLECP DRDVEANYMH RFAQTVEKVL LAYSESVQLD FAQFKSDART
ACILINNTQQ LRVQLEKVYE AMEGEDFNLH EETRKQLTKL QVCLKNAVDL LVFAFAGEFE
EDIQRSVLEM GRLLQGCKET TSGGGSAEGM EADCENCLRP LMDYFELVLS AQASSCEKTV
LKRLLKELWR ITMENTEKLV VLPGVSDTKQ ALPTVLVGPK GTASAKLIGG AQSLLSHVGQ
NVSAAKILQD FAGESLVGSR GLTPYQCEVL TNCLETVQVY FHAGGRGLKR SFLQSSPELH
NLQQALALYS QTTDTLLKDY VTTEIFIMDT ISPDDACGYL NVQVEVFKHP GTGEYKAIVK
VLSASDLSGV MVSGLFRPFV EVYLFGPLLT DCKRRFTTKS KSGTISPLFN ETFVYYLSSR
SDPEWYELQF VVKDYCFGRS DRLVASSLLT LSQALDLGGS APVRLPLTRR QTQSEAGWTV
LRILSQRLAT DEVAREFVRV KTECCSAAAT STVIQAE
//
