ID A0A068YZ16_9BURK Unreviewed; 507 AA.
AC A0A068YZ16;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase / Enoyl CoA hydratase {ECO:0000313|EMBL:CDS55236.1};
DE EC=1.1.1.35 {ECO:0000313|EMBL:CDS55236.1};
DE EC=4.2.1.17 {ECO:0000313|EMBL:CDS55236.1};
OS Polaromonas sp. CG9_12.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Polaromonas.
OX NCBI_TaxID=1504672 {ECO:0000313|EMBL:CDS55236.1, ECO:0000313|Proteomes:UP000043372};
RN [1] {ECO:0000313|EMBL:CDS55236.1, ECO:0000313|Proteomes:UP000043372}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Smith H.J., Foreman C.M., Ramaraj T.;
RT "Draft Genome Sequence of a Metabolically Diverse Antarctic Supraglacial
RT Stream Organism, Polaromonas sp. Strain CG9_12, Determined Using Pacific
RT Biosciences Single-Molecule Real-Time Sequencing Technology.";
RL Genome Announc. 2:1-2(2014).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CCJP01000005; CDS55236.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068YZ16; -.
DR STRING; 1504672.gene:199034503; -.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 5287258at2; -.
DR Proteomes; UP000043372; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:CDS55236.1};
KW Oxidoreductase {ECO:0000313|EMBL:CDS55236.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000043372}.
FT DOMAIN 8..186
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 189..286
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 416..495
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 507 AA; 54632 MW; C580EC46B4A24748 CRC64;
MQATFYQTVG IVGTGAMGRG IAQIAAQAGS TVKLMDAQAG AAAKAREALC SQWDRMREKG
RIGADIADAH KARVQVADTL DDLSSCDLVI EAIVERLDAK KALFAQLEAI VPERTVLASN
TSSLSITAIA AGLTHPSRFA GYHFFNPVPL MKVVEVIAGL KTSTDTCQGL SEYARQTGHT
PVQAQDTPGF IVNHAGRGYG TEALRIVSEG IADFATIDRI LRDQAGFKLG PFELMDLTAL
DVSHPVMESI YHQYYEEDRY RPSVITAQRL AGGLLGRKTG EGFYRYDGGM AQIPAEAPVP
DVAEMPPVWV SPRAARRSEL LQLLKNLGAH IETGPSPSPQ ALTLVAPLGF DITTVAVVER
LDPARTVGID MLIDDAAIKR RVLATNPATR SDMRDAAHAL FARDGKAVSV IRDSGGFVTQ
RVVATIVNIA SDICQQGICS PKDLETAVTL GLGYPMGPLA MGDRYGPTNV LEVLFNLQTV
YGDQRYRPSP WLRRRGAIGL SLMHEEH
//
