ID A0A068ZC65_9GAMM Unreviewed; 339 AA.
AC A0A068ZC65;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN ORFNames=SYMBAF_11170 {ECO:0000313|EMBL:QLH63386.1};
OS Serratia symbiotica.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Serratia.
OX NCBI_TaxID=138074 {ECO:0000313|EMBL:QLH63386.1, ECO:0000313|Proteomes:UP000042738};
RN [1] {ECO:0000313|EMBL:QLH63386.1, ECO:0000313|Proteomes:UP000042738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWBI-2.3 {ECO:0000313|EMBL:QLH63386.1};
RX PubMed=25146134;
RA Foray V., Grigorescu A.S., Sabri A., Haubruge E., Lognay G., Francis F.,
RA Fauconnier M.L., Hance T., Thonart P.;
RT "Whole-Genome Sequence of Serratia symbiotica Strain CWBI-2.3T, a Free-
RT Living Symbiont of the Black Bean Aphid Aphis fabae.";
RL Genome Announc. 2:e00767-e00714(2014).
CC -!- FUNCTION: Efflux system for nickel and cobalt.
CC {ECO:0000256|ARBA:ARBA00002510}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362101};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362101}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family. RcnA
CC subfamily. {ECO:0000256|ARBA:ARBA00010428}.
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DR EMBL; CP050855; QLH63386.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A068ZC65; -.
DR STRING; 138074.SYMBAF_80071; -.
DR Proteomes; UP000042738; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006824; P:cobalt ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR PANTHER; PTHR40659; NICKEL/COBALT EFFLUX SYSTEM RCNA; 1.
DR PANTHER; PTHR40659:SF1; NICKEL_COBALT EFFLUX SYSTEM RCNA; 1.
DR Pfam; PF03824; NicO; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Cobalt transport {ECO:0000256|ARBA:ARBA00022426};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362101};
KW Nickel {ECO:0000256|ARBA:ARBA00022596};
KW Nickel transport {ECO:0000256|ARBA:ARBA00023112};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362101};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362101}.
FT TRANSMEM 74..103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 155..172
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 254..280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
FT TRANSMEM 301..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362101"
SQ SEQUENCE 339 AA; 37294 MW; 85EAB425B135EE1F CRC64;
MSINLSQPSG HKHHWIFSLW PLLLFALLLT LAAQLAWHFW PQLLMHAVIW QKALHQQMAG
LLQQVKAAPH QVGWLLMLFS LSYGVLHALG PGHGKVVIAT YLATHPVRLK SSLKLTFAAS
LVQGLVAIAL VTLMLEVLQL SSRQLHYSSF WLEKGSFILV MLFGALLSWR ALKRLYSVLK
AQRLAPALRI SHLEPLAANH MHSEHCGCGH RHLPSDSELL GSDWRTQAAI VLVMGMRPCS
GAILVLLFSK LIGVFIWGVI SALAMALGTS LSISLLALLV HYSRQLAMHL SRSRAPAAWH
AVAWAALALA GGLMLVFVGL LLYVSVQPEF GGSIRPFSR
//
