UniProt: A0A069CTS9

Database: UniProt
Entry: A0A069CTS9_WEIOS

LinkDB:  A0A069CTS9_WEIOS 
Original site:  A0A069CTS9_WEIOS

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Ontology (5)   
   GO (5)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (11)   
   InterPro (6)   
   Pfam (3)   
   PROSITE (1)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (19)   

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ID   A0A069CTS9_WEIOS        Unreviewed;       670 AA.
AC   A0A069CTS9;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Cyclic-di-AMP phosphodiesterase {ECO:0000256|PIRNR:PIRNR026583};
DE            EC=3.1.4.- {ECO:0000256|PIRNR:PIRNR026583};
GN   ORFNames=WOSG25_060120 {ECO:0000313|EMBL:GAK30894.1};
OS   Weissella oryzae (strain DSM 25784 / JCM 18191 / LMG 30913 / SG25).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae; Weissella.
OX   NCBI_TaxID=1329250 {ECO:0000313|EMBL:GAK30894.1, ECO:0000313|Proteomes:UP000030643};
RN   [1] {ECO:0000313|Proteomes:UP000030643}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 25784 / JCM 18191 / LMG 30913 / SG25
RC   {ECO:0000313|Proteomes:UP000030643};
RX   PubMed=25013139; DOI=10.1128/genomea.00667-14;
RA   Tanizawa Y., Fujisawa T., Mochizuki T., Kaminuma E., Suzuki Y.,
RA   Nakamura Y., Tohno M.;
RT   "Draft genome sequence of Weissella oryzae SG25T, isolated from fermented
RT   rice grains.";
RL   Genome Announc. 2:0-0(2014).
CC   -!- FUNCTION: Has phosphodiesterase (PDE) activity against cyclic-di-AMP
CC       (c-di-AMP). {ECO:0000256|PIRNR:PIRNR026583}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',3'-c-di-AMP + H2O = 5'-O-phosphonoadenylyl-(3'->5')-
CC         adenosine + H(+); Xref=Rhea:RHEA:54420, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:71500, ChEBI:CHEBI:138171;
CC         Evidence={ECO:0000256|PIRNR:PIRNR026583};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm
CC       {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the GdpP/PdeA phosphodiesterase family.
CC       {ECO:0000256|PIRNR:PIRNR026583}.
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DR   EMBL; DF820489; GAK30894.1; -; Genomic_DNA.
DR   RefSeq; WP_027698955.1; NZ_DF820489.1.
DR   AlphaFoldDB; A0A069CTS9; -.
DR   STRING; 1329250.WOSG25_060120; -.
DR   eggNOG; COG3887; Bacteria.
DR   OrthoDB; 9759476at2; -.
DR   Proteomes; UP000030643; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0106409; F:cyclic-di-AMP phosphodiesterase activity; IEA:RHEA.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.310.30; -; 1.
DR   Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001667; DDH_dom.
DR   InterPro; IPR038763; DHH_sf.
DR   InterPro; IPR003156; DHHA1_dom.
DR   InterPro; IPR049553; GdpP-like_PAS.
DR   InterPro; IPR014528; GdpP/PdeA.
DR   InterPro; IPR000160; GGDEF_dom.
DR   PANTHER; PTHR47618; BIFUNCTIONAL OLIGORIBONUCLEASE AND PAP PHOSPHATASE NRNA; 1.
DR   PANTHER; PTHR47618:SF2; CYCLIC-DI-AMP PHOSPHODIESTERASE GDPP; 1.
DR   Pfam; PF01368; DHH; 1.
DR   Pfam; PF02272; DHHA1; 1.
DR   Pfam; PF21370; GdpP_PAS; 1.
DR   PIRSF; PIRSF026583; YybT; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|PIRNR:PIRNR026583}; Hydrolase {ECO:0000256|PIRNR:PIRNR026583};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR026583};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030643};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          184..312
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
SQ   SEQUENCE   670 AA;  74969 MW;  9F95BDD8B0CC2DF8 CRC64;
     MEGENSFSAV FHNKQLSGVA IIVSLMAVIG TVVAFLVHWI IGIIWVLLVI VALVVTFRTL
     RAIGEETTTY IRGLTTRINR AEQEAVVQMP IAVILYNNDN NVVEWVNPFI QGILADEIII
     NKELSEVNKN LAALVKNWYD EESRVTRLNW LHRVFDVQVQ PELGVIYLQD ATKSAQIQAN
     YETHRLFLGQ VSIDNYDEVT EGMSDADTSS LRSYVTRTLS DWMQERDIYV RRLTSVRYLL
     IGYRSGLRAA ENDKFNILNT IREMTSAQNT PLSLSIGIAY DEANITELAG NAQINLDLAL
     GRGGDQVVVR SEQGRARFYG GNTNPMVKRT RVRARMISQA LAELVRQADQ VFIIGHARPD
     MDSFGAALGI RRLAMMMDKP AWVVYKDTGK AHTDIKLLLN QIVNEQGDGV VLTPNEAMLR
     ATDHSLLVMV DHSKPSLSED RDFYDRLKDR LIIIDHHRRG EEFPESSLLT YIEPYASSTS
     ELVTELFEYQ PRRTKGLTRL EASALLAGIQ IDTKSFTLRA GTRTFDAASY LRSVGADGDM
     IQDFLKETVE DYRDRSHLIE QVQIHDRSAI VIGENNVNYD SVVTAQTADA LLQLIGVDAS
     YVITRRDNHT VGISARSTGA QNVQLVMEAM GGGGHLSNAA TQITDATTDE VYLQLVEAIR
     EIKAKNSNIE
//

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