ID A0A069I6M7_9BURK Unreviewed; 717 AA.
AC A0A069I6M7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KDP85153.1};
GN ORFNames=CF70_015415 {ECO:0000313|EMBL:KDP85153.1};
OS Cupriavidus sp. SK-3.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=1470558 {ECO:0000313|EMBL:KDP85153.1, ECO:0000313|Proteomes:UP000023560};
RN [1] {ECO:0000313|EMBL:KDP85153.1, ECO:0000313|Proteomes:UP000023560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK-3 {ECO:0000313|EMBL:KDP85153.1,
RC ECO:0000313|Proteomes:UP000023560};
RA Vilo C., Benedik M.J., Ilori M., Dong Q.;
RT "Cupriavidus sp. strain SK-3.";
RL Submitted (MAY-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: In the central section; belongs to the 3-hydroxyacyl-CoA
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00007005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KDP85153.1}.
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DR EMBL; JFJV02000228; KDP85153.1; -; Genomic_DNA.
DR RefSeq; WP_035870270.1; NZ_JFJV02000228.1.
DR AlphaFoldDB; A0A069I6M7; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000023560; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43612; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA; 1.
DR PANTHER; PTHR43612:SF3; TRIFUNCTIONAL ENZYME SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NAD {ECO:0000256|ARBA:ARBA00023027}.
FT DOMAIN 320..496
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 499..596
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 717 AA; 76449 MW; 76CDF514B4DC4291 CRC64;
MKPISVSVDQ DGIALITIDC ADRPVNVYTP ALTAGMSEAV EHVLANDAIV GAIITSGKDG
FLAGADLNAV LGRLEAALTQ GRSALPGFVA ENLFMRRMET GGKPFAAAIN GTALGGGLEL
CLACHYRVLS DAPNTRVGLP EVGVGLLPAG GGTQRLPRLL GIEAALPLLL DGTPLAPERA
LALGVVDEIA PCAELVMRAK RWLLANRGAR QPWDRDGYRL PGGAGALAEH ALRSFHTGIA
QVRSRTHGNY PAPLAILSAV YEGTQLPFDR GMAIEAQYFA QLAADPVARN LVRTQFVNRK
RYERLAHRPQ GIPQGAAQRL GILGAGMMGA GIAFAAARAG IEVVLLDATR EQAAAGRLRA
MEMATRAAVS TTQSEPTQHA GKLIHATAHY GDLDGCDFVI EAVFEDRAVK ADVIARALTV
LSPTAIFASN TSTLPITSLA TGTGRPERFI GMHFFSPVDR MPLLEIILGE RTSRETLAHA
MDLAARLRKT PIVVNDSPGF YTSRIFCAYV DEAMAMLAEG VKPALIENAA RMAGMAVSPL
AVLDEVSLDL QQRVVRQAEA DGVPEPLRRI HAQPVIARMN AIDRLGRKRG GGFYDYPEGG
RKHLWPGLAQ AYPAARQQPG LEEVKRRLLH VQALESVRCM EEGVISAPED ADIGAILGLG
FPAWTGGPLS LVDTIGVRAF VLACDALADA YGSRFRPTQA LRERARRGEP FYSKEAA
//