ID A0A072NVG9_9EURO Unreviewed; 547 AA.
AC A0A072NVG9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=VHS domain-containing protein {ECO:0000259|PROSITE:PS50179};
GN ORFNames=A1O9_12192 {ECO:0000313|EMBL:KEF51854.1};
OS Exophiala aquamarina CBS 119918.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF51854.1, ECO:0000313|Proteomes:UP000027920};
RN [1] {ECO:0000313|EMBL:KEF51854.1, ECO:0000313|Proteomes:UP000027920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF51854.1,
RC ECO:0000313|Proteomes:UP000027920};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Component of the ESCRT-0 complex composed of HSE1 and VPS27.
CC {ECO:0000256|ARBA:ARBA00011446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEF51854.1}.
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DR EMBL; AMGV01000021; KEF51854.1; -; Genomic_DNA.
DR RefSeq; XP_013254444.1; XM_013398990.1.
DR AlphaFoldDB; A0A072NVG9; -.
DR STRING; 1182545.A0A072NVG9; -.
DR GeneID; 25287086; -.
DR VEuPathDB; FungiDB:A1O9_12192; -.
DR HOGENOM; CLU_036827_0_0_1; -.
DR OrthoDB; 922060at2759; -.
DR Proteomes; UP000027920; Unassembled WGS sequence.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd14232; GAT_LSB5; 1.
DR CDD; cd16980; VHS_Lsb5; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR044103; GAT_LSB5.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR045007; LSB5.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47789; LAS SEVENTEEN-BINDING PROTEIN 5; 1.
DR PANTHER; PTHR47789:SF1; LAS SEVENTEEN-BINDING PROTEIN 5; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000027920}.
FT DOMAIN 133..255
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT REGION 243..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..495
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 547 AA; 61524 MW; 78E7FAFADFA960E6 CRC64;
MPPSLSLFLI HAPACTPDAG LVDLVQHDDN EKADLNELEH LLDAEDTPAE CHCCGRRKKR
RSFNAYPEQS YGPQVIPRRR PPPEIRGCKR LLISLLHIAC CYRSRRKFQL ITRYQYHKQK
KPFSAVSVHV EQLTSETYEE DDLAGVPELL EVIKLQATGS QEVARALRKK LKYGNAHRQL
RSLSILDGLL QNGGPRVQRA LLSDGPLLER LRIAAVDPLS DQDVRTKCKD LFGQWVASSK
DNPGLEGAKS LYNQLPKTQK PAHQRREQSR VLRETEEDVQ RERELEMSRD RSDSGPKMGE
PSSPPTSRKL QSPVTLGSSS TFSPKKVKKD KKNKVKGFNL EREKPQILQS IAASSVASTG
LNNALRLVNR EREQVSNNPE VMKRFETCKQ LRRQILRYIQ FVETEEFLGG LIHANEELVT
ALMAFEVMDK SVDDDSDSEM EEAQHLSRQA ARSEQAATRE AEKLVAGLSI SAPPKPPRPS
PPSHIAMPPP RPAAASPRNF KGRQAESESE TESEEDDDPD DPFGDKNAMK TPDPDSLGRK
GYTWKEV
//
