ID A0A072NX80_9EURO Unreviewed; 548 AA.
AC A0A072NX80;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=NCS1 family nucleobase:cation symporter-1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=A1O9_12273 {ECO:0000313|EMBL:KEF51638.1};
OS Exophiala aquamarina CBS 119918.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF51638.1, ECO:0000313|Proteomes:UP000027920};
RN [1] {ECO:0000313|EMBL:KEF51638.1, ECO:0000313|Proteomes:UP000027920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF51638.1,
RC ECO:0000313|Proteomes:UP000027920};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEF51638.1}.
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DR EMBL; AMGV01000022; KEF51638.1; -; Genomic_DNA.
DR RefSeq; XP_013254228.1; XM_013398774.1.
DR AlphaFoldDB; A0A072NX80; -.
DR GeneID; 25287167; -.
DR VEuPathDB; FungiDB:A1O9_12273; -.
DR HOGENOM; CLU_021555_4_1_1; -.
DR OrthoDB; 1218881at2759; -.
DR Proteomes; UP000027920; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd11482; SLC-NCS1sbd_NRT1-like; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR012681; NCS1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR NCBIfam; TIGR00800; ncs1; 1.
DR PANTHER; PTHR30618; NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER; 1.
DR PANTHER; PTHR30618:SF0; PURINE-URACIL PERMEASE NCS1; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000027920};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 446..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 548 AA; 61009 MW; 326C02987513B8A7 CRC64;
MSALRERVHH VHAEIKNKTT RDGWVLEKQD SSWAPAGTWS NADLDITPVD RRTWTSWTIF
GYWFSDIISI QSWQTGSTIL AVGLTWREAV FAIIFGSFVM GVPMALNGYT GAKTHAPFPI
LARASFGYHL AKFPVVVRLI TALFWHSITN FLGVGPTIQV IRAIWPSFRT LPNHLPESAG
ITSQQMIAYF VLWVVQFPLL MIPPHKMRWL FTVKIIMAMS TIVGMTIWIC VKAGGSGDIW
DQQPQVSGSA KSWLIMWSLN SCTASWSTVG VNIPDFTRYL HKPRSALQQA AWFPLICSWV
AVIGIVVTSA SYVLYSEYIW DPIAIIDTWD GAGGRAAAFF AGLSWVLAQI CVNVSATVIS
GANDLANLFP KWFNIRRGAI FITIIGGWAM VPWKILHSAS SLLSFMGSLA IFLSPMMAIQ
IADFFVIKKQ NLDLPALYQP QGRYRYVFGV NWRALFALGA SIVPCLPGLA YNVNPNVEIG
GAAYLIQFNW YYGFFVAFVC YIATSLLFPA NETLVPCMIE TNDQGGLESI EIEKGLSVVT
ANERQNDQ
//
