ID A0A072NZP2_9EURO Unreviewed; 753 AA.
AC A0A072NZP2;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=DNA mismatch repair protein MLH1 {ECO:0000313|EMBL:KEF52887.1};
GN ORFNames=A1O9_10792 {ECO:0000313|EMBL:KEF52887.1};
OS Exophiala aquamarina CBS 119918.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF52887.1, ECO:0000313|Proteomes:UP000027920};
RN [1] {ECO:0000313|EMBL:KEF52887.1, ECO:0000313|Proteomes:UP000027920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF52887.1,
RC ECO:0000313|Proteomes:UP000027920};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEF52887.1}.
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DR EMBL; AMGV01000015; KEF52887.1; -; Genomic_DNA.
DR RefSeq; XP_013255477.1; XM_013400023.1.
DR AlphaFoldDB; A0A072NZP2; -.
DR STRING; 1182545.A0A072NZP2; -.
DR GeneID; 25285696; -.
DR VEuPathDB; FungiDB:A1O9_10792; -.
DR HOGENOM; CLU_004131_2_0_1; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000027920; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000027920}.
FT DOMAIN 253..372
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 83733 MW; 9996F8A62AA3E74E CRC64;
MAEPMEVEPD GPRGIKRTAQ EAGLPPEAPR NRKADSSLKA LDQDVVNKIA AGEIIVAPMH
ALKEMLENSI DAGSTSIEIL VKDGGLKLLQ ITDNGHGIEK DDLPILCERF TTSKLKHFED
LLAIGTYGFR GEALASISHI AHLKVTTKTA NSSCAWQAHY AAGKLTPAKP GQSPDPKPCA
GRQGTQITVE DLFYSIPNRR RAFRSPSEEY AKVLDVIARY AVHREGVAFS VKKHGETSSA
FSVAAAATKM DRIRQAHGPG IAKELVEFTI EDSKWGFKAS GYSTNANYSV KRTTLLLFIN
NRSVESSAVK KAIEQTYQLF LPKGGHPFAY LSLDIEPTRV DVNVHPTKRE VHFLNEDEII
EVVCSEIRER LAKVDTSRMF KTQTLLPGVT PMTPMNPRPG ALADTPSSDG SIPRKQSTTK
KPYENNLIRT DSKMRKITSM LPLTFTPSTS IDDPSAPPDG LVYTATGREQ IQVRLSSVKK
LRTDVRESMH NGLTEVFASL TYVGLVDSNR RLAAVQSGVK LYLIDYGMAA NEFFYQVGLT
DFGNFGLIQL HPPPSLRELL EMAAQHYIDT EADCAELNKD HLVQRVYDQL MDRKQMILEY
FAIEISDEGN LESIPLLLKG YTPSLAKLPT FLLRLGPFVD WTQEEECFRT LLRELASFYV
PEQLPEPRPA SSSKVNPGDI DLETVSDEGQ DNHYTSSDNI HAAIEKRRKE ITYALEHVIF
PAFRSRILAT EPMLKGVVEV ANLKGLYRVF ERC
//
