ID A0A072PAG4_9EURO Unreviewed; 385 AA.
AC A0A072PAG4;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Sterol 24-C-methyltransferase {ECO:0000256|RuleBase:RU362025};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362025};
DE AltName: Full=Delta(24)-sterol C-methyltransferase {ECO:0000256|RuleBase:RU362025};
GN ORFNames=A1O9_11423 {ECO:0000313|EMBL:KEF52580.1};
OS Exophiala aquamarina CBS 119918.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF52580.1, ECO:0000313|Proteomes:UP000027920};
RN [1] {ECO:0000313|EMBL:KEF52580.1, ECO:0000313|Proteomes:UP000027920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF52580.1,
RC ECO:0000313|Proteomes:UP000027920};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the transfer of methyl groups from S-adenosyl-
CC methionine to the C-24 of sterols. {ECO:0000256|RuleBase:RU362025}.
CC -!- PATHWAY: Steroid metabolism. {ECO:0000256|RuleBase:RU362025}.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. Erg6/SMT family. {ECO:0000256|ARBA:ARBA00038188,
CC ECO:0000256|PROSITE-ProRule:PRU01022, ECO:0000256|RuleBase:RU362025}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEF52580.1}.
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DR EMBL; AMGV01000017; KEF52580.1; -; Genomic_DNA.
DR RefSeq; XP_013255170.1; XM_013399716.1.
DR AlphaFoldDB; A0A072PAG4; -.
DR STRING; 1182545.A0A072PAG4; -.
DR GeneID; 25286321; -.
DR VEuPathDB; FungiDB:A1O9_11423; -.
DR HOGENOM; CLU_039068_5_3_1; -.
DR OrthoDB; 275921at2759; -.
DR Proteomes; UP000027920; Unassembled WGS sequence.
DR GO; GO:0003838; F:sterol 24-C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR030384; MeTrfase_SMT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR013705; Sterol_MeTrfase_C.
DR PANTHER; PTHR44068:SF1; HYPOTHETICAL LOC100005854; 1.
DR PANTHER; PTHR44068; ZGC:194242; 1.
DR Pfam; PF08241; Methyltransf_11; 1.
DR Pfam; PF08498; Sterol_MT_C; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51685; SAM_MT_ERG6_SMT; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Lipid metabolism {ECO:0000256|RuleBase:RU362025};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01022}; Reference proteome {ECO:0000313|Proteomes:UP000027920};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01022};
KW Steroid biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Steroid metabolism {ECO:0000256|RuleBase:RU362025};
KW Sterol biosynthesis {ECO:0000256|RuleBase:RU362025};
KW Sterol metabolism {ECO:0000256|RuleBase:RU362025};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01022}.
FT DOMAIN 87..382
FT /note="SAM-dependent methyltransferase Erg6/SMT-type"
FT /evidence="ECO:0000259|PROSITE:PS51685"
SQ SEQUENCE 385 AA; 43021 MW; A786BECD99DBB1AB CRC64;
MAPAAVLSTH TLEAEDHARD ASFNKALHGK SSQARGGLAA MRNKDKAAQK AAIDEYFKHW
DNKAATVETE ETRKARRDQY ATLTRHYYNL ATDFYEYGWG TSFHFCRFAY GESFYRAIAR
HEHYLALKMG IQENARVLDV GCGVGGPARE MIKFTGANVV GLNNNDYQIE RSLRYAQKEG
IAHKWSAVKG DFMQMSFPEN SFDAVYAIEA TVHAPKLQGV YEQIYKVLKP GGVFGVYEWL
MTDNYDNDNP EHREIRLGIE QGDGISNMVK VSEGLAAIKA AGFELEHHED LAERPDAIPW
YYPLAGELKF ISSLGDLFTV ARMTWWGRGL MHKLLGVGES LRVMPAGTQK TGDSLALAAD
CLVAGGKQKL FTPMYLMVAR KPLNA
//
