ID A0A072PCC9_9EURO Unreviewed; 1177 AA.
AC A0A072PCC9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 22-FEB-2023, entry version 25.
DE RecName: Full=MIF4G domain-containing protein {ECO:0000259|SMART:SM00543};
GN ORFNames=A1O9_05334 {ECO:0000313|EMBL:KEF57417.1};
OS Exophiala aquamarina CBS 119918.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF57417.1, ECO:0000313|Proteomes:UP000027920};
RN [1] {ECO:0000313|EMBL:KEF57417.1, ECO:0000313|Proteomes:UP000027920}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF57417.1,
RC ECO:0000313|Proteomes:UP000027920};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEF57417.1}.
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DR EMBL; AMGV01000004; KEF57417.1; -; Genomic_DNA.
DR RefSeq; XP_013260007.1; XM_013404553.1.
DR AlphaFoldDB; A0A072PCC9; -.
DR STRING; 1182545.A0A072PCC9; -.
DR GeneID; 25280260; -.
DR VEuPathDB; FungiDB:A1O9_05334; -.
DR HOGENOM; CLU_002633_1_1_1; -.
DR OrthoDB; 276824at2759; -.
DR Proteomes; UP000027920; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR Gene3D; 1.25.40.180; -; 3.
DR Gene3D; 4.10.80.160; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR039762; Nmd2/UPF2.
DR InterPro; IPR007193; Upf2/Nmd2_C.
DR PANTHER; PTHR12839; NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2; 1.
DR PANTHER; PTHR12839:SF7; REGULATOR OF NONSENSE TRANSCRIPTS 2; 1.
DR Pfam; PF02854; MIF4G; 2.
DR Pfam; PF04050; Upf2; 1.
DR SMART; SM00543; MIF4G; 2.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000027920}.
FT DOMAIN 454..644
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT DOMAIN 659..867
FT /note="MIF4G"
FT /evidence="ECO:0000259|SMART:SM00543"
FT REGION 161..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 231..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..950
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1035..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1123..1141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1177 AA; 133574 MW; 1A1ED9819A4459D7 CRC64;
MDRKRKNVYN VADSLDSSLK KNTAFIKRLR TGLSASAQDT FLTETRTLSL QKYLSEIISA
TAEGLGRLKT SSEIATAVEV VSALHQRFGP AEFTRQLAWL LGRGLSPPDK AQVKLWTAEV
REREEKERLV RQRVLLRVVS EFWLCGILRS LDDVDRPDDA LTRTKESQIQ PESKPRPIPN
GLKSGSQIDH EPFPLEVLKE LLGHDPEHVN LSLAVLFVKN FSWDILGLKP PSDDSRKVPD
SESAAADPAK SGTDSDPLPE EDAPIIPQPI RERFVNVFER YLGSVKNHVV RDQKSLNNQS
RRNAEAYVKS GEIFEDRQAN FEKQSKAQEK LVANAQVLCD VLGQEMPELD EKDGPESAAT
GTVGMIKTGD YLKGQRDGAG IWEDEEERRF YENLVDLKGR VPGILLDDAK KTKNDSEERS
EATMSSTEIA PTKPISEADD QSTAIANKTV GAQVDAILLR LPDLQTKEMV DQVALDFCFL
NSKASRNRLI KAIQDVPKGR TDLLPLYARL TATLGQYMPD VVQGLIAHLN EEFRSLQRRK
TKDFLGQIRM SNIRYLAELT KFGIVPEHVI FHCFKVSLDD FSRMNIEIIA HLLENCGRYL
LRNPDASARM VSFLETLNRK KSAHHLGTQE RMLIENAMYY VDPPQRAAIQ QKERTPMELF
VRQLVYMDMT KRNYMKVLKT IRKLHWEETE VVQILEKIFS KPGKVKFSNI HLLAVLLQAL
FRYHQNFAIT VIDNVLENIT LGLEQNDFKF NQRRVAEVKY LGELYNYKMV DSTVIFDTLY
RLVTFGHEGG TPQPDAYTQF DPPDDFFRIR LVCTILDTCG ICFDRGSSRK KLDFFLTFFQ
YYMLTKDTLP MEIDFMAQDT FGLVRPNWKL VTDLPEAAKL FAEAVSANYK SQGAEKTSEQ
VEENEESGSD DGDGDGDADL DPVIVQSSDE EGELEGGEET AEEREDVDSD EDERIVVLRQ
AEELDPEAEA DFERAFEKMM AESLDSRKFE RRAQFDVPLP IRKIQRMPVE STEEEPSVMP
EPEANTMAFS LMTKKGNRQQ TRTIELPSDS SFALSMKSQQ AAEREEQQRI KNLVLNYDLR
EDEQHDGTPD GFLCGPIVQP PLENNPNTKG LKLGPDHYNP SLSRAEKSGR HAPRARRLNL
SDVDWYDPQT SSPTLATRSK ENHGKGFPVS KSKKKPG
//
