ID   A0A072PI54_9EURO        Unreviewed;       467 AA.
AC   A0A072PI54;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Arginosuccinase {ECO:0000256|ARBA:ARBA00032749};
GN   ORFNames=A1O9_03846 {ECO:0000313|EMBL:KEF59003.1};
OS   Exophiala aquamarina CBS 119918.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=1182545 {ECO:0000313|EMBL:KEF59003.1, ECO:0000313|Proteomes:UP000027920};
RN   [1] {ECO:0000313|EMBL:KEF59003.1, ECO:0000313|Proteomes:UP000027920}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 119918 {ECO:0000313|EMBL:KEF59003.1,
RC   ECO:0000313|Proteomes:UP000027920};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Walker B., Young S.K., Zeng Q.,
RA   Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Exophiala aquamarina CBS 119918.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|ARBA:ARBA00010755}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KEF59003.1}.
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DR   EMBL; AMGV01000003; KEF59003.1; -; Genomic_DNA.
DR   RefSeq; XP_013261593.1; XM_013406139.1.
DR   AlphaFoldDB; A0A072PI54; -.
DR   STRING; 1182545.A0A072PI54; -.
DR   GeneID; 25278780; -.
DR   VEuPathDB; FungiDB:A1O9_03846; -.
DR   HOGENOM; CLU_027272_2_1_1; -.
DR   OrthoDB; 2722228at2759; -.
DR   UniPathway; UPA00068; -.
DR   Proteomes; UP000027920; Unassembled WGS sequence.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:InterPro.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:KEF59003.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027920}.
FT   DOMAIN          16..311
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          374..441
FT                   /note="Argininosuccinate lyase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14698"
SQ   SEQUENCE   467 AA;  52039 MW;  140732729548027C CRC64;
     MSQSAKNENP IRLWGGRFTG EIDPLMNQYN ESLSVDRVFY AQDIKGSIAY ARANVKTGIL
     TQKEFEKLEE GLKVVLKEWE EGKFQPAPGD EDIHTANERR LGEVIGRDVA GKLHTGRSRN
     DQVATDMRMW LRDELIAIEG YLVDLLKVIA HRAKQDIDYI MPSYTHLQRA QPVRWSQWLL
     SHATAFQSDL ERLRFTKKNI NKLPLGCGAV AGNAFGIDRV QLATELGFDG LIMNSMSAVG
     DRDFVVEVLQ CASTIGSHLS RWSEDLIIYS SSEFGYVKLA DAYTTGSSLM PQKKNSDSLE
     LLRGKSGRIF GSMAGLMMSI KGIPSTYNKD LQESLQPMLD TIKTLKDGLQ IAARSLATAT
     VYPEKMRAAL SPDMLATDLA EYLVRKGVPF RETHHLAGRM VALAEDENKG MDKLTVAQFQ
     GVDKRFGDDV LSVFDYERSV ELKDATGGTS RRAVLEQLDA LTKTLGE
//