ID A0A072TSV7_MEDTR Unreviewed; 813 AA.
AC A0A072TSV7;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=LRR and NB-ARC domain disease resistance protein {ECO:0000313|EMBL:KEH20502.1};
DE SubName: Full=Putative powdery mildew resistance protein, RPW8 {ECO:0000313|EMBL:RHN42199.1};
GN Name=25502904 {ECO:0000313|EnsemblPlants:KEH20502};
GN OrderedLocusNames=MTR_8g479430 {ECO:0000313|EMBL:KEH20502.1};
GN ORFNames=MtrunA17_Chr8g0374291 {ECO:0000313|EMBL:RHN42199.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH20502.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH20502.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH20502.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH20502,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH20502.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH20502.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH20502,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH20502}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH20502};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|Proteomes:UP000265566}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 4:1017-1025(2018).
RN [5] {ECO:0000313|EMBL:RHN42199.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN42199.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
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DR EMBL; CM001224; KEH20502.1; -; Genomic_DNA.
DR EMBL; PSQE01000008; RHN42199.1; -; Genomic_DNA.
DR RefSeq; XP_013446475.1; XM_013591021.1.
DR AlphaFoldDB; A0A072TSV7; -.
DR EnsemblPlants; KEH20502; KEH20502; MTR_8g479430.
DR GeneID; 25502904; -.
DR Gramene; KEH20502; KEH20502; MTR_8g479430.
DR KEGG; mtr:25502904; -.
DR HOGENOM; CLU_012216_0_0_1; -.
DR OrthoDB; 1208714at2759; -.
DR Proteomes; UP000002051; Chromosome 8.
DR Proteomes; UP000265566; Chromosome 8.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR PANTHER; PTHR36766:SF3; PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF05659; RPW8; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 4: Predicted;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 1..153
FT /note="RPW8"
FT /evidence="ECO:0000259|PROSITE:PS51153"
SQ SEQUENCE 813 AA; 92321 MW; 6A86C144FE993272 CRC64;
MAMVLDAVVG KLVEELMSSV VDMKNKALKF KPTLDRLEAT LQSLGPLINQ IDELKKKLDH
SPNETKTLIK QMKDGKELVL KCSNEDKIQW WNCCYKKAQY QEQLEALDEE IKRFFGLDMI
AQGAVTGLET LLEIKEFRAE FSKANVGRSE RVELRGVCLP PQPPGFIVGL DGPLNELKMR
LLKDEVSVSV VTVTGSGGSG KSTLAKRFCW DEEVKGKFNE NIFFITFAKT PKLNTIVQKL
YQHTGYYVPD FQNEEDTFNQ LEHLMKQVVK KGPILLVLDD VWLGSESLVD NFVFEIPNYK
ILVTSRFAIG RFGHPFVLKP LSEAHAINLF KHSASLTKST SDVPDDVVKE IVRGCSGSPL
ALRVSGRSLI NEQLIVWLNR ARELSAGRSI LDSNKDVLSC LQKSLDVLDP MSMECFRDLG
LFPEDQRIPA AALIDMWAEL RNDDDASAME RIYKLVNLNL ADIIVTRKVA SGTIDYNYHY
VTQHGLLRDL AIRDNSQEAE DKRNRLIIDT SANNLPSWWT SENEYHIKAR ILSISTDEIF
TSKWCNLQPT EVEVLVLNLR EKKFALPMFM KKMKKLKALI ITNYDFFPAE LENFEVLDHL
SNLKRIRLEK VSVPFLGKTV LQLKNLQKCS FFMCNVNKAF ENCTIEDSEM LPNLMEMNFD
YCDMVELPNV ISNIVSLKKL SITNCHKLCA LHEGIGKLVN LESLRLSSCS GLLELPNSIR
NLHVLKFLNI SGCISLSQLP ENIGELEKLE KLNMRGCSNI SELPSSVMEL EGLKHVVCGD
EETAEKWEPY KNILGDLKVE VVQEDFNLNF LYN
//
