ID A0A072U1Z5_MEDTR Unreviewed; 1142 AA.
AC A0A072U1Z5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:KEH23203.1};
GN OrderedLocusNames=MTR_7g069120 {ECO:0000313|EMBL:KEH23203.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH23203.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH23203.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH23203.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH23203,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH23203.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH23203.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH23203,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH23203}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH23203};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001223; KEH23203.1; -; Genomic_DNA.
DR RefSeq; XP_013449176.1; XM_013593722.1.
DR AlphaFoldDB; A0A072U1Z5; -.
DR EnsemblPlants; KEH23203; KEH23203; MTR_7g069120.
DR Gramene; KEH23203; KEH23203; MTR_7g069120.
DR HOGENOM; CLU_001561_0_2_1; -.
DR Proteomes; UP000002051; Chromosome 7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF290; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 69..232
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1142 AA; 130465 MW; 37E594F8BC60E1B0 CRC64;
MAAKFEIEKF NGRNFFLWKL KIREILREDN CLDAIDVRPA DITDGKWKEM DDNVVANLHI
DANDGLSIVK YDVFISFRGP DTRNSFVDHL YDHLTRKGIF VFKDDKSLQK GESISLQLLQ
AIKDSRVSII VFSKDYASST WCLDEMAAID ESSRRLKQVV FPVFYDIDPS HVRKRSGAYE
DAFVLHTKQC SDKVDQWRTA MTYLAGSAGW DVRNQPESVM IEEMVQAVIE KLGHTYSASI
DDLFGIQPHI EALEGLLRLQ SEDDGCRVVG IRGMDGIGKT ALAKVLYDRI SYQFDACCFI
ENVSKIYEDG GAVAVQKQIL CRTIKEKNID TYSPPNISQI MRNRLCKIKL LIVLDNVEQL
EQLEELDIQP VFLHTGSRII TIARDKHILQ AYGANDVFEA KLMNPEDARK LFCRKAFKSD
YPSSGFAELI SKVLKYANRL PLAVKVLGSF LFSRNANQWN STLDKFEKNP PNKIMKVLNV
SYEGLEQDEK EVFLHVACFF NGERRDYVSR ILDACGLNPG INIPLLAEKS LITIINEEIY
MHEMLHKLGK QIVREQHPDK PDLWSRMWLY RDFHDAMISN SEAVKAKAII INQKDDVSKF
NQLSTEGLSK MENLVVLILY HTNFSGRPTS FSDSLRYVLW NGYPFMSLPS EFQPYQLVEL
NMPDSSIEQL WIGIKRLDLT GCINLSHVDP SIGLLEELVF LSLQNCTSLV SLVFGNAPVL
RSLRVLRLSD CTKLGNTPDL SGTLILQYVD MDRCASLSTI HESIGALAKL KFISFRDCTN
LVGIPDTFYK MKSLITLDLH GCSKFTNLPL RWISASPLQS LTYLDLSFCC IFNIPDAIGE
LRCLERLNLQ GNGFTTVPSS LCYGLSYLNL SHCHKLQSFS LIETKSARLN SVGRLHLDLE
PLQFRCGFDI VLPWHGKPNA SHPFLDDIPN FFHQRFVGSI PDNIPKKFHH RFEGGSIVRI
NNSIMEVDWV GFLFYVTFEL NNHPILSSYT HQILSQPLPH PFYLSFESEY TEERFDMQLN
LELNKVDGKH YLWTIYISRE HCHFVKTRAD ITFKASEGLI IKEWGLRVLT KEDIEASEVG
QSIHLPLENV NVTQSRSSSF DPTKIQHPYN WLVSKEDEAE KDEAKGKETD LFNLGLLTEK
PQ
//
