ID A0A072UL34_MEDTR Unreviewed; 876 AA.
AC A0A072UL34;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:KEH29798.1};
GN OrderedLocusNames=MTR_4g051698 {ECO:0000313|EMBL:KEH29798.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH29798.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH29798.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH29798.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH29798,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH29798.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH29798.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH29798,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH29798}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH29798};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001220; KEH29798.1; -; Genomic_DNA.
DR RefSeq; XP_013455767.1; XM_013600313.1.
DR AlphaFoldDB; A0A072UL34; -.
DR STRING; 3880.A0A072UL34; -.
DR EnsemblPlants; KEH29798; KEH29798; MTR_4g051698.
DR Gramene; KEH29798; KEH29798; MTR_4g051698.
DR HOGENOM; CLU_001561_5_1_1; -.
DR Proteomes; UP000002051; Chromosome 4.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF219; ARCHAEAL ATPASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 16..185
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 876 AA; 99851 MW; 72476C2B4C4558F2 CRC64;
MAMQSPSSSS SFSYRFTYQV FLSFRGTDTR DGFTGHLYKA LTDKGIHTFI DDRDLQSGDE
IKPSLDNAIE ESRIFIPVFS INYASSSFCL DELVHIIHCY KTKGRLVLPV FYGVDPTHIR
HQSGSYGEHL TKHGKSFQNN KKNMERLHQW KLALTEAANL SGYHFSSGYE YKFIGDIVKY
VSNKISRQPL HVANYPVGLQ SRVQQVKALL DKGSDDGVRM LGLYGIGGMG KSTLAKAIYN
FIADQFECSC FLENVRENSA SNQLKHLQEE LLLKTLALKI KLGGVSEGIP YIKERLHTKK
ILLILDDVDN LEQLHALAGG RDWFGCGSRV IITTRNKHLL TNHEIEIIHE VKGMSTENAL
ELLRWMAFKN YKVPSSYEEI FNHAVVYASG LPLALEVVGS NLFGKSFAEC DSTLDKYERI
PHEDIQKILK VSFDALDEEQ QSVFLDIACF FKGCSLAEVE EILQRHYGYR INSHIRGLVD
KSLIKCHLNE VTLHDLLEAM GKEIVRKESP KEPEKRSRLW CRDDIIHILQ ENKGTSKIEM
IYLSSPSTDP VIDWNGKAFK KMTNLKTLII ENVSFSKDPK YLPSSLRVLK LNGCSTESLS
SCICSKRFED MKVLTLDNCQ YLTHIPNVSG LPNLEEFSFE KCNNLIAIHD SIRNLNKLEI
INACGCSKLE SFPPLWLPSL KELDISYCRR LKSFPELLCK MTNTKEIGMC TTSTRELPFS
FQNLSLSLKG CKMLRFSKHD DVMYSTMFSN VEALHLNPYY LPYECLQIVL KSCVNVKYLN
LSLGKFKILP ECLSECHLLR TLLLDFNRHL EEIRGLPPNL KYLDAYRCKS LSSSSRRMLL
SQQLHEAGCT KFSFPNGTEG IPDWFEHQSR GQSISF
//
