ID A0A072ULU9_MEDTR Unreviewed; 1000 AA.
AC A0A072ULU9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) {ECO:0000313|EMBL:KEH26800.1};
GN Name=25496679 {ECO:0000313|EnsemblPlants:KEH26800};
GN OrderedLocusNames=MTR_6g074875 {ECO:0000313|EMBL:KEH26800.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH26800.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH26800.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH26800.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH26800,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH26800.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH26800.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH26800,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH26800}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH26800};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001222; KEH26800.1; -; Genomic_DNA.
DR RefSeq; XP_013452772.1; XM_013597318.1.
DR AlphaFoldDB; A0A072ULU9; -.
DR STRING; 3880.A0A072ULU9; -.
DR EnsemblPlants; KEH26800; KEH26800; MTR_6g074875.
DR Gramene; KEH26800; KEH26800; MTR_6g074875.
DR HOGENOM; CLU_001561_5_0_1; -.
DR Proteomes; UP000002051; Chromosome 6.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF219; ARCHAEAL ATPASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 16..186
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1000 AA; 114530 MW; 1D4E9C1676D5D49E CRC64;
MAIQSPSSSS SFSHGFTYQV FLSFRGTDTR HSFTGNLYKA LTDKGIHTFI DDNDLQRGDE
ITPSLLKAID ESRIFIPVFS INYASSSFCL DELVHIIHCY KTKGRLVLPV FFGVEPTNVR
HQKGSYGEAL AEHEKRFQND KNNMERLQRW KVALSQAANL SGYHDSPPGY EYEFIGEIVK
YISNKTSRQP LHVANYPVGL QSRVQQVKSL LDERSDDGVH MVGLYGTGGL GKSTLAKAIY
NFIADQFECS CFLENVRENS TSNKLKHLQK ELLLKTLQLE IKFGGVSEGI PYIKERLHRK
KVLLILDDVD NMKQLHALAG GPDWFGRGSK VIITTRDKHL LTCHGIKSMH EVEGLYGTEA
LELLRWMAFK SDNVPSGYEE ILNRAVAYAS GLPLVIEIVG SNLSGKNIEE WKNTLDGYDR
IPNKEIQKIL KVSYDALEEE QQSVFLDIAC CFKRCKWEDA KYILNSHYGH CITHHLGVLV
EKSLIKKLRE YDDYVMLHDL IEDMGKEVVR QESIKEPGER SRLCCQDDIV RVLRENTGTS
KIEMIYMNLH SMESVIDKKG KAFKKMTKLK TLIIENGHCS KGLKYLPSSL SVLKWKGCLS
KCLSSRILNK KFQDMKVLIL DRCKYLTHIP DVSGLSNLEK LSFERCYNLI TIHNSIGHLN
KLERLSAYGC NKVEHFPPLG LASLKELNLS SCRSLKSFPE LLCKMTNIDN IWLCNTSIGE
LPFSFQNLSE LHKLSVTYGM LRFPKQNDKM YSIVFSNVTQ LTLYHCNLSD ECLRRVLKWC
VNMTSLNLLY SNFKILPECL SECHHLVEIN VGYCESLEEI RGIPPNLKEI NAQGCQSLSS
SSKRILMSQK LHQAGCTYIK FPNGTDGIPD WFEHQSRGPT ISFWFRKEIP SITCIIIFPE
CAWGSNVGLY VNGYKIEIDY CYQYVSSKDT TLIHMKLYEL GKRQYEYNMD KGLLKSEWIH
VEFKLKDHEN SVYTQMGVHV WNEKSNTEEE NVVFKDPYLN
//
