ID A0A072V1H0_MEDTR Unreviewed; 798 AA.
AC A0A072V1H0;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Cation/H+ exchanger 3 {ECO:0000313|EMBL:KEH35687.1};
DE SubName: Full=Putative cation/H+ exchanger {ECO:0000313|EMBL:RHN70080.1};
GN Name=25491142 {ECO:0000313|EnsemblPlants:KEH35687};
GN OrderedLocusNames=MTR_3g498715 {ECO:0000313|EMBL:KEH35687.1};
GN ORFNames=MtrunA17_Chr3g0131701 {ECO:0000313|EMBL:RHN70080.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH35687.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH35687.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH35687.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH35687,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH35687.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH35687.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH35687,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH35687}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH35687};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
RN [4] {ECO:0000313|EMBL:RHN70080.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Leaves {ECO:0000313|EMBL:RHN70080.1};
RA Pecrix Y., Gamas P., Carrere S.;
RT "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL Nat. Plants 0:0-0(2018).
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000256|ARBA:ARBA00038341}.
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DR EMBL; CM001219; KEH35687.1; -; Genomic_DNA.
DR EMBL; PSQE01000003; RHN70080.1; -; Genomic_DNA.
DR RefSeq; XP_013461652.1; XM_013606198.1.
DR AlphaFoldDB; A0A072V1H0; -.
DR EnsemblPlants; KEH35687; KEH35687; MTR_3g498715.
DR GeneID; 25491142; -.
DR Gramene; KEH35687; KEH35687; MTR_3g498715.
DR KEGG; mtr:25491142; -.
DR HOGENOM; CLU_005126_6_1_1; -.
DR OrthoDB; 943984at2759; -.
DR Proteomes; UP000002051; Chromosome 3.
DR Proteomes; UP000265566; Chromosome 3.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR PANTHER; PTHR32468:SF97; CATION_H+ EXCHANGER 3; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 90..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 291..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..398
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..449
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 798 AA; 89475 MW; ABB214CB31B315B9 CRC64;
MGIGSTDDTL FKSMNETSMS NNVVNSNLLN YNVCISTPPN ILSHGIWGKH ESEGSPFRSS
FPVFLHQVIL IYVTTRAINF PIKQLGLPKL ISQMMAGLIL GPAVPIFLDL KRNLFPYGSQ
DTLATIAGLG YVLFLFETGV KMDFNMIRRT GRKGWTISLL GLVTPMLIGL CFSIWDPKHR
NVFNKESIEK GIILLGHNTT SFAVIVSLLK DLKLLNSELG RLALSVALVG EILSNIFITV
TSTLLDQGHY ISPVMRLGYL FAITLFILLI YRPAMFWIVE HTPEGKEVKD IYINIVIGIL
FCLCWLSGEL EKGPVFLPFI LGLATPEGPP LGSTLIKRVH LLGIKLFLPI YMTTSTMKVE
YGFWRSSYSG STLETSLFVL FTGYFLKMVA CFLSSLIFNM PLKDGISLAL LLNCKGVVEV
NMYSTALDRN DIRPKIYCVV IFIIMVSICS THLLVKHLYD PSRKYAGYQK RNIFSLKPDS
ELKILVCIHK PHHITPMTEV IDLCDPIVEY PVTVDALHLI ELAGRASPIF ISHKKKKVVS
LNLHDSYSDN VVLSLKLYES DKQGAAIVNP YTAISPLNLM HEDVCHLALD KVSSIIFLPF
HKKWSSDGKL EYDDKNIRSL NRNILEKSPC SVGILVTRFV HQTDSSLRLA LVFLGGRDDR
EALYLAKRAA RVSSIELVIY HIVDKNKSDK DQESMDAVLD KAVLKDVYVE HCRMENVTFR
EIKVEDGSQT LDVLRGMVKE HNFIIVGRRN GVNSPQTYGL QHWSEFPELG PVGDYLASSD
LGCKSSILVV QQQQQICT
//
