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Database: UniProt
Entry: A0A072V1N5_MEDTR
LinkDB: A0A072V1N5_MEDTR
Original site: A0A072V1N5_MEDTR 
ID   A0A072V1N5_MEDTR        Unreviewed;      1086 AA.
AC   A0A072V1N5;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   05-JUN-2019, entry version 29.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=25489857 {ECO:0000313|EnsemblPlants:KEH35606};
GN   OrderedLocusNames=MTR_3g096525 {ECO:0000313|EMBL:KEH35606.1};
GN   ORFNames=MtrunA17_Chr3g0130421 {ECO:0000313|EMBL:RHN69961.1};
OS   Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae;
OC   50 kb inversion clade; NPAAA clade; Hologalegina; IRL clade;
OC   Trifolieae; Medicago.
OX   NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH35606.1, ECO:0000313|Proteomes:UP000002051};
RN   [1] {ECO:0000313|EMBL:KEH35606.1, ECO:0000313|EnsemblPlants:KEH35606, ECO:0000313|Proteomes:UP000002051}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A17 {ECO:0000313|EMBL:KEH35606.1}, and cv. Jemalong A17
RC   {ECO:0000313|EnsemblPlants:KEH35606,
RC   ECO:0000313|Proteomes:UP000002051};
RX   PubMed=22089132; DOI=10.1038/nature10625;
RA   Young N.D., Debelle F., Oldroyd G.E.D., Geurts R., Cannon S.B.,
RA   Udvardi M.K., Benedito V.A., Mayer K.F.X., Gouzy J., Schoof H.,
RA   Van de Peer Y., Proost S., Cook D.R., Meyers B.C., Spannagl M.,
RA   Cheung F., De Mita S., Krishnakumar V., Gundlach H., Zhou S.,
RA   Mudge J., Bharti A.K., Murray J.D., Naoumkina M.A., Rosen B.,
RA   Silverstein K.A.T., Tang H., Rombauts S., Zhao P.X., Zhou P.,
RA   Barbe V., Bardou P., Bechner M., Bellec A., Berger A., Berges H.,
RA   Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA   Deshpande S., Dai X., Doyle J.J., Dudez A.-M., Farmer A.D.,
RA   Fouteau S., Franken C., Gibelin C., Gish J., Goldstein S.,
RA   Gonzalez A.J., Green P.J., Hallab A., Hartog M., Hua A.,
RA   Humphray S.J., Jeong D.-H., Jing Y., Jocker A., Kenton S.M.,
RA   Kim D.-J., Klee K., Lai H., Lang C., Lin S., Macmil S.L.,
RA   Magdelenat G., Matthews L., McCorrison J., Monaghan E.L., Mun J.-H.,
RA   Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA   Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C.,
RA   Sallet E., Samain S., Samson N., Sanders I., Saurat O., Scarpelli C.,
RA   Schiex T., Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S.,
RA   Singer S.R., Sinharoy S., Sterck L., Viollet A., Wang B.-B., Wang K.,
RA   Wang M., Wang X., Warfsmann J., Weissenbach J., White D.D.,
RA   White J.D., Wiley G.B., Wincker P., Xing Y., Yang L., Yao Z., Ying F.,
RA   Zhai J., Zhou L., Zuber A., Denarie J., Dixon R.A., May G.D.,
RA   Schwartz D.C., Rogers J., Quetier F., Town C.D., Roe B.A.;
RT   "The Medicago genome provides insight into the evolution of rhizobial
RT   symbioses.";
RL   Nature 480:520-524(2011).
RN   [2] {ECO:0000313|EMBL:KEH35606.1, ECO:0000313|EnsemblPlants:KEH35606, ECO:0000313|Proteomes:UP000002051}
RP   GENOME REANNOTATION.
RC   STRAIN=A17 {ECO:0000313|EMBL:KEH35606.1}, and cv. Jemalong A17
RC   {ECO:0000313|EnsemblPlants:KEH35606,
RC   ECO:0000313|Proteomes:UP000002051};
RX   PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA   Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA   Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA   Schwartz D.C., Town C.D.;
RT   "An improved genome release (version Mt4.0) for the model legume
RT   Medicago truncatula.";
RL   BMC Genomics 15:312-312(2014).
RN   [3] {ECO:0000313|EnsemblPlants:KEH35606}
RP   IDENTIFICATION.
RC   STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH35606};
RG   EnsemblPlants;
RL   Submitted (APR-2015) to UniProtKB.
RN   [4] {ECO:0000313|Proteomes:UP000265566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Jemalong A17 {ECO:0000313|Proteomes:UP000265566};
RX   PubMed=30397259; DOI=10.1038/s41477-018-0286-7;
RA   Pecrix Y., Staton S.E., Sallet E., Lelandais-Briere C., Moreau S.,
RA   Carrere S., Blein T., Jardinaud M.F., Latrasse D., Zouine M., Zahm M.,
RA   Kreplak J., Mayjonade B., Satge C., Perez M., Cauet S., Marande W.,
RA   Chantry-Darmon C., Lopez-Roques C., Bouchez O., Berard A., Debelle F.,
RA   Munos S., Bendahmane A., Berges H., Niebel A., Buitink J., Frugier F.,
RA   Benhamed M., Crespi M., Gouzy J., Gamas P.;
RT   "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL   Nat. Plants 4:1017-1025(2018).
RN   [5] {ECO:0000313|EMBL:RHN69961.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Leaves {ECO:0000313|EMBL:RHN69961.1};
RA   Pecrix Y., Gamas P., Carrere S.;
RT   "Whole-genome landscape of Medicago truncatula symbiotic genes.";
RL   Nat. Plants 0:0-0(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; CM001219; KEH35606.1; -; Genomic_DNA.
DR   EMBL; PSQE01000003; RHN69961.1; -; Genomic_DNA.
DR   RefSeq; XP_013461571.1; XM_013606117.1.
DR   STRING; 3880.AES72896; -.
DR   EnsemblPlants; KEH35606; KEH35606; MTR_3g096525.
DR   GeneID; 25489857; -.
DR   Gramene; KEH35606; KEH35606; MTR_3g096525.
DR   KEGG; mtr:MTR_3g096525; -.
DR   KO; K02327; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000002051; Chromosome 3.
DR   Proteomes; UP000265566; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002051,
KW   ECO:0000313|Proteomes:UP000265566};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442,
KW   ECO:0000313|EMBL:RHN69961.1};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW   Transferase {ECO:0000256|RuleBase:RU000442,
KW   ECO:0000313|EMBL:RHN69961.1}; Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      118    462       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      526    959       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      996   1067       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     29       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A072V1N5}.
SQ   SEQUENCE   1086 AA;  122696 MW;  643154D47C061762 CRC64;
     MNKSNSRKRP AAPPSQPPPS KHAASQEEEF MDEDVFLDEN LISEDEESAI LRDIEQRQAL
     ASRLAKWNRP PLSQEYLSQS CSVLFQQLEI DYVIGESRKE FTPKISGPAA IIRIFGVTKE
     GHSVCGKVHG FQPYFYINCP PGMRLEDLSS FQKVLEARMR EANRNSNVQG NYVRDVVFVQ
     KKSIMYYQQT DLHPFIKITV ALPTMVASCR GILDRGIQID GLGMKSFMTY ESNVLFALRF
     MIDCNIVGGN WIEIPAGKYK KTTKSLSYCQ LEFDCLYSDL ISHAPEGEYS RMAPFRILSF
     DIECAGRKGH FPEPTHDPVI QIANLVTLQG EDQPLIRNVM TLNSCSPIVG VDVMSFDTEG
     EVLLAWRDFI REVDPDIIIG YNICKFDLPY LIERAATLKI AEFPILGRIR NSRVRVKDTT
     FSSRQYGIRE SKEVTVEGRV QFDLLQVMQR DYKLSSYSLN SVSAHFLSEQ KEDVHHSIIS
     DLQNGNAETR RRLAVYCLKD AYLPQRLLDK LMFVYNYVEM ARVTGVPISF LLSRGQSIKV
     LSQLLRKAKQ KNLVIPNAKQ AGSEQGTFEG ATVLEARAGF YEKPIATLDF ASLYPSIMMA
     YNLCYCTLVT PENARMLNIP LESMNKTPSG ETFVKSNLQK GILPEILEEL LAARKRAKAD
     LKEAKDPLEK AVLDGRQLAL KISANSVYGF TGASIGQLPC LEISSSVTSY GRQMIEHTKK
     LVEEKFTRLN GYDNNAEVIY GDTDSVMVQF GVSTVKDAMD LGKEAAEHIS GTFTKPIKLE
     FEKVYCPYLL ISKKRYAGLF WTKEDSHDKM DTKGIETVRR DNCLLVKNLV NDCLHKILIE
     KNIPAAVQHV KNAISDLLMN RMDLSLLVIT KGLTKTGDDY EVKTAHVELA ERMRKRDAAT
     APNVGDRVPY VIIKAAKGAK AYERSEDPIY VLENNIPIDP QYYLENQISK PILRIFEPIL
     KNASKELLHG SHTRSISIST PSNSGIMKFA KKQYTCIGCK ALLSTGISTL CIHCKGREAE
     LYCKTVAQVS DLEVLFGRLW TQCQECQGSL HQDVLCTSRD CPIFYRRKKA QKDMAEARLQ
     LDRWSF
//
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