ID A0A072V4B3_MEDTR Unreviewed; 813 AA.
AC A0A072V4B3;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Cation/H+ exchanger 3 {ECO:0000313|EMBL:KEH36491.1};
GN Name=25485906 {ECO:0000313|EnsemblPlants:KEH36491};
GN OrderedLocusNames=MTR_2g011520 {ECO:0000313|EMBL:KEH36491.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH36491.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH36491.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH36491.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH36491,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH36491.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH36491.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH36491,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH36491}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH36491};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC {ECO:0000256|ARBA:ARBA00038341}.
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DR EMBL; CM001218; KEH36491.1; -; Genomic_DNA.
DR RefSeq; XP_013462456.1; XM_013607002.1.
DR AlphaFoldDB; A0A072V4B3; -.
DR EnsemblPlants; KEH36491; KEH36491; MTR_2g011520.
DR GeneID; 25485906; -.
DR Gramene; KEH36491; KEH36491; MTR_2g011520.
DR KEGG; mtr:25485906; -.
DR HOGENOM; CLU_005126_6_2_1; -.
DR OrthoDB; 6504at2759; -.
DR Proteomes; UP000002051; Chromosome 2.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR PANTHER; PTHR32468:SF104; CATION_H+ EXCHANGER 3; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 146..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..409
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 813 AA; 89140 MW; 2FC09561102335E4 CRC64;
MTTTNGVWAG ENPLNYSIPL FILQITLVVF TTRFFVFILK PFHQPRVIAE IMGGLFLGPS
VLGRHENFAN IVFPLKSAMV LETMANIGLI YFLFLIGLEM DISIVKRTGA KAVSIAVAGM
ILPFIVGLGV SFAFTGRDES VNDFSFVLYL GIVLSVTSFP VLARMLAELK LINTELGKLS
LSTSLINDVC AWLLLALAIA LSENNSTTWA SVYVVISNLF FVGFCFLVVR PAITWLIKKT
PEGKPFSDFQ ICAVLVGVMI SALITDVIGT HSIFGAFVYG LVIPNGPLGA AIIEKLEDFV
SGLLLPLFYA ISGLKTNINL FNKGGSWAFV LTIVPLTCLG KIIGTVIVSI LFDLPARDGI
VLGLLMNTKG LIEMIVLNIG REQKVLGDEI FSIMVIVTLI MTAIISPIVA LIYRPRKRLI
PYRKRTVQSS RVDAELRVLV CIHAPRNVPT IVNLLEATHP NKRSPICAYV LHLVELTGRA
SAMLVVHASG QSGGPALNKT QAQTEHIITA FQNLEDHVGY VSTQPLTAVS PYSTMHEDIC
NLAEEKRVST IIIPFHKQQT VDGEMQETNP ALRMVNHNLL QSSPCSVGIL VDRGLNGSSR
LTASQASHQV AVLFFGGPDD REALSYGWRM SRHPRVHLTV MHFISGKDVT ESLIDDELLD
NQRSTISNKI DEECINEIKM LATCDVSIKY IEKIVSNGEQ TVSAIRETNN ANDLFIVGRG
QGDSSPLTEG LTDWSECPEL GAIGDLLASS DFETSASVLV MHQYVGQGPE GEDLFVCERP
WQSSDNFNSL RQKHRGRYAA MPMETDTYSS EFL
//
