ID A0A072V7A5_MEDTR Unreviewed; 1001 AA.
AC A0A072V7A5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class), putative {ECO:0000313|EMBL:KEH34050.1};
GN OrderedLocusNames=MTR_3g058670 {ECO:0000313|EMBL:KEH34050.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH34050.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH34050.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH34050.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH34050,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH34050.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH34050.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH34050,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH34050}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH34050};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
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DR EMBL; CM001219; KEH34050.1; -; Genomic_DNA.
DR RefSeq; XP_013460019.1; XM_013604565.1.
DR AlphaFoldDB; A0A072V7A5; -.
DR EnsemblPlants; KEH34050; KEH34050; MTR_3g058670.
DR Gramene; KEH34050; KEH34050; MTR_3g058670.
DR HOGENOM; CLU_001561_0_0_1; -.
DR Proteomes; UP000002051; Chromosome 3.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF588; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002051}.
FT DOMAIN 35..110
FT /note="TIR"
FT /evidence="ECO:0000259|Pfam:PF01582"
FT DOMAIN 120..352
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1001 AA; 114746 MW; 0F02BCD8C844632C CRC64;
MSFKKEMRSR QHSSKPLRSH MHLLSSSQKT MLPQNDPSHV RKQTGSYKQA FEKHKRDLKH
NNDKLEKWKA ALTEAANLVG WDSRNYRIES DFIKDIVEDV LQKLNLRYPY EIKGLVGVEK
NYDQIESILK IESNDVGILG IWGMGGIGKT TLARTLYAKL YSQFEGRCFL NVMDESNKYG
VNGLHNKFFS SLLEEENLHP DASYIESSFS VRRIARKRVF VVLDGVETLE QIEDLILKID
ALGPGSRVII TTRDKHIFSQ FSKCEIYEVK ELNKRDSLQL FCLSAFREKH PNIGYEDLSE
RVIAYCQGNP LALKVLGANL SSRGKKEWKN ELKKLQKIPN RKIYNVLKLS YDDLDCSQKA
IFLDITCFFR GESKFHVTHM LEACEFFAKS GIEVLLDKAL IQLQLFWHWQ FKSETDGLEM
HDLLQEMGQE IVNQESKDPG KRSRLWKAEE ISDLLKENKG TEVVEGIIFD STEVGDLYLK
SDSFKRMTNL RYLDIYYNIS NGSICNVHLP DGLECLSDKL RYLQWDGYCL ESLPSTFCAE
MLIELHMTHC KLKKLWDGVQ NLVNLRSIML QSSKDLIEIP DLSRATNLER VYLCQCESLR
QLHPSIFSLP RLIFLDLEDC IKIESLKTNI HSKSLCKLKL GGCSSLIEFS VTSEEMTKLT
LHGTAIRELS SSIWRNRKLT SLGLTECKNL NFVGNKLSND QGLGSVTELD LSGCTEINAL
SLWSILDGIQ SLKRLKLKEC CNLECLPENI RNHSMLKRLD LDDCRKLVSL AELPPSLLYL
KAVNCNYLDT NSTQRLLLEN MVQNFSTDTP DEDGVFHFSL LPGAQVPCNF DFKTVEASIS
IPPIPKSYLC GFIFCIVLSE GFSVYEHSLH CVIFEHGKEV DRCRISCNYL GALILDHVLI
CWHRYSIQES GSYDFCNLSF QFILQGHKEK LWWSTEGIKG CGVLPLYDLE RELEGDSSSI
TRTQDSEGDD TDEVESSNNE NEDDQKHPWC CSIGMNLFTH F
//
