ID A0A072VRL1_MEDTR Unreviewed; 870 AA.
AC A0A072VRL1;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Extra-large GTP-binding protein {ECO:0000313|EMBL:KEH40765.1};
GN Name=25482678 {ECO:0000313|EnsemblPlants:KEH40765};
GN OrderedLocusNames=MTR_1g034300 {ECO:0000313|EMBL:KEH40765.1};
OS Medicago truncatula (Barrel medic) (Medicago tribuloides).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Trifolieae; Medicago.
OX NCBI_TaxID=3880 {ECO:0000313|EMBL:KEH40765.1, ECO:0000313|Proteomes:UP000002051};
RN [1] {ECO:0000313|EMBL:KEH40765.1, ECO:0000313|Proteomes:UP000002051}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A17 {ECO:0000313|EMBL:KEH40765.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH40765,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=22089132; DOI=10.1038/nature10625;
RA Young N.D., Debelle F., Oldroyd G.E., Geurts R., Cannon S.B., Udvardi M.K.,
RA Benedito V.A., Mayer K.F., Gouzy J., Schoof H., Van de Peer Y., Proost S.,
RA Cook D.R., Meyers B.C., Spannagl M., Cheung F., De Mita S.,
RA Krishnakumar V., Gundlach H., Zhou S., Mudge J., Bharti A.K., Murray J.D.,
RA Naoumkina M.A., Rosen B., Silverstein K.A., Tang H., Rombauts S.,
RA Zhao P.X., Zhou P., Barbe V., Bardou P., Bechner M., Bellec A., Berger A.,
RA Berges H., Bidwell S., Bisseling T., Choisne N., Couloux A., Denny R.,
RA Deshpande S., Dai X., Doyle J.J., Dudez A.M., Farmer A.D., Fouteau S.,
RA Franken C., Gibelin C., Gish J., Goldstein S., Gonzalez A.J., Green P.J.,
RA Hallab A., Hartog M., Hua A., Humphray S.J., Jeong D.H., Jing Y.,
RA Jocker A., Kenton S.M., Kim D.J., Klee K., Lai H., Lang C., Lin S.,
RA Macmil S.L., Magdelenat G., Matthews L., McCorrison J., Monaghan E.L.,
RA Mun J.H., Najar F.Z., Nicholson C., Noirot C., O'Bleness M., Paule C.R.,
RA Poulain J., Prion F., Qin B., Qu C., Retzel E.F., Riddle C., Sallet E.,
RA Samain S., Samson N., Sanders I., Saurat O., Scarpelli C., Schiex T.,
RA Segurens B., Severin A.J., Sherrier D.J., Shi R., Sims S., Singer S.R.,
RA Sinharoy S., Sterck L., Viollet A., Wang B.B., Wang K., Wang M., Wang X.,
RA Warfsmann J., Weissenbach J., White D.D., White J.D., Wiley G.B.,
RA Wincker P., Xing Y., Yang L., Yao Z., Ying F., Zhai J., Zhou L., Zuber A.,
RA Denarie J., Dixon R.A., May G.D., Schwartz D.C., Rogers J., Quetier F.,
RA Town C.D., Roe B.A.;
RT "The Medicago genome provides insight into the evolution of rhizobial
RT symbioses.";
RL Nature 480:520-524(2011).
RN [2] {ECO:0000313|EMBL:KEH40765.1, ECO:0000313|Proteomes:UP000002051}
RP GENOME REANNOTATION.
RC STRAIN=A17 {ECO:0000313|EMBL:KEH40765.1}, and cv. Jemalong A17
RC {ECO:0000313|EnsemblPlants:KEH40765,
RC ECO:0000313|Proteomes:UP000002051};
RX PubMed=24767513; DOI=10.1186/1471-2164-15-312;
RA Tang H., Krishnakumar V., Bidwell S., Rosen B., Chan A., Zhou S.,
RA Gentzbittel L., Childs K.L., Yandell M., Gundlach H., Mayer K.F.,
RA Schwartz D.C., Town C.D.;
RT "An improved genome release (version Mt4.0) for the model legume Medicago
RT truncatula.";
RL BMC Genomics 15:312-312(2014).
RN [3] {ECO:0000313|EnsemblPlants:KEH40765}
RP IDENTIFICATION.
RC STRAIN=cv. Jemalong A17 {ECO:0000313|EnsemblPlants:KEH40765};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the G-alpha family.
CC {ECO:0000256|ARBA:ARBA00005804}.
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DR EMBL; CM001217; KEH40765.1; -; Genomic_DNA.
DR RefSeq; XP_013466723.1; XM_013611269.1.
DR AlphaFoldDB; A0A072VRL1; -.
DR EnsemblPlants; KEH40765; KEH40765; MTR_1g034300.
DR GeneID; 25482678; -.
DR Gramene; KEH40765; KEH40765; MTR_1g034300.
DR KEGG; mtr:25482678; -.
DR HOGENOM; CLU_006703_0_1_1; -.
DR OrthoDB; 1221906at2759; -.
DR Proteomes; UP000002051; Chromosome 1.
DR ExpressionAtlas; A0A072VRL1; differential.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR36486; OS01G0977800 PROTEIN; 1.
DR PANTHER; PTHR36486:SF4; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002051};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT REGION 120..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 98102 MW; 3BA80BEFAF072716 CRC64;
MVSFLRKLRT SSVPSMETED SFSSNYEYSF AVVYNGPPLD HSIPEIPTFM IDQIPVASIA
PSLSHDFNVP VIQPLGKLHH KVKHKHKKTT SDSTVYPNLE SHHVVETVTS KVDVNENENV
VDDVPTNSDT IESGSGSRSG FSSPSCEICS VSEDEEVVVR AKHVKNPSAV TFRDPESNDM
IQTESDEYFD SESVQLKPHA IRPGKKGSCY KCLKGNGLTE KEVCIVCRAK YCRNCVIRAM
GSMPEGRKCV GCIGYGIDEN KRRNLGKCSR MMKQLLSETI VDQVMKDERF CEANQIPPRL
VQVNLNPLNR EELMVLLNCK NPPKELKPGS YWYDKASGFW GKEGQAPCDI ISPQLNVGGR
LQRNASNGNT NITINDREIT KNERRILKLA GVPCEGTPNF WVNPDGSYRE EGQKKDRGCI
WGKAPAKVAC AILSLPVPSK SVTLNSEGES AKKPSLHHKS LQKFLLVGCV NSGACTIFKQ
AKLLYNAPFS ENELQNIKFV IQSNLFTYLG ILLEGREDFE EECLLENRKR LPSDESSSSG
NSSENVDTTP YSIGPRLKGF SDWLLKCILS GNMDAIFPAA MREYGPMVED LWRDEAIQAT
YNRRNELKML PRSANYFLDR AIEISKIDYE PSDMDILYAE GISLSNSLTS MEFSFPKSSR
EESLYPEYQH DSSLRYQLIR VHPNILGENC KWLPMFEDTD VILFSVSLTD YDEYIIDSKG
VSTNKMLAAK NLFETIIAHP DFKKKKFVLI LTKFDLLEEK IEHVPLTRCD WFCEFNPVRS
NNNKKCGNNG TMPSLAQSAF QYIAIKFKRL FHSYTERTLF VSLVTGLEPD TIDEALRYGR
EVIEWEKWDP SIVNDKSEMT STTNGDASTS
//
