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Database: UniProt
Entry: A0A073CE82_PLAAG
LinkDB: A0A073CE82_PLAAG
Original site: A0A073CE82_PLAAG 
ID   A0A073CE82_PLAAG        Unreviewed;       359 AA.
AC   A0A073CE82;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   10-APR-2019, entry version 21.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU000579};
DE            Short=HDH {ECO:0000256|PIRNR:PIRNR036497};
DE            EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU000579};
GN   Name=thrA {ECO:0000313|EMBL:KEI66619.1};
GN   ORFNames=A19Y_1604 {ECO:0000313|EMBL:KEI66619.1};
OS   Planktothrix agardhii NIVA-CYA 126/8.
OC   Bacteria; Cyanobacteria; Oscillatoriophycideae; Oscillatoriales;
OC   Microcoleaceae; Planktothrix.
OX   NCBI_TaxID=388467 {ECO:0000313|EMBL:KEI66619.1, ECO:0000313|Proteomes:UP000027395};
RN   [1] {ECO:0000313|EMBL:KEI66619.1, ECO:0000313|Proteomes:UP000027395}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIVA-CYA 126/8 {ECO:0000313|EMBL:KEI66619.1,
RC   ECO:0000313|Proteomes:UP000027395};
RX   PubMed=24907328; DOI=10.1128/AEM.01188-14;
RA   Christiansen G., Goesmann A., Kurmayer R.;
RT   "Elucidation of insertion elements encoded on plasmids and in vitro
RT   construction of shuttle vectors from the toxic cyanobacterium
RT   Planktothrix.";
RL   Appl. Environ. Microbiol. 80:4887-4897(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036497,
CC         ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; CM002803; KEI66619.1; -; Genomic_DNA.
DR   STRING; 388467.A19Y_1604; -.
DR   EnsemblBacteria; KEI66619; KEI66619; A19Y_1604.
DR   PATRIC; fig|388467.6.peg.1538; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000027395; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027395};
KW   Isoleucine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|PIRSR:PIRSR036497-2,
KW   ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579, ECO:0000313|EMBL:KEI66619.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027395};
KW   Threonine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      283    357       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   ACT_SITE    123    123       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      23     23       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     108    108       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   359 AA;  38675 MW;  27FB64079533350F CRC64;
     MEPARSLILQ AIENGKHIVT ANKAVISRYG SEIFDAANKK GVYVMLEAAV GGGIPVIQPL
     KQSLGANRIQ TVTGIINGTT NYILTRMKNE GADFSEVLAD AQRLGYAEAD PTADIDGLDA
     GDKIAILASL AFGGRIKLEQ VYCEGIRKVT ATDITYAEKL GFVIKLLAIA SRSPQATPDQ
     DLLSVRVHPT LVTLSHPLAS INDVYNAILV EGEPIGQVMF FGRGAGSGPT ASAVVSDILN
     IVAVLQMQEA EVVNPIIPHE MMNCTHQHYC KIAPMEDLVT RFYTRFLTKD SPGVIGKLGT
     CFGQHHVSIE SIVQTGFHEN LAEIVVVTHD VLEGNFNQAL SEIKGFDEID SIPSILRVL
//
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