ID A0A073IQ87_9BACT Unreviewed; 237 AA.
AC A0A073IQ87;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=thiamine diphosphokinase {ECO:0000256|ARBA:ARBA00013245};
DE EC=2.7.6.2 {ECO:0000256|ARBA:ARBA00013245};
GN ORFNames=EH55_05945 {ECO:0000313|EMBL:KEJ91924.1};
OS Synergistes jonesii.
OC Bacteria; Synergistota; Synergistia; Synergistales; Synergistaceae;
OC Synergistes.
OX NCBI_TaxID=2754 {ECO:0000313|EMBL:KEJ91924.1, ECO:0000313|Proteomes:UP000027665};
RN [1] {ECO:0000313|EMBL:KEJ91924.1, ECO:0000313|Proteomes:UP000027665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=78-1 {ECO:0000313|EMBL:KEJ91924.1,
RC ECO:0000313|Proteomes:UP000027665};
RA Coil D.A., Eisen J.A., Holland-Moritz H.E.;
RT "Draft Genome Sequence of Synergistes jonesii.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEJ91924.1}.
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DR EMBL; JMKI01000036; KEJ91924.1; -; Genomic_DNA.
DR RefSeq; WP_051682759.1; NZ_JQEL01000036.1.
DR AlphaFoldDB; A0A073IQ87; -.
DR STRING; 2754.EH55_05945; -.
DR eggNOG; COG1564; Bacteria.
DR OrthoDB; 1678571at2; -.
DR Proteomes; UP000027665; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0030975; F:thiamine binding; IEA:InterPro.
DR GO; GO:0004788; F:thiamine diphosphokinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0006772; P:thiamine metabolic process; IEA:InterPro.
DR CDD; cd07995; TPK; 1.
DR Gene3D; 3.40.50.10240; Thiamin pyrophosphokinase, catalytic domain; 1.
DR InterPro; IPR006282; Thi_PPkinase.
DR InterPro; IPR007373; Thiamin_PyroPKinase_B1-bd.
DR InterPro; IPR007371; TPK_catalytic.
DR InterPro; IPR036759; TPK_catalytic_sf.
DR NCBIfam; TIGR01378; thi_PPkinase; 1.
DR PANTHER; PTHR41299; THIAMINE PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR41299:SF1; THIAMINE PYROPHOSPHOKINASE; 1.
DR Pfam; PF04265; TPK_B1_binding; 1.
DR Pfam; PF04263; TPK_catalytic; 1.
DR SUPFAM; SSF63999; Thiamin pyrophosphokinase, catalytic domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000027665};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 45..139
FT /note="Thiamin pyrophosphokinase catalytic"
FT /evidence="ECO:0000259|Pfam:PF04263"
FT DOMAIN 174..227
FT /note="Thiamin pyrophosphokinase thiamin-binding"
FT /evidence="ECO:0000259|Pfam:PF04265"
SQ SEQUENCE 237 AA; 26070 MW; EDC0C47A8F61A605 CRC64;
MQKTGIPHVA IECEGEKAQR SALFVLGGRE PDAAWFAAAA KGREVWAADR GVEICRKAGV
IPDMLIGDCD SAARESWEWA GALGVPCEKF PSDKELTDFQ LAVKIFCERN KNAAKKIFLT
GAWGGRFDHL WSVVISFLNF PAPHVPFCVA DEREGLALLA GAEEMKFTFD GKPKALSLIS
FSERCEGVSI RGARWPLESV ELCYAFPYAL SNRLVDGVDA LVSCGSGRLG FYWLWDE
//
