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Database: UniProt
Entry: A0A074JZ01_9RHOB
LinkDB: A0A074JZ01_9RHOB
Original site: A0A074JZ01_9RHOB 
ID   A0A074JZ01_9RHOB        Unreviewed;       691 AA.
AC   A0A074JZ01;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   08-MAY-2019, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KEO61704.1};
GN   ORFNames=DT23_01660 {ECO:0000313|EMBL:KEO61704.1};
OS   Thioclava indica.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Thioclava.
OX   NCBI_TaxID=1353528 {ECO:0000313|EMBL:KEO61704.1, ECO:0000313|Proteomes:UP000027471};
RN   [1] {ECO:0000313|EMBL:KEO61704.1, ECO:0000313|Proteomes:UP000027471}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DT23-4 {ECO:0000313|EMBL:KEO61704.1,
RC   ECO:0000313|Proteomes:UP000027471};
RX   PubMed=25361528; DOI=10.1007/s10482-014-0320-3;
RA   Liu Y., Lai Q., Du J., Xu H., Jiang L., Shao Z.;
RT   "Thioclava indica sp. nov., isolated from surface seawater of the
RT   Indian Ocean.";
RL   Antonie Van Leeuwenhoek 107:297-304(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+)
CC         + NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57318, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|SAAS:SAAS01123908};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|SAAS:SAAS00324886}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KEO61704.1}.
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DR   EMBL; AUNB01000001; KEO61704.1; -; Genomic_DNA.
DR   RefSeq; WP_038127452.1; NZ_AUNB01000001.1.
DR   STRING; 1353528.DT23_01660; -.
DR   EnsemblBacteria; KEO61704; KEO61704; DT23_01660.
DR   OrthoDB; 977512at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000027471; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; SSF48179; 2.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00067; 3HCDH; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000027471};
KW   Fatty acid metabolism {ECO:0000256|SAAS:SAAS00324839};
KW   Lipid metabolism {ECO:0000256|SAAS:SAAS00324863};
KW   NAD {ECO:0000256|SAAS:SAAS00830857};
KW   Oxidoreductase {ECO:0000256|SAAS:SAAS00324627};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027471}.
FT   DOMAIN      321    495       3HCDH_N. {ECO:0000259|Pfam:PF02737}.
FT   DOMAIN      498    592       3HCDH. {ECO:0000259|Pfam:PF00725}.
SQ   SEQUENCE   691 AA;  74093 MW;  10A8334F5D66EA52 CRC64;
     MTGHVLEFLG ETKLELGPVA DADGNWRTGR DDAGVLWLVL DKQNTGMNTI SQDVIRELDQ
     LITAAEADLP KALVIRSAKS AGFAAGADIS GFAEMSDEGA VELLHQAHSV LDRIEALNCP
     TVCVIHGAAL GAGFEIALAC DYRIATPGAS FGFPEVQLGL HPGLGGTFRL PALIGASDAM
     TMMLTGKTAH TQRAKSQGIV DVVVEERHVA ATIDAIASGE IDKHEPGLTS RAFGFDQARS
     LAARQMRSQT EKKAPKQHYP APYALIDLWE NHGDDRKAMQ QGEVESFAEL LKTETSKNLR
     RVFFLRQTLK EAGRGDDGIS HVHVIGAGAM GAEIAAMAAI KGKSVTLSDI ETEPLGRAIK
     KAGEICKDKH LSATETRDAL DRLMPDPHSY GLAHADLVIE AATERQDLKE EIYEGLRGKI
     KTGAILASNT SSLSIADLTA FAPSKTHFAG LHFFNPVSRI DLIEVVKAEA TSDQTAQRLA
     AFCGAIGKLP ARVKDYPGFV VNRALVPYML EAMVLMNEGV SKDVIDTAAL RFGMPMGPVT
     LADQVGLDVG LQVAESLSKS LRTPMPPISD DLRRKVEASD LGKKTGTGFY DWSDGPPHPD
     ADLDDAPDDL TDRLILPMLN ACVEVLREGV AQDADQIDAA MIFATGWAPF RGGPMHYAKQ
     RGVNEITAKL HALQKAHGPR FAPDEGWSSL A
//
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