ID A0A074K1V5_9RHOB Unreviewed; 908 AA.
AC A0A074K1V5;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Serine protease {ECO:0000256|RuleBase:RU004296};
DE EC=3.4.21.- {ECO:0000256|RuleBase:RU004296};
GN ORFNames=DT23_06205 {ECO:0000313|EMBL:KEO55562.1};
OS Thioclava indica.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Thioclava.
OX NCBI_TaxID=1353528 {ECO:0000313|EMBL:KEO55562.1, ECO:0000313|Proteomes:UP000027471};
RN [1] {ECO:0000313|EMBL:KEO55562.1, ECO:0000313|Proteomes:UP000027471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DT23-4 {ECO:0000313|EMBL:KEO55562.1,
RC ECO:0000313|Proteomes:UP000027471};
RX PubMed=25361528; DOI=10.1007/s10482-014-0320-3;
RA Liu Y., Lai Q., Du J., Xu H., Jiang L., Shao Z.;
RT "Thioclava indica sp. nov., isolated from surface seawater of the Indian
RT Ocean.";
RL Antonie Van Leeuwenhoek 107:297-304(2015).
CC -!- SIMILARITY: Belongs to the peptidase S1B family.
CC {ECO:0000256|ARBA:ARBA00008764, ECO:0000256|RuleBase:RU004296}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KEO55562.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AUNB01000051; KEO55562.1; -; Genomic_DNA.
DR RefSeq; WP_051697315.1; NZ_AUNB01000051.1.
DR AlphaFoldDB; A0A074K1V5; -.
DR eggNOG; COG2374; Bacteria.
DR eggNOG; COG3591; Bacteria.
DR eggNOG; COG4249; Bacteria.
DR OrthoDB; 500593at2; -.
DR Proteomes; UP000027471; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR008256; Peptidase_S1B.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR36234; LYSYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR36234:SF5; LYSYL ENDOPEPTIDASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00839; V8PROTEASE.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU004296};
KW Protease {ECO:0000256|RuleBase:RU004296};
KW Reference proteome {ECO:0000313|Proteomes:UP000027471};
KW Serine protease {ECO:0000256|RuleBase:RU004296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 93..291
FT /note="SGNH hydrolase-type esterase"
FT /evidence="ECO:0000259|Pfam:PF13472"
FT DOMAIN 634..886
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT ACT_SITE 422
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR608256-1"
FT ACT_SITE 463
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR608256-1"
FT ACT_SITE 534
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR608256-1"
SQ SEQUENCE 908 AA; 99828 MW; 44D100CC797C6D32 CRC64;
MTTQITLTEL KAKIRDIDTP DEEIAAYLLA APEASDAFAP QVRINPDLVD DEGTEADVAM
RFFNAMSKRR RQKKYLRKIE NGWTGLRVVS EGDSWFQYPF LLHDVIDQLF DDYAIYSLGA
AGDLVQDMLD QDEILQAVRQ HNPHVFLISG GGNDLLGDGM LQTALHPFKT GKLAKDYPNS
TFTKRLKDII GVYRSIFTTL LAEFPNLKIL CHGYDYAQPA NARWLGKPME ALGIKDKTLQ
AQIVAELVER FNTALVDLAA EFPGSVVRVS CLNCVGSNWH DELHPNNTGY GAAAGKFRAI
IDSMFGANAP FEVTAPLSPG KEAKIDAHDL NPEAFRELVD HRGRELLDTP LPPTEDEARR
KEIEQDISQH FEKISGGADF LPASFLYRGA DAAAAVCRIN LPGGSGTGFM IATRNFIMTN
NHVIGDEDEA REAVAEFNFE EGGASLMVNL DPDRFFVTST ELDFTIVGCD DPALEIFDPI
PLLRNPSTVT RGEKVNIVQH PRGRPKEVAL HNNDVLRVKD KVIWYETDTE PGSSGSPVFN
NTWDLVALHH AGWVEGGVTT NEGVRIAAIV SHLVARQHIE ATASFKLMEL LSTVPDSSPH
LGFFDIAGIT GSSVQEVEVP EYKGSLEFAD IGFWNIEHFN DAISDTRVDK VACVLGHLSL
DAMGLVEVQK DAMERLIASL QALGHSYDYK YLDVKGRQDL AVLYDSKTTE VNISAKILNR
HKTAWAATTE SGRTAFPRRP LIATVKVAPN TEGGDPVEFI MILLHLKAFG DPQSKARRRL
AAEILTEVIA DIRKTEKLPV VLGGDLNETL NTDVLGPLTD APDLFTLTTD DAADNALSYV
GARYRSLIDH IVVSNDVHMA PISGDDAAIV RLDKSVADFT RDVSDHVPLV IRMVSRDAPI
QIGSAGKK
//
