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Database: UniProt
Entry: A0A074T3U8_HAMHA
LinkDB: A0A074T3U8_HAMHA
Original site: A0A074T3U8_HAMHA 
ID   A0A074T3U8_HAMHA        Unreviewed;      1261 AA.
AC   A0A074T3U8;
DT   01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2014, sequence version 1.
DT   03-JUL-2019, entry version 29.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=HHA_258030 {ECO:0000313|EMBL:KEP66486.1};
OS   Hammondia hammondi (Parasitic protozoan).
OC   Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Hammondia.
OX   NCBI_TaxID=99158 {ECO:0000313|EMBL:KEP66486.1, ECO:0000313|Proteomes:UP000027470};
RN   [1] {ECO:0000313|EMBL:KEP66486.1, ECO:0000313|Proteomes:UP000027470}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H.H.34 {ECO:0000313|EMBL:KEP66486.1,
RC   ECO:0000313|Proteomes:UP000027470};
RA   Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A.,
RA   Brunk B., Roos D., Caler E., Lorenzi H.;
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; KL544029; KEP66486.1; -; Genomic_DNA.
DR   RefSeq; XP_008883194.1; XM_008884972.1.
DR   STRING; 99158.XP_008883194.1; -.
DR   EnsemblProtists; KEP66486; KEP66486; HHA_258030.
DR   OMA; CLVNYTE; -.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000027470; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000027470};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442,
KW   ECO:0000313|EMBL:KEP66486.1};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000027470};
KW   Transferase {ECO:0000256|RuleBase:RU000442,
KW   ECO:0000313|EMBL:KEP66486.1}; Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      181    635       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      701   1131       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN     1169   1238       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     49       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A074T3U8}.
FT   REGION      302    337       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A074T3U8}.
FT   COILED      823    843       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS     11     43       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A074T3U8}.
SQ   SEQUENCE   1261 AA;  139316 MW;  6CC7F1722209E096 CRC64;
     MAGNGTPKKG SPLPGATQNR QGSSEGQAST SSPASQRSPA PRSLPTASAP IDVLGFCGAS
     EEREKQETQW SDLLQLWSRE GPAEERELTL QHPHDSKKDL VFFQLDIANA TCHRNVVPAA
     IRARHRALPV SSAPPATVCA SYEPEVSPTP APAAVPPGAQ AAEAAATANS LGPMFRVYGV
     TEDGRSVCAN VHGFFPYFYC HVPASIQESL GKQPGGGVGT NAVTARLRSF LDAWLLKTQA
     SAKAYDVRCL DVRMEKKESL MYYTPGQTPS LFFRITLALP NWVAPTRTLI ERGISIEASL
     AATPSSDTGG ANCTAAQNEA PAEEAADWPD ADGDAAAGEE TACDAQMLAV ANALSDAGSG
     AKVALPPATF ESNVPFVLRY LVDTKTTGCS WLLGRGGSYV VRPASLQETS AQLELDIHYA
     DLLPLPPAER WQKLPPLRIL SFDIECVKMK GEGFPEAETD PVIQISSIVM LQSPPADLPG
     LAETDANAAT ACVAKARKKR LSGGLERPLC RVLFALKECA SIAGSVVLWF DDEKEMLAKW
     AEFVRQVDPD FISGYNCVNF DLNYLITRAA TLKIEGFNRL SKLKSLESKI RDSSFSSRAL
     GTHEGKDIPT EGRIQFDLLE LVRRDYKLKS YSLNFVSFEF LKEQKEDVHY NMIGDLFRGC
     PSSRRRIGVY CLKDAYLPLR LLKELLFLYN YVEMSRVTGT PLNFLLTRGQ QIKVTAQLLR
     KCKELNYLVP VVKRTGGDNS VQYEGATVLE PRKGFYDKPI ATLDFASLYP SIMIAHNICY
     STLVAASAAH KMNNPDDVTV TTTSPPHKFV KKHIRRGVLP MIVEELIAAR KAARKEMAAA
     KDEMTRQVLN GRQLALKISA NSVYGYTGTT TGGQLPCLEV ATTITCFGRD MIEFTRREVE
     KMFCRDNNHA CNATVIYGDT DSVMVDFGDF SIAEAMKLGE EAAQALSEKF VKPIRLEFEK
     VYCPFLLMNK KRYAGLLYTR PEKYDKIDSK GIETVRRDFS LLVQTMADTV LRKMLIDKDV
     EAAKEYTRRK VAELLQNKVD LSLLVQTKSL GKMDYDTRLP HVELAKKLRK RDAGTAPSVG
     DRVSYVVIQG SKGQAQYERA EDPLYVLENN LPIDTQHYLE GIKKPLCRIF EGVMSNPESL
     FSGTHTMKRT VSISTQGALS KFVQRGVQCV GCRSVIREGT LCRRCQENEP EIVVNKVAEM
     AEKEKEHSDL WTECQRCQGS LHQDVICINR DCPIFYRRAK VKKDIGTLEE RLSSLSLSSD
     W
//
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