ID A0A074VHD9_9PEZI Unreviewed; 434 AA.
AC A0A074VHD9;
DT 01-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2014, sequence version 1.
DT 28-JUN-2023, entry version 25.
DE SubName: Full=SET domain-containing protein {ECO:0000313|EMBL:KEQ58479.1};
DE Flags: Fragment;
GN ORFNames=M437DRAFT_59348 {ECO:0000313|EMBL:KEQ58479.1};
OS Aureobasidium melanogenum CBS 110374.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Dothideales; Saccotheciaceae; Aureobasidium.
OX NCBI_TaxID=1043003 {ECO:0000313|EMBL:KEQ58479.1, ECO:0000313|Proteomes:UP000030672};
RN [1] {ECO:0000313|EMBL:KEQ58479.1, ECO:0000313|Proteomes:UP000030672}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 110374 {ECO:0000313|EMBL:KEQ58479.1,
RC ECO:0000313|Proteomes:UP000030672};
RX PubMed=24984952;
RA Gostin Ar C., Ohm R.A., Kogej T., Sonjak S., Turk M., Zajc J., Zalar P.,
RA Grube M., Sun H., Han J., Sharma A., Chiniquy J., Ngan C.Y., Lipzen A.,
RA Barry K., Grigoriev I.V., Gunde-Cimerman N.;
RT "Genome sequencing of four Aureobasidium pullulans varieties:
RT biotechnological potential, stress tolerance, and description of new
RT species.";
RL BMC Genomics 15:549-549(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KL584855; KEQ58479.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A074VHD9; -.
DR STRING; 1043003.A0A074VHD9; -.
DR HOGENOM; CLU_632479_0_0_1; -.
DR OrthoDB; 902834at2759; -.
DR Proteomes; UP000030672; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000030672};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 188..301
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 316..434
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 170..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 434
FT /evidence="ECO:0000313|EMBL:KEQ58479.1"
SQ SEQUENCE 434 AA; 49620 MW; 72FAAB69731D4066 CRC64;
MDTILKYLLE ASEGPDGLLS RLTDFAYDVK FARTIIRAKD KYCKDDFDRT SQRWVSVASS
LPEIDDETLW KAAVVCHTFW IRTNFSPWQI ARKYATFPDH NKIEGLVTYE AAKNYASVAC
SICQLHDCPF HGTILERPDA KDLSDEEDDA NSVDALDVDY PPRVNYKELA TAPLEREPPG
GTSPAQPKKP LNWWMNEANS VTWDHSQRGP FFPCNHPGSS CEDARCSCFE ARVCCEKTCG
CSKNCSRRFQ GCSCARRTRC CAQDDSCECF RMNRECDPDL CDSCEAHVIL DPVNRFDDEY
LDRRCRNVAI QRGVPKRTLL GRSLVHGFGL YAGEPIAKGE FVGEYQGEII TRDETERRGA
IYDFQKLSYI FDLNRDQTID SQRMGNKIRF INHAANSHLR NIRPKIMLCN LAHRIGMFAH
RDIKVGEELF FDYG
//
